Cellular uptake and cytotoxicity of unmodified Pr3+:LaF3 nanoparticles

Pudovkin, M.S.; Zelenikhin, P. V.; Shtyreva, Victoria; Evtugyn, Vladimir G.; Salnikov, Vadim V.; Низамутдинов, А. С.; Семашко, В. В.

doi:10.1007/s11051-019-4628-9

Cited by 17 publications

(8 citation statements)

References 37 publications

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“…Plasma membrane extrusions have a diameter value in the 30-60 nm range. The same cell membrane structural features of A 549 cells were observed in works [25][26][27]. The cytoplasm contains vesicles having a diameter in the range from 200 to 2000 nm.…”

Section: Visualization Of Nanoparticles Internalization By A549 Cells...supporting

confidence: 64%

“…The composites and the conjugates are not observed in the cell nucleus. It seems that coated fluoride nanoparticles are uptaken more efficiently in comparison to unmodified fluoride nanoparticles [26,27]. It can be suggested that the polymer coating and Radachlorin conjugation provide a positive zeta potential of nanoparticles [29].…”

Section: Visualization Of Nanoparticles Internalization By A549 Cells...mentioning

confidence: 99%

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CeF3-YF3-TbF3 Nanoparticle-Polymer–“Radachlorin” Conjugates for Combined Photodynamic Therapy: Synthesis, Characterization, and Biological Activity

et al. 2023

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Promising material for hybrid photodynamic therapy consisting of Ce0.5Y0.35Tb0.15F3 crystalline nanoparticles and Radachlorin is reported. One possible option of conjugation of Ce0.5Y0.35Tb0.15F3 nanoparticles and Radachlorin using polyethylenimine (PEI) is tested. The energy transfer reaches 28%. It is shown that conjugates of CeF3—Tb3+ NPs and Radachlorin using PEI—are stable, and the distance between nanoparticles and photosensitizer molecules is about 5 nm.

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Section: Visualization Of Nanoparticles Internalization By A549 Cells...supporting

confidence: 64%

Section: Visualization Of Nanoparticles Internalization By A549 Cells...mentioning

confidence: 99%

CeF3-YF3-TbF3 Nanoparticle-Polymer–“Radachlorin” Conjugates for Combined Photodynamic Therapy: Synthesis, Characterization, and Biological Activity

et al. 2023

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“…By the combination of the properties of our NPs: (1) "green" water synthesis, (2) short synthesis duration, (3) long-term stability of an aqueous colloid within several months without observable sedimentation of NPs [19], (4) no additional modification of the NPs surface, (5) high luminescence brightness in the first biological transparency window, and (6) low cytotoxicity [21,66], the aqueous colloidal solutions of Nd 3+ : LaF 3 NPs of type II surpass the similar aqueous colloidal solutions of Nd 3+ : LaF 3 NPs described in the literature.…”

Section: Fluorescence Decay Kinetics Relative Fluorescence Quantum Yield and Brightness Of Aqueous Colloidal Solutionsmentioning

confidence: 99%

Stable Aqueous Colloidal Solutions of Nd3+: LaF3 Nanoparticles, Promising for Luminescent Bioimaging in the Near-Infrared Spectral Range

et al. 2021

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Two series of stable aqueous colloidal solutions of Nd3+: LaF3 single-phase well-crystallized nanoparticles (NPs), possessing a fluorcerite structure with different activator concentrations in each series, were synthesized. A hydrothermal method involving microwave-assisted heating (HTMW) in two Berghof speedwave devices equipped with one magnetron (type I) or two magnetrons (type II) was used. The average sizes of NPs are 15.4 ± 6 nm (type I) and 21 ± 7 nm (type II). Both types of NPs have a size distribution that is well described by a double Gaussian function. The fluorescence kinetics of the 4F3/2 level of the Nd3+ ion for NPs of both types, in contrast to a similar bulk crystal, demonstrates a luminescence quenching associated not only with Nd–Nd self-quenching, but also with an additional Nd–OH quenching. A method has been developed for determining the spontaneous radiative lifetime of the excited state of a dopant ion, with the significant contribution of the luminescence quenching caused by the presence of the impurity OH– acceptors located in the bulk of NPs. The relative quantum yield of fluorescence and the fluorescence brightness of an aqueous colloidal solution of type II NPs with an optimal concentration of Nd3+ are only 2.5 times lower than those of analogous Nd3+: LaF3 single crystals.

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“…In turn, the temperature dependence of the luminescence signal should be known [2,3]. Among a huge variety of inorganic phosphors including oxides and quantum dots, rare-earth-doped fluoride nanoparticles pay a special role due to high chemical and mechanical stability, bright narrow luminescence peaks [4], and, in some cases low cytotoxicity [5,6]. Yttrium fluoride is considered very promising host-matrix due to low phonon energy (around 500 cm -1 ), which leads to the decrease in the non-radiative transition probability.…”

Section: Introductionmentioning

confidence: 99%

Spectral-Kinetic Characterization of YF3: Eu3+ and YF3: (Eu3+, Nd3+) Nanoparticles for Optical Temperature Sensing

Oleynikova,

Morozov,

Korableva

et al. 2024

Preprint

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The YF3: (Eu3+, Nd3+) nanoparticles (orthorhombic phase, D ~ 130 nm)) were synthesized via the co-precipitation method with subsequent hydrothermal treatment and annealing. The Eu3+ τdecay linearly descends with the increase of temperature in the 80 - 320 K range. The τdecay (T) slope values of the annealed YF3: Eu3+ (2.5 and 5.0 mol. %) nanoparticles were the highest (110·10-4 and 67·10-4, μs/K in the whole 80 – 320 K range, respectively. Thus, these samples were chosen for further doping with Nd3+. The maximum Sa and Sr values based on the LIR (IEu/INd) function were 0.67 K-1 (at 80 K) and 0.86 %·K-1 (at 154 K), respectively. As it was mentioned above, the sin-gle-doped YF3: Eu3+ (2.5. %) nanoparticles showed the linearly decreasing τdecay (T) function (5D0 – 7F1 emission). The main idea of Nd3+ co-doping was to increase this slope value (as well as the sensitivity) by increasing the rate of τdecay (T) descent via the addition of one more tempera-ture-dependent channel of 5D0 excited state depopulation. Indeed, we managed to increase the slope (Sa) up to 180·10-4 K-1 at 80 K. This result is one of the highest compared to the world analogs.

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Cellular uptake and cytotoxicity of unmodified Pr3+:LaF3 nanoparticles

Cited by 17 publications

References 37 publications

CeF3-YF3-TbF3 Nanoparticle-Polymer–“Radachlorin” Conjugates for Combined Photodynamic Therapy: Synthesis, Characterization, and Biological Activity

CeF3-YF3-TbF3 Nanoparticle-Polymer–“Radachlorin” Conjugates for Combined Photodynamic Therapy: Synthesis, Characterization, and Biological Activity

Stable Aqueous Colloidal Solutions of Nd3+: LaF3 Nanoparticles, Promising for Luminescent Bioimaging in the Near-Infrared Spectral Range

Spectral-Kinetic Characterization of YF3: Eu3+ and YF3: (Eu3+, Nd3+) Nanoparticles for Optical Temperature Sensing

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