Cellular senescence and ophthalmic diseases: narrative review

Soleimani, Mohammad Ali; Cheraqpour, Kasra; Koganti, Raghuram; Djalilian, Ali R.

doi:10.1007/s00417-023-06070-9

Cited by 8 publications

(2 citation statements)

References 129 publications

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“…Graft-versus-host disease (GVHD), fuchs endothelial dystrophy (FED), dry eye disease, and conjunctivochalasis are among the ocular conditions that senescence has been accused of in their physiopathology. The overall literature on senescence and ocular disease is growing rapidly, bringing attention toward developing anti-senescence treatment [20].…”

Section: Discussionmentioning

confidence: 99%

“…Due to their anti-inflammatory, immunomodulatory, and substantial antioxidant properties, MSCs have become a widely used therapeutic option, protecting cells from apoptosis, vascular and oxidative DNA damage, and cell death [15][16][17]. Particularly in ocular tissues, these cells exhibit anti-inflammatory and anti-fibrotic effects, serving as a viable option for corneal wound healing [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

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The Potential of Mesenchymal Stem/Stromal Cell Therapy in Mustard Keratopathy: Discovering New Roads to Combat Cellular Senescence

Soleimani,

Mirzaei,

Cheraqpour

et al. 2023

Cells

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Mesenchymal stem/stromal cells (MSCs) are considered a valuable option to treat ocular surface disorders such as mustard keratopathy (MK). MK often leads to vision impairment due to corneal opacification and neovascularization and cellular senescence seems to have a role in its pathophysiology. Herein, we utilized intrastromal MSC injections to treat MK. Thirty-two mice were divided into four groups based on the exposure to 20 mM or 40 mM concentrations of mustard and receiving the treatment or not. Mice were clinically and histopathologically examined. Histopathological evaluations were completed after the euthanasia of mice after four months and included hematoxylin and eosin (H&E), CK12, and beta-galactosidase (β-gal) staining. The treatment group demonstrated reduced opacity compared to the control group. While corneal neovascularization did not display significant variations between the groups, the control group did register higher numerical values. Histopathologically, reduced CK12 staining was detected in the control group. Additionally, β-gal staining areas were notably lower in the treatment group. Although the treated groups showed lower severity of fibrosis compared to the control groups, statistical difference was not significant. In conclusion, it seems that delivery of MSCs in MK has exhibited promising therapeutic results, notably in reducing corneal opacity. Furthermore, the significant reduction in the β-galactosidase staining area may point towards the promising anti-senescence potential of MSCs.

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Section: Discussionmentioning

confidence: 99%