Cellular uptake of functionalized carbon nanotubes is independent of functional group and cell type

Insights into the biomedical effects of carboxylated single-wall carbon nanotubes on telomerase and telomeres

“…Besides, we have demonstrated that SWNTs can enter the living cells in an energy and lysosome-dependent pathway, and pierce into the nucleus (Supplementary Fig. S7), consistent with previous reports [24][25][26] . More direct evidence for the telomeric localization of SWNT in the nuclei has also been provided (Fig.…”

“…The intriguing in vitro inhibition results prompted us to investigate whether SWNTs could inhibit telomerase activity in living cancer cells. Increasing evidence has shown that SWNTs can enter cells through the lipid bilayer, and interact with organelles or even localize within the cell nucleus [24][25][26] . Moreover, it has also been demonstrated that the nature of the functional group on the CNT surface does not determine whether functionalized CNTs are internalized or not 25 .…”

“…Increasing evidence has shown that SWNTs can enter cells through the lipid bilayer, and interact with organelles or even localize within the cell nucleus [24][25][26] . Moreover, it has also been demonstrated that the nature of the functional group on the CNT surface does not determine whether functionalized CNTs are internalized or not 25 . To further determine the localization of SWNTs within cells, we modified the SWNTs with PEG 1500N and labelled with fluorescein isothocyanate (FITC) as described previously 27 (Supplementary Methods and Supplementary Figs S5-S7).…”

Carbon Nanotubes: a viable drug delivery platform for the treatment of cancer

“…One of the most interesting applications for f-CNTs is their use in the treatment of diseases in areas as oncology, gene delivery, infectious diseases, and vaccines (Karimi, et al 2015). f-NTCs are currently considered a potential biomedical material to vectorization of drugs due to: (1) their ability to across the cellular membrane via passive diffusion in several types of cells, and also through energetically active routes (Kostarelos et al, 2007, Lacerda et al, 2013,(2) extremely high loading capacity due to ultrahigh surface area up to 2600 m2/g (Sun et al,2014), and also by their hollow monolithic structure; in fact, they are one of the nanoparticles with larger capacity of drug entrapment (Mody et al, 2014), (3) rich surface chemistry which enables to simultaneously attach a wide range of molecules with different functions in nanomedicine, for example for targeting and imaging. Therefore f-CNTs represent a versatile structure compared with other nanoparticles,(4) f-NTCs exhibit an optical absorption from visible to NIR, allowing their use in photothermal therapy, which complements the chemotherapy (Wang et al, 2013) and (5) f-CNT as any nanoparticles undergo the EPR effect resulting in an intratumoral accumulation.…”

Les nanotubes de carbone : un nouvel outil contre le cancer

“…Depuis, plusieurs méthodes pour leur synthèse ont été optimisées [3]. Les nanotubes, uniquement constitués d'atomes de carbone, appartiennent à la famille des allotropes du carbone, comme le pement de méthodologies alternatives dans le domaine des traitements anticancéreux [4], ceci grâce à leur capacité à pénétrer dans les cellules [5].…”