2021
DOI: 10.1016/j.ejpb.2020.11.011
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Cellular uptake of polymeric nanoparticles by bovine cumulus-oocyte complexes and their effect on in vitro developmental competence

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Cited by 7 publications
(7 citation statements)
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“…Co‐incubation of NP with eggs and embryos had no harmful effects. [ 24 , 25 , 43 ] NPOv‐embryos transferred in vivo into rabbit uteri had no adverse morphological effect on the endometrium at implantation [ 44 , 45 ] and there was no effect on the number of offspring or body weight at birth.…”
Section: Discussionmentioning
confidence: 99%
“…Co‐incubation of NP with eggs and embryos had no harmful effects. [ 24 , 25 , 43 ] NPOv‐embryos transferred in vivo into rabbit uteri had no adverse morphological effect on the endometrium at implantation [ 44 , 45 ] and there was no effect on the number of offspring or body weight at birth.…”
Section: Discussionmentioning
confidence: 99%
“…In this context, Barkalina et al (2014c) demonstrated that incubation of spermatozoa with MSNPs had minimal impact on DNA integrity, motility, viability, or acrosome morphology. Additionally, PLGA-PEG polymeric NPs encapsulating fluorescein isothiocyanate (FITC) were shown to be taken up by cumulus-enclosed oocytes in a proof-of-concept study ( Goncalves et al, 2020 ). These findings, along with the fact that MSNPs have been shown to be ideal carriers of genetic material (i.e., siRNA and miRNA) ( Pecot et al, 2011 ; Cha et al, 2017 ), raises the prospect that NPs may be an ideal alternative to electroporation or the use of viral vectors for the transfer of genetic material to gametes.…”
Section: Applications Of Nanoparticles In Male Reproductive Health Medicine and Researchmentioning
confidence: 99%
“…Thus, the lactic acid produced from PLGA nanoparticles degradation may be used as a metabolic substrate and may support the cellular antioxidant capacity in in vitro cultured COC (Gonçalves et al, 2021).…”
Section: Effects Of Nanoparticles On Cumulus-oocyte Complexes Matured In Vitromentioning
confidence: 99%
“…These authors reported that Mel‐LNC was more effective that nonencapsulated melatonin, probably because this configuration facilitates the release of melatonin throughout the cells. These melatonin‐loaded lipid‐core nanoparticles can trigger an antioxidant cascade that produces radical scavenging products, minimizing oxidative stress through a variety of mechanisms (Reiter et al, 2016) Gonçalves et al (2021) showed that nanoparticles produced using biocompatible and biodegradable poly‐lactic‐co‐glycolic acid (PLGA) can be taken up by cumulus cells and to a less extent by the enclosed oocytes during in vitro maturation of bovine COC. These authors reported that nanoparticles transfer to the oocyte appears to be via cumulus cells and transzonal projections, and that exposure of COC to PLGA nanoparticles increases embryo cleavage and blastocyst rates.…”
Section: Effects Of Nanoparticles On Cumulus‐oocyte Complexes Matured In Vitromentioning
confidence: 99%
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