Cellulitis, sepsis, acute renal failure and hemolytic anemia with McLeod blood group phenotype.

Furuya, Seiji; Kitazawa, Kunihiko; Ideura, Gen; Toshida, Fumitaka; Shimizu, Shigetaka; Shimojo, Takashi; Sakai, Toshiaki; Ishiguro, Jun; Miyahara, Takashige; Misawa, Takuo; Noguchi, Osamu

doi:10.2169/naika.92.140

Cited by 2 publications

(2 citation statements)

References 4 publications

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“…Acute kidney injury (AKI) is found in 5% of all hospitalized patients and in up to 50% of patients with sepsis . AKI is defined as “functional and structural disorders or signs of renal damage including any defect from blood and urine test, or tissue imaging that is less than 3 months” .…”

Section: Introductionmentioning

confidence: 99%

Nephropreventing effect of hypoxia‐inducible factor 1α in a rat model of ischaemic/reperfusion acute kidney injury

Wang

Liu

et al. 2018

Clin Exp Pharma Physio

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Acute kidney injury (AKI) occurs in 5% of hospitalized patients and in 50% of sepsis patients with acute renal dysfunction. However, there have been no safe and effective therapeutic strategies. The hypoxia condition is closely related to renal injury and function under AKI. As hypoxia-inducible factor 1α (HIF-1α) is critical for the cellular response to hypoxia, we investigated the protective effect of HIF-1α in a rat AKI model. We found that HIF-1α injection improved the survival of rat with AKI, and the level of creatinine and blood urea nitrogen (BUN) was also increased. Our data showed that HIF-1α treatment significantly alleviated ischaemic/reperfusion injury to kidney tubules and nephrocytes. We also found the downstream factors, such as EPOR, VEGF, and PHD3, were also upregulated by HIF-1α. Finally, it was observed that HIF-1α treatment also increased the percentage of adult resident progenitor cells (ARPC) in vitro and in vivo. In conclusion, HIF-1α plays a protective role in the ischaemic AKI model through stimulating the proliferation of ARPC, and our study provided a potential therapeutic strategy for AKI.

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Section: Introductionmentioning

confidence: 99%

Nephropreventing effect of hypoxia‐inducible factor 1α in a rat model of ischaemic/reperfusion acute kidney injury

Wang

Liu

et al. 2018

Clin Exp Pharma Physio

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“…Acute kidney insufficiency (AKI), mainly found in patients with sepsis or acute-phase inflammatory diseases, 43,44 is defined as functional and/or structural renal disorders directly related to decreased blood flow and/or tubulointerstitial hypoxia; this process, caused by renal ischemia, results from low blood pressure, nephrotoxic drugs, a renal inflammatory process and urinary flow blockage. [45][46][47] The prolonged process of hypoxia alters tubular epithelial cells and may aggravate the disease, besides leading to the onset of CKD.…”

Section: Hif and Its Relation To Chronic Renal Diseasesmentioning

confidence: 99%

Role of hypoxia‐inducible factor 1α as a potential biomarker for renal diseases—A systematic review

Encinas

Foncesca

Perez

et al. 2019

Cell Biochemistry & Function

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Renal cells need oxygen for homeostasis; it is known for adjusting cellular functioning and the energy obtainment have a broad relationship with cellular respiration, through the O2 bioavailability. O2 homeostasis regulation in the kidney is mediated by hypoxia‐inducible factors (HIFs). HIF is divided into three α isoforms, represented by HIF‐1α, HIF‐2α, and HIF‐3α in addition to three paralogs of HIF‐1β; these are involved in some metabolic processes, as well as in the pathogenesis of several diseases. Renal biopsy analyses of patients and experimental animal models aim to understand the relationship between HIF and protection against developing renal diseases or the induction of their onset, being thus this molecule can be considered a potential biomarker of renal disease. We carried out a systematic review to which we included studies on HIF‐1α and renal disease in the last 5 years (2013‐2018) in researches with humans and/or animal model through searches in three databases: LILACS, PubMed, and SciELO by two researchers. We obtained 22 articles that discussed the relationship with HIF as inductor or protector against renal disease and no relation between HIF and renal. We observed controversies remain regarding the relation between of HIF with renal diseases; this may be related to the different intracellular pathways mediated by HIF‐1α, thereby determining differentiated cellular responses.

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Cellulitis, sepsis, acute renal failure and hemolytic anemia with McLeod blood group phenotype.

Cited by 2 publications

References 4 publications

Nephropreventing effect of hypoxia‐inducible factor 1α in a rat model of ischaemic/reperfusion acute kidney injury

Nephropreventing effect of hypoxia‐inducible factor 1α in a rat model of ischaemic/reperfusion acute kidney injury

Role of hypoxia‐inducible factor 1α as a potential biomarker for renal diseases—A systematic review

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