Cellulose acetate butyrate/poly(caprolactonetriol) blends: Miscibility, mechanical properties, and in vivo inflammatory response

Abstract

This study reports the results of the characterization of cellulose acetate butyrate and polycaprolactone-triol blends in terms of miscibility, swelling capacity, mechanical properties, and inflammatory response in vivo. The cellulose acetate butyrate film was opaque and rigid, with glass transition (T g ) at 134℃ and melting temperature of 156℃. The cellulose acetate butyrate/polycaprolactone-triol films were transparent up to a polycaprolactone-triol content of 60%. T g of the cellulose acetate butyrate films decreased monotonically as polycaprolactone-triol was added to the blend, thus indicating miscibility. FTIR spectroscopy revealed a decrease in intramolecular hydrogen bonding in polycaprolactone-triol, whereas no hydrogen bonding was observed between cellulose acetate butyrate and -OH from polycaprolactone-triol. The increase in polycaprolactone-triol content in the blend decreased the water uptake. An increase in polycaprolactone-triol content decreased the modulus of elasticity and increased the elongation at break. A cellulose acetate butyrate/polycaprolactone-triol 70/30 blend implanted in rats showed only an acute inflammatory response 7 days after surgery. No change in inflammation mediators was observed.

The Influence of Blending Different Molecular Weights of Cellulose Acetate Butyrate for CO2/N2 Separation

“…This is shown in the higher stretching vibrations of the FTIR in Figure 5 where the hydrophilicity of the membrane surface is enhanced. 22 According to a study, the -OH functional group increases the hydrophilicity of the membrane surface. 12 Thus, the CO 2 permeance of M3 increased.…”

Solubility Behaviour of Cellulose Acetate Butyrate in Mixture of Solvents

“…To establish a relationship between dielectric constant of mixed solvents and solvent composition, a method usually used by researchers was applied to calculate the dielectric constant of a binary mixture: (5) whereε m ,ε 1 and ε 2 are the dielectric constants of the mixture and solvents 1 and 2, respectively, ϕ 1 and ϕ 2 are the volume (weight or mole) fractions of solvents 1 and 2 in the mixture. Since ϕ 2 = 1-ϕ 1 , equation 5 could be rearranged as: (6) where M 0 and M 1 are the intercept and slope of the equation [23]. In this study the values for ε 1 and ε 2 were selected from literature data [24,25].…”

“…To merge the biodegradability and biocompatibility of the natural polymers with the processability of the synthetic polymers in order to design new implants, tissue scaffolds or drug delivery systems, some authors studied the modifications in physical properties of CAB in blends with miscible partners. Thus, it was found that cellulose acetate butyrate was miscible with poly(butylene succinate) in chloroform [2], poly(vinylidene fluoride) in N,Ndimethylformamide [3], poly(methylmethacrylate) in N,Ndimethylformamide [4], poly(vinylpyrrolidone) in N,Ndimethylformamide [5] or poly(caprolactonetriol) in acetone [6]. Usually, their miscibility was based on intermolecular H-bonds or electrostatic interactions.…”

Dispositivo implantável de EUDRAGIR/PCL-T/ Diclofenaco de sódio: caracterização mecânica, liberação do fármaco e atividade anti-inflamatóriain vivo

“…Studies show that the PCL-T can provide a plasticizing effect on polymer materials. 24 This behavior is associated with reduced molar weight and the large number of hydroxyl groups in its chemical structure favoring the intercalation within the polymer chains, and the formation of chemical bonds between them. The chemical structure of Eudragit RS shows a large number of carbonyls available to make hydrogen bonds with the hydroxyl groups of PCL-T, which explains the plasticizing effect.…”