Cellular Synthesis and X‐ray Crystal Structure of a Designed Protein Heterocatenane

Liu, Huan; Duan, Zelin; Fang, Jing; Zhang, Fan; Xiao, Junyu; Zhang, Wenbing

doi:10.1002/anie.202005490

Cited by 21 publications

(42 citation statements)

References 56 publications

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“…As a result, specific conformations are accessible to perform useful tasks that would otherwise be inaccessible by their counterparts without topological constraints. During the process of exploring [190][191][192] the roles played by topological DNA and proteins, more nature-mimicking functions will be discovered.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, Zhang 190,191 has developed more programmable, autonomous and highyielding ligation tools, making it possible to access a wide variety of protein topologies.…”

Section: Discussionmentioning

confidence: 99%

“…The first synthetic DNA catenanes were described in 1967 by Wang and Schwartz, 189 who reproduced Wasserman's statistical protocol 67 An active template-directed and autonomous cellular [190][191][192] synthesis has opened up promising and versatile methods for engineering of synthetic mechanically interlocked proteins. A well-established catalytic center, employed in the synthesis of MIMs, 78,80,193 has been introduced in order to encourage the entwinement of polypeptide chains.…”

Section: Synthesis Of Natural Macromolecules Exhibiting Molecular Nanotopologymentioning

confidence: 99%

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The Rise and Promise of Molecular Nanotopology

et al. 2021

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Molecular nanotopology-a term we coined recently-is a rapidly developing field of research that is emerging out of the confluence of chemical topology with the mechanical bond. By focusing on the increased research activities in this field, it is clear that a new discipline is ready to receive recognition in its own right. In this Mini-Review, we address the historical development of chemical topology and describe how the rational design and practical synthesis of molecular links and knots with mechanical bonds, together with interwoven extended frameworks, have led to the rapid establishment of molecular nanotopology as a discipline. Representative examples are highlighted in order to offer the reader an extensive overview of ongoing research. We spotlight the major challenges facing chemists and materials scientists and provide some pointers as to how molecular nanotopology is going to develop in the years ahead.

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Section: Discussionmentioning

confidence: 99%

“…Recently, Zhang 190,191 has developed more programmable, autonomous and highyielding ligation tools, making it possible to access a wide variety of protein topologies.…”

Section: Discussionmentioning

confidence: 99%

Section: Synthesis Of Natural Macromolecules Exhibiting Molecular Nanotopologymentioning

confidence: 99%

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The Rise and Promise of Molecular Nanotopology

et al. 2021

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“…A series of topological proteins have been synthesized in cellulo. Examples include the passive template synthesis of protein [n]catenanes [25][26][27] and lasso proteins [28] and the active template synthesis of protein heterocatenanes [29] (Figure 2a). Functional improvements have been identified for these unconventional topologies, including enhanced stability against proteolytic degradation and thermal/chemical/mechanical denaturation (Figure 2b) [30,31].…”

Section: Genetically Engineered Protein Building Blocksmentioning

confidence: 99%

Genetically engineered materials: Proteins and beyond

Wei

et al. 2022

Sci. China Chem.

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Information-rich molecules provide opportunities for evolution. Genetically engineered materials are superior in that their properties are coded within genetic sequences and could be fine-tuned. In this review, we elaborate the concept of genetically engineered materials (GEMs) using examples ranging from engineered protein materials to engineered living materials. Protein-based materials are the materials of choice by nature. Recent progress in protein engineering has led to opportunities to tune their sequences for optimal material performance. Proteins also play a central role in living materials where they act in concert with other biological components as well as nonbiological cofactors, giving rise to living features. While the existing GEMs are often limited to those constructed by building blocks of biological origin, being genetically engineerable does not preclude nonbiologic or synthetic materials, the latter of which have yet to be fully explored.

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“…Therefore, amino functionalization of catalyst surface is expected to enhance the activity of CO 2 electrocatalytic reduction. Meanwhile, the hollow structure can effectively increase electrochemically active area of the catalyst, provide abundant active sites, and improve the mass transfer and charge transfer efficiency . Inspired by these results, we modified hollow nanorods composed of SnS (stannous sulfide) nanosheets with amino‐functionalized carbon (denoted as SnS/Aminated‐C) for enhancing the current density and formate productivity of Sn‐based catalysts for electrocatalytic reduction of CO 2 .…”

Section: Introductionmentioning

confidence: 99%

Engineering Electronic Structure of Stannous Sulfide by Amino‐Functionalized Carbon: Toward Efficient Electrocatalytic Reduction of CO₂ to Formate

Chen

Zhang

Jiao

et al. 2020

Advanced Energy Materials

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Engineering electronic structure to enhance the binding energies of reaction intermediates in order to achieve a high partial current density can lead to increased yield of target products. Herein, amino‐functionalized carbon is used to regulate the electronic structure of tin‐based catalysts to enhance activity of CO2 electroreduction. The hollow nanotubes composed of SnS (stannous sulfide) nanosheets are modified with amino‐functionalized carbon layers, achieving a highest formate Faraday efficiency of 92.6% and a remarkable formate partial current density of 41.1 mA cm−2 (a total current density of 52.1 mA cm−2) at a moderate overpotential of 0.9 V versus reversible hydrogen electrode, as well as a good stability. Density functional theory calculations demonstrate that the superior activity is attributed to the synergistic effect among SnS and Aminated‐C in increasing the adsorption energies of the key intermediates and accelerating the charge transfer rate.

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Cellular Synthesis and X‐ray Crystal Structure of a Designed Protein Heterocatenane

Cited by 21 publications

References 56 publications

The Rise and Promise of Molecular Nanotopology

The Rise and Promise of Molecular Nanotopology

Genetically engineered materials: Proteins and beyond

Engineering Electronic Structure of Stannous Sulfide by Amino‐Functionalized Carbon: Toward Efficient Electrocatalytic Reduction of CO₂ to Formate

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Cellular Synthesis and X‐ray Crystal Structure of a Designed Protein Heterocatenane

Cited by 21 publications

References 56 publications

The Rise and Promise of Molecular Nanotopology

The Rise and Promise of Molecular Nanotopology

Genetically engineered materials: Proteins and beyond

Engineering Electronic Structure of Stannous Sulfide by Amino‐Functionalized Carbon: Toward Efficient Electrocatalytic Reduction of CO2 to Formate

Contact Info

Product

Resources

About

Engineering Electronic Structure of Stannous Sulfide by Amino‐Functionalized Carbon: Toward Efficient Electrocatalytic Reduction of CO₂ to Formate