Cellulose and lignin as propitious candidates for preparation of hydrogels for pharmaceutical applications

Barzegar, Shayan; Monfared, M H Aryaie; Hubbe, Martin A.

doi:10.1016/j.mtcomm.2022.104617

Cited by 6 publications

(7 citation statements)

References 93 publications

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“…The use of cellulose and Perspective Chapter: Introduction to Hydrogels -Definition, Classifications, Applications... DOI: http://dx.doi.org/10.5772/intechopen.1005061 lignin, their chemical interactions in producing hydrogels, and the applications and properties that make these two polymers so vital. Various applications can benefit from the incorporation of cellulose or lignin structures into hydrogels to develop unique or exceptional characteristics [15].…”

Section: Pharmaceuticalsmentioning

confidence: 99%

Perspective Chapter: Introduction to Hydrogels – Definition, Classifications, Applications and Methods of Preparation

Maleki,

Ghamari Kargar,

Sedigh Ashrafi

et al. 2024

Ionic Liquids - Recent Advances [Working Title]

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Hydrogel products are a group of polymeric materials that possess a hydrophilic structure, allowing them to retain significant amounts of water within their three-dimensional networks. The development of new materials is crucial for advancing technologies, and this often involves the innovative combination of existing components. A combination that incorporates both a polymer hydrogel network and nanoparticles can be achieved by combining metals, non-metals, metal oxides, and polymeric moieties. The composite material’s functionality will be enhanced by this amalgamation, which has applications in various fields such as catalysis, electronics, biosensing, drug delivery, nano-medicine, and environmental remediation. The incorporation of nanoparticles into hydrogels can result in synergistic property enhancements, such as improved mechanical strength of the hydrogel and a reduction in nanoparticle aggregation. These mutually beneficial effects have attracted significant interest from multidisciplinary research groups over the past decade. In this chapter, we delve into recent advancements in nanoparticle-hydrogel composites, focusing on their synthesis, design, potential applications, and the inherent challenges associated with these exciting materials.

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Section: Pharmaceuticalsmentioning

confidence: 99%

Perspective Chapter: Introduction to Hydrogels – Definition, Classifications, Applications and Methods of Preparation

Maleki,

Ghamari Kargar,

Sedigh Ashrafi

et al. 2024

Ionic Liquids - Recent Advances [Working Title]

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“…18 Moreover, the three-dimensional structure of lignin combined with its multifunctional groups, such as phenolic hydroxyl, made it an ideal green cross-linking agent. 19 As a result, the highly rigid structure combined with the unique 3D polyfunctional groups enabled lignin to be an ideal structural enhancer for cellulose aerogels. Currently, about 50 million tons of lignin were produced from pulping industry each year, but only about 2% was used for high-value products, and the remainder is burned as low-value fuels.…”

Section: Introductionmentioning

confidence: 99%

“…Lignin displayed high rigidity, which was derived from (1) the strong π–π stacking of aromatic ring structure, aliphatic and aromatic hydroxyl and quinone groups, which enhanced intermolecular forces, (2) its three-dimensional multiaromatic ring structure, which also enhanced the friction between molecular chains and reduced the free volume of molecular chains . Moreover, the three-dimensional structure of lignin combined with its multifunctional groups, such as phenolic hydroxyl, made it an ideal green cross-linking agent . As a result, the highly rigid structure combined with the unique 3D polyfunctional groups enabled lignin to be an ideal structural enhancer for cellulose aerogels.…”

Section: Introductionmentioning

confidence: 99%

“Rigid-Flexible” Anisotropic Biomass-Derived Aerogels with Superior Mechanical Properties for Oil Recovery and Thermal Insulation

