2021
DOI: 10.1021/acs.jpcb.1c07894
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Cellular Signaling beyond the Wiener–Kolmogorov Limit

Abstract: Accurate propagation of signals through stochastic biochemical networks involves significant expenditure of cellular resources. The same is true for regulatory mechanisms that suppress fluctuations in biomolecular populations. Wiener–Kolmogorov (WK) optimal noise filter theory, originally developed for engineering problems, has recently emerged as a valuable tool to estimate the maximum performance achievable in such biological systems for a given metabolic cost. However, WK theory has one assumption that pote… Show more

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