Cellulosic Aerogels

Liebner, Falk; Haimer, Emmerich; Potthast, Antje; Rosenau, Thomas

doi:10.1002/9781118229484.ch2

Cited by 9 publications

(6 citation statements)

References 201 publications

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“…The average fibril diameter within the structure of the NA is calculated based on the BET surface area [47] and is estimated to be 17 nm. Pore size by gas absorption-mediated nanopore assessment of the NAs revealed an average pore diameter of 11 nm, which is consistent with a mesoporous and interconnected open porous structure that is usually found in cellulose II aerogels [68,69]. The porosity (99%) and density 12 mg/cm 3 , were calculated based on Equations (8) and (9), respectively.…”

Section: Resultssupporting

confidence: 69%

“…On the other hand, the BET SSA analysis of the NA indicated an average pore diameter of 11 nm, which is in agreement with a predominantly mesoporous pattern. It has been previously noted that a combination of techniques is required to identify the “true” range of pore sizes present in NA structures due to the fragility of these lightweight scaffolds [69] whose interconnected nanofibrillar architecture can be readily observed at the 500-nm scale. …”

Section: Resultsmentioning

confidence: 99%

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Preparation, Characterization and Activity of a Peptide-Cellulosic Aerogel Protease Sensor from Cotton

Edwards

Fontenot

Prevost

et al. 2016

Sensors

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Nanocellulosic aerogels (NA) provide a lightweight biocompatible material with structural properties, like interconnected high porosity and specific surface area, suitable for biosensor design. We report here the preparation, characterization and activity of peptide-nanocellulose aerogels (PepNA) made from unprocessed cotton and designed with protease detection activity. Low-density cellulosic aerogels were prepared from greige cotton by employing calcium thiocyanate octahydrate/lithium chloride as a direct cellulose dissolving medium. Subsequent casting, coagulation, solvent exchange and supercritical carbon dioxide drying afforded homogeneous cellulose II aerogels of fibrous morphology. The cotton-based aerogel had a porosity of 99% largely dominated by mesopores (2–50 nm) and an internal surface of 163 m2·g−1. A fluorescent tripeptide-substrate (succinyl-alanine-proline-alanine-4-amino-7-methyl-coumarin) was tethered to NA by (1) esterification of cellulose C6 surface hydroxyl groups with glycidyl-fluorenylmethyloxycarbonyl (FMOC), (2) deprotection and (3) coupling of the immobilized glycine with the tripeptide. Characterization of the NA and PepNA included techniques, such as elemental analysis, mass spectral analysis, attenuated total reflectance infrared imaging, nitrogen adsorption, scanning electron microscopy and bioactivity studies. The degree of substitution of the peptide analog attached to the anhydroglucose units of PepNA was 0.015. The findings from mass spectral analysis and attenuated total reflectance infrared imaging indicated that the peptide substrate was immobilized on to the surface of the NA. Nitrogen adsorption revealed a high specific surface area and a highly porous system, which supports the open porous structure observed from scanning electron microscopy images. Bioactivity studies of PepNA revealed a detection sensitivity of 0.13 units/milliliter for human neutrophil elastase, a diagnostic biomarker for inflammatory diseases. The physical properties of the aerogel are suitable for interfacing with an intelligent protease sequestrant wound dressing.

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Section: Resultssupporting

confidence: 69%

Section: Resultsmentioning

confidence: 99%

Preparation, Characterization and Activity of a Peptide-Cellulosic Aerogel Protease Sensor from Cotton

Edwards

Fontenot

Prevost

et al. 2016

Sensors

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“…Figure 1 illustrates the general pathway of synthesis of bio-aerogels. Interest in research, development and applications of the bio-aerogels with intriguing properties is rapidly growing [19,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69]. Mostly, they are used as carriers, catalysts and supporting or template materials.…”

Section: Introductionmentioning

confidence: 99%

Review on the Production of Polysaccharide Aerogel Particles

et al. 2018

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A detailed study of the production of polysaccharide aerogel (bio-aerogel) particles from lab to pilot scale is surveyed in this article. An introduction to various droplets techniques available in the market is given and compared with the lab scale production of droplets using pipettes and syringes. An overview of the mechanisms of gelation of polysaccharide solutions together with non-solvent induced phase separation option is then discussed in the view of making wet particles. The main steps of particle recovery and solvent exchange are briefly described in order to pass through the final drying process. Various drying processes are overviewed and the importance of supercritical drying is highlighted. In addition, we present the characterization techniques to analyse the morphology and properties of the aerogels. The case studies of bio-aerogel (agar, alginate, cellulose, chitin, κ-carrageenan, pectin and starch) particles are reviewed. Potential applications of polysaccharide aerogel particles are briefly given. Finally, the conclusions summarize the prospects of the potential scale-up methods for producing bio-aerogel particles.

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“…Nanocellulosic aerogels (NA) are lightweight solid materials with low densities, high SSA, and an interconnected open porous structure [117,118], which make them attractive for use in semiocclusive dressings. Nanocellulosic aerogels may be prepared from a variety of cellulose fiber sources including wood and cotton.…”

Section: Nanocellulosic Aerogel-based Sensormentioning

confidence: 99%

Protease Biosensors Based on Peptide-Nanocellulose Conjugates: From Molecular Design to Dressing Interface

J¹

2016

Int J Med Nano Res

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Cellulosic Aerogels

Cited by 9 publications

References 201 publications

Preparation, Characterization and Activity of a Peptide-Cellulosic Aerogel Protease Sensor from Cotton

Preparation, Characterization and Activity of a Peptide-Cellulosic Aerogel Protease Sensor from Cotton

Review on the Production of Polysaccharide Aerogel Particles

Protease Biosensors Based on Peptide-Nanocellulose Conjugates: From Molecular Design to Dressing Interface

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