Tan,

Yoo,

Yang

et al. 2023

ACS Appl. Mater. Interfaces

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Aerogels with low density, high mechanical strength, and excellent elasticity have a wide potential for applications in wastewater treatment, thermal management, and sensors. However, the fabrication of such aerogels from biomass materials required complex preparation processes. Herein, a sustainable and facile strategy was reported to construct lignin/ cellulose aerogels (LCMA) with three-dimensional interconnected structures by introducing homologous lignin with a polyphenyl propane structure as a structural enhancer through a top-down directional freezing approach, prompting a 2036% enhancement in compressive modulus and an 8−12-fold increase in oil absorption capacity. In addition, the hydrophobic aerogels with superelasticity were achieved by combining the aligned polygon-like structure and flexible silane chains, which exhibited remarkable compressional fatigue resistance and superhydrophobicity (WCA = 168°). Attributed to its unique pore design and surface morphology control, the prepared aerogel exhibited excellent performance in immiscible oil−water separation and water-in-oil emulsion separation. Due to the ultra-low density (8.3 mg•cm −3 ) as well as high porosity (98.87%), the obtained aerogel showed a low thermal conductivity (0.02565 ± 0.0024 W•m −1 •K −1 ), demonstrating a potential in insulation applications. The synthetic strategy and sustainability concept presented in this work could provide guidance for the preparation of advanced biomass-based aerogels with unique properties for a wide range of applications.

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“…16 Lignin and its derivatives have already been used as reinforcing materials, and components for the preparation of hydrogels, because of their outstanding biocompatibility and thermal stability. 17,18 The special structure of lignin and its large number of benzene rings make its derived hydrogels usually exhibit good toughness. 19,20 For example, the composite hydrogels containing ligninnanoparticle are prepared via didiol-borax linkages and polyvinyl alcohol and cellulose nanofibrils by Bian et al 21 and the results showed that lignin nanoparticle can increase the G 0 and G 00 values of the hydrogel due to the nature of anti-aggregation and super-elasticity.…”

Section: Introductionmentioning

confidence: 99%

“…The high‐strength xylan composite was prepared by introducing CNF and the maximum tensile strength of the hydrogel can reach 31.03 kPa 16 . Lignin and its derivatives have already been used as reinforcing materials, and components for the preparation of hydrogels, because of their outstanding biocompatibility and thermal stability 17,18 . The special structure of lignin and its large number of benzene rings make its derived hydrogels usually exhibit good toughness 19,20 .…”

Section: Introductionmentioning

confidence: 99%

Effect of different modified lignins on the properties of xylan composite hydrogels

Dou,

Wang,

Liu

et al. 2023

J of Applied Polymer Sci

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To improve the mechanical properties of hemicellulose hydrogel, a green, adjustable mechanical property, high swelling ratio (SR) composite hydrogel was successfully prepared by using modified lignin as a reinforcing agent. The structure and characteristics of the composite hydrogels were investigated by TGA, FTIR, SEM, rheological analysis, and SR. It can be found that the modified lignin could significantly improve the mechanical properties of the composite hydrogels. The maximum compressive stress of unmodified lignin hydrogel was 61.72 kPa and the compressive deformation was 75%. Compared with the unmodified lignin hydrogel, the mechanical properties were significantly improved, with the maximum compressive stress of the modified lignin hydrogel was 145.2 kPa and the compressive deformation was up to 90%. After adding modified lignin, the SR of the as‐prepared hydrogel was up to 155.17 g/g, which was much higher than that of unmodified lignin hydrogel (105.79 g/g). The composite hydrogel had good antioxidant properties, and the free radical removal rate can reach 85.3%, which is twice as much as that without the modified lignin. With cost‐effective lignin as a reinforcing agent, the as‐prepared hemicellulose hydrogel with adjustable mechanical properties is favorable for great application potential.

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Cellulose and lignin as propitious candidates for preparation of hydrogels for pharmaceutical applications

Cited by 6 publications

References 93 publications

Perspective Chapter: Introduction to Hydrogels – Definition, Classifications, Applications and Methods of Preparation

Perspective Chapter: Introduction to Hydrogels – Definition, Classifications, Applications and Methods of Preparation

“Rigid-Flexible” Anisotropic Biomass-Derived Aerogels with Superior Mechanical Properties for Oil Recovery and Thermal Insulation

Effect of different modified lignins on the properties of xylan composite hydrogels

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