Cellulose-Based Hydrogels for Medical/Pharmaceutical Applications

Ciolacu, Diana; Suflet, Dana Mihaela

doi:10.1016/b978-0-444-63774-1.00011-9

Cited by 52 publications

(49 citation statements)

References 133 publications

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“…Cellulose-based hydrogels can be easily prepared either by interactions of physical nature (mechanical chain entanglements, van der Waals interaction, hydrogen bridges, hydrophobic or electronic associations) or by chemical cross-linking (with crosslinking agents) [ 69 ]. Physical gelation involves the self-association of cellulose chains due to preferential cellulose–cellulose interactions and not cellulose-solvent, often accompanied by a micro-phase separation.…”

Section: Cellulose-based Hydrogels In Drug Deliverymentioning

confidence: 99%

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Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

Ciolacu¹,

Nicu²,

Ciolacu

2020

Materials

140

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Hydrogels, three-dimensional (3D) polymer networks, present unique properties, like biocompatibility, biodegradability, tunable mechanical properties, sensitivity to various stimuli, the capacity to encapsulate different therapeutic agents, and the ability of controlled release of the drugs. All these characteristics make hydrogels important candidates for diverse biomedical applications, one of them being drug delivery. The recent achievements of hydrogels as safe transport systems, with desired therapeutic effects and with minimum side effects, brought outstanding improvements in this area. Moreover, results from the utilization of hydrogels as target therapy strategies obtained in clinical trials are very encouraging for future applications. In this regard, the review summarizes the general concepts related to the types of hydrogel delivery systems, their properties, the main release mechanisms, and the administration pathways at different levels (oral, dermal, ocular, nasal, gastrointestinal tract, vaginal, and cancer therapy). After a general presentation, the review is focused on recent advances in the design, preparation and applications of innovative cellulose-based hydrogels in controlled drug delivery.

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Section: Cellulose-based Hydrogels In Drug Deliverymentioning

confidence: 99%

“…Various crosslinking agents and catalysts are used for the chemical crosslinking of cellulose derivatives. The most used crosslinking agents are dialdehydes, acetals, polycarboxylic acids, epichlorohydrin and polyepichlorohydrin [ 69 ].…”

Section: Cellulose-based Hydrogels In Drug Deliverymentioning

confidence: 99%

Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

Ciolacu¹,

Nicu²,

Ciolacu

2020

Materials

140

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“…The 3D crosslinks in hydrogel materials serve to maintain the overall integrity of the hydrogel structure and its ability to swell in water. The interactive features responsible for the water uptake process include capillary, osmotic, and hydration forces that are counter-balanced by various intermolecular forces (e.g., polymer-polymer, solvent-polymer, and solvent-solvent interactions) exerted by the crosslinked polymer chains that limit expansion [ 28 ]. Thus, the presence of polar groups in the polymer units (e.g., –NH 2 , –COOH, –OH, –CONH 2 , –CONH, and –SO 3 H) impart a hydrophilic character to the polymer network that favours hydration.…”

Section: Fabrication Of Bio-based Hydrogelsmentioning

confidence: 99%

A Review on the Design and Hydration Properties of Natural Polymer-Based Hydrogels

2021

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Hydrogels are hydrophilic 3D networks that are able to ingest large amounts of water or biological fluids, and are potential candidates for biosensors, drug delivery vectors, energy harvester devices, and carriers or matrices for cells in tissue engineering. Natural polymers, e.g., cellulose, chitosan and starch, have excellent properties that afford fabrication of advanced hydrogel materials for biomedical applications: biodegradability, biocompatibility, non-toxicity, hydrophilicity, thermal and chemical stability, and the high capacity for swelling induced by facile synthetic modification, among other physicochemical properties. Hydrogels require variable time to reach an equilibrium swelling due to the variable diffusion rates of water sorption, capillary action, and other modalities. In this study, the nature, transport kinetics, and the role of water in the formation and structural stability of various types of hydrogels comprised of natural polymers are reviewed. Since water is an integral part of hydrogels that constitute a substantive portion of its composition, there is a need to obtain an improved understanding of the role of hydration in the structure, degree of swelling and the mechanical stability of such biomaterial hydrogels. The capacity of the polymer chains to swell in an aqueous solvent can be expressed by the rubber elasticity theory and other thermodynamic contributions; whereas the rate of water diffusion can be driven either by concentration gradient or chemical potential. An overview of fabrication strategies for various types of hydrogels is presented as well as their responsiveness to external stimuli, along with their potential utility in diverse and novel applications. This review aims to shed light on the role of hydration to the structure and function of hydrogels. In turn, this review will further contribute to the development of advanced materials, such as “injectable hydrogels” and super-adsorbents for applications in the field of environmental science and biomedicine.

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“…The cross-linking reaction of cellulose increases the specific degree of swelling and stable structure [19]. Epichlorohydrin (ECH) is a cross-linking agent whose reaction is catalyzed by bases (NaOH, LiOH, etc.)…”

Section: Synthesis and Characterization Of Superabsorbent Hydrogelsmentioning

confidence: 99%

Synthesis and Characterization of Controlled-Release Urea Fertilizer from Superabsorbent Hydrogels

et al. 2020

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It is very important to develop controlled-release fertilizers to ensure efficiency and environmental protection. This study aims to make a superabsorbent hydrogel-based controlled-release urea fertilizer. Superabsorbent hydrogels were prepared from the cellulose of corn cobs cross-linking with epichlorohydrin, and then an amount of urea as a fertilizer was stored inside the hydrogels (GEL-A). The GEL-A functionalization with carboxy-methyl was also carried out in this study to improve the hydrophilicity of hydrogels (GEL-B). GEL-A and GEL-B were immersed in water at a certain pH and temperature range and the urea concentration released from the hydrogels was monitored by a spectrophotometer. The results showed that the urea released by GEL-A and GEL-B was not much different. Respectively, the urea efficiency of GEL-A and GEL-Bwas around 5.29% and 5.56% for 180 min. The urea released from both hydrogels was not significantly affected by changes in the temperature of the solution. Urea release was influenced by pH, and the rate of urea release of GEL-B was faster than GEL-A, so pH control was needed in the application of this slow-release fertilizer.

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Cellulose-Based Hydrogels for Medical/Pharmaceutical Applications

Cited by 52 publications

References 133 publications

Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

A Review on the Design and Hydration Properties of Natural Polymer-Based Hydrogels

Synthesis and Characterization of Controlled-Release Urea Fertilizer from Superabsorbent Hydrogels

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