Cellular uptake and targeting of low dispersity, dual emissive, segmented block copolymer nanofibers

Abstract

<p>Polymer-based nanoparticles show substantial promise in the treatment and diagnosis of cancer and other diseases. Herein we report an exploration of the cellular uptake of tailored, low dispersity segmented 1D...</p>

Emerging applications for living crystallization-driven self-assembly

“…This has now been achieved for a variety of crystallizable core-forming blocks, such as PFDMS, 250,253,254 polycarbonate, 62 PDHF, 251 PCL, 169,255 PLLA, 252,[256][257][258] , PE, 70,72 OPV. 259 Watersoluble low dispersity triblock fiber-like comicelles with a PFDMS core have also been prepared by living CDSA.…”

“…Segmented C-B-A-B-C pentablock 1D nanofibers were fabricated from BCPs with a PDHF core-forming segments and PEG coronal blocks that were functionalised with different terminal groups. 251 Micelle tracking can be achieved by attaching a far-red BODIPY fluorophore to the endgroup of the PEG in the B segments (see Figure 6b). In addition, folic acid was attached to the terminal C segments to give micelles with spatially distinct functionality.…”

Direct formation of nano-objects via in situ self-assembly of conjugated polymers

“…84 Some of these polymers may be well suited for INCP, such as oligo( p-phenylene ethynylene) (which forms nanowires) 85 and poly(9,9-dihexylfluorene) (which forms spherical nanoparticles and nanowires). [86][87][88][89] Other polymers may be more challenging to adapt to INCP, such as P3HT (which was previously utilized as the soluble block in INCP), despite its ability to form nanofibers and 2Drectangles using other methods. 61,62,[90][91][92][93][94][95] Similarly, poly(3octylthiophene) (which forms nanowires) 96 and poly [3-(2,5,8,11-tetraoxatridecanyl)thiophene] (which forms nanoribbons) 97 would also be challenging due to their side chains which provide good solubility.…”

Patchy Micelles with a Crystalline Core: Self-Assembly Concepts, Properties, and Applications

“…Inducing secondary crystallization of a poly(3-(2’-hexylethyl)thiophene) (P3EHT) corona block even rendered solid-state donor–acceptor heterojunctions possible ( Figure 3 c) [ 105 ]. These materials bear a high potential for applications in optoelectronics, device fabrication, and sensing [ 123 ].…”