Cellular signaling pathways modulated by low-intensity extracorporeal shock wave therapy

Liu, Tianshu; Shindel, A.W.; Lin, Guiting; Lue, Tom F.

doi:10.1038/s41443-019-0113-3

Cited by 80 publications

(69 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…LIESWT has been shown to induce the release of vascular endothelial growth factor (VEGF) and nitric oxide, key mediators in angiogenesis and collateral blood vessel formation [ 9 10 11 ]. It is postulated that LIESWT causes repetitive shear stress (microtrauma) to target tissue resulting in a cascade of biological reactions including the release of various angiogenic factors, such as endothelial nitric oxide synthase [ 12 ] and VEGF [ 13 ].…”

Section: Proposed Mechanisms Of Action On Erectile Functionmentioning

confidence: 99%

Clinical Practice Guideline Recommendation on the Use of Low Intensity Extracorporeal Shock Wave Therapy and Low Intensity Pulsed Ultrasound Shock Wave Therapy to Treat Erectile Dysfunction: The Asia-Pacific Society for Sexual Medicine Position Statement

Chung

Lee

Liu

et al. 2021

World J Mens Health

View full text Add to dashboard Cite

Published literature shows low intensity extracorporeal shock wave therapy (LIESWT) and low intensity pulsed ultrasound (LI-PUS) therapy to improve erectile function and penile hemodynamic by inducing neovascularisation and promoting tissue regeneration. Key opinion leaders across the Asia Pacific region attended the recent biennial meeting of the Asia Pacific Society for Sexual Medicine in Australia, and presented the current evidence on LIESWT and LIPUS for erectile dysfunction (ED). The clinical findings were internally discussed, and the quality of evidence was graded based on the Oxford Centre for Evidence-Based Medicine recommendations. Existing literature supports the use of LIESWT and LIPUS in men with ED, with many clinical studies reported encouraging results with improved erectile function, good safety profile and short-term durability. However, controversial exists due to sampling heterogeneity, non-standardised treatment protocol and lack of large multiinstitutional studies. There is a need to better define which subgroup of ED population is best-suited, and specific treatment protocol to optimise shock wave energy delivery. More stringent and larger multi-institutional randomised placebo-controlled trials are warranted before clinical adoption of LIESWT and LIPUS as the new standard of care for men with ED.

show abstract

Section: Proposed Mechanisms Of Action On Erectile Functionmentioning

confidence: 99%

Clinical Practice Guideline Recommendation on the Use of Low Intensity Extracorporeal Shock Wave Therapy and Low Intensity Pulsed Ultrasound Shock Wave Therapy to Treat Erectile Dysfunction: The Asia-Pacific Society for Sexual Medicine Position Statement

Chung

Lee

Liu

et al. 2021

World J Mens Health

View full text Add to dashboard Cite

show abstract

“…Therefore further investigation to hold SA-hydrogel on GCE is required, including layer-by-layer method (Mizutani et al, 1998) and combination with chitosan-or silk-film (Chen et al, 2011;Liu et al, 2012).…”

Section: Biocatalytic Glucose Oxidation Using a Hydrogel-coated Electmentioning

confidence: 99%

Streptavidin-hydrogel prepared by sortase A-assisted click chemistry for enzyme immobilization on an electrode

Matsumoto

Isogawa

Tanaka

et al. 2018

Biosensors and Bioelectronics

View full text Add to dashboard Cite

A tetrameric streptavidin (SA)-appended LPETG tag was site-specifically linked to azido-containing tri-glycine via sortase A catalysis and the resulting azido-modified SA (SA-N3) was retained in the biotin-binding pocket. SA-N3 was polymerized with dibenzylcyclooctyne-modified branched poly(ethyleneglycol) (DBCO-PEG) using azido-modified branched PEG (N3-PEG) as a spacer via copper-free click chemistry. The resulting SA-based hydrogel exhibited gel-like mechanical properties and could immobilize biotin-modified molecules through biotin-SA affinity. Glucose dehydrogenase (GDH) was immobilized in the SA-based hydrogel, and the hydrogel was then coated on a glassy carbon electrode (GCE) and used for the biocatalytic oxidation of glucose. The designed GCE exhibited better performance and stability compared with GDH chemically adsorbed onto a GCE. In addition, the designed GCE anode and a Pt-carbon cathode were assembled into a glucose/O fuel cell that provided a maximum power density and open circuit voltage of 11.8±0.56µWcm and 0.17V, respectively.

show abstract

“…The possible effect of low-intensity shock wave treatment has been recently presented [32]. Therefore, this offers a possible additional benefit if stem cell treatment is combined with shock wave sessions but more studies are needed in the field.…”

Section: Discussionmentioning

confidence: 99%

The Combined Use of Stem Cells and Platelet Lysate Plasma for the Treatment of Erectile Dysfunction: A Pilot Study–6 Months Results

Protogerou

Beshari²,

Michalopoulos

et al. 2020

Medicines

View full text Add to dashboard Cite

Background: The current treatment of Erectile Dysfunction (ED) is mainly based on the use of drugs that provide erections shortly after use but they do not really treat the problem. Stem cell therapy is a novel treatment with regenerative properties that can possibly treat erectile dysfunction. Methods: Five patients with erectile disease were treated with Adipose-Derived Stem Cells (ADSCs) and Platelet Lysate Plasma (PLP). ADSCs were obtained through abdominal liposuction and PLP was prepared after obtaining blood samples from peripheral veins. Erectile function was evaluated with the International Index of Erectile Function questionnaire (IIEF-5) questionnaire, penile triplex at the 1st, 3rd, 6th and 12th month post-treatment. A CT scan of the head, thorax and abdomen was done before treatment and at the 12th month. Results: IIEF-5 scores were improved in all patients at the 6th month although not in the same pattern in all patients. Peak Systolic Velocity (PSV) also improved at the 6th month in all patients but also with different patterns in each patient, while End Diastolic Velocity (EDV) was more variable. Two patients decreased the treatment they used in order to obtain erection (from Intracavernosal injections (ICI) they used PDE-5Is), two had unassisted erections and one had an initial improvement which decreased at the 6th month. There were no side effects noted. Conclusions: Stem cell therapy in combination with PLP appears to show some improvement in erectile function and has minimal side effects in the short term.

show abstract

Cellular signaling pathways modulated by low-intensity extracorporeal shock wave therapy

Cited by 80 publications

References 53 publications

Clinical Practice Guideline Recommendation on the Use of Low Intensity Extracorporeal Shock Wave Therapy and Low Intensity Pulsed Ultrasound Shock Wave Therapy to Treat Erectile Dysfunction: The Asia-Pacific Society for Sexual Medicine Position Statement

Clinical Practice Guideline Recommendation on the Use of Low Intensity Extracorporeal Shock Wave Therapy and Low Intensity Pulsed Ultrasound Shock Wave Therapy to Treat Erectile Dysfunction: The Asia-Pacific Society for Sexual Medicine Position Statement

Streptavidin-hydrogel prepared by sortase A-assisted click chemistry for enzyme immobilization on an electrode

The Combined Use of Stem Cells and Platelet Lysate Plasma for the Treatment of Erectile Dysfunction: A Pilot Study–6 Months Results

Contact Info

Product

Resources

About