Cellulosic Nanowhiskers: Preparation and Drug Delivery Application

Abstract

: Nanomaterials have applications in almost every field and among them, green nanomaterials have various biological applications. Green nanomaterials are specifically useful for drug and DNA delivery applications. Considering that cellulose is the most abundant and easily available biomolecules, and it has been used for preparing greener cellulose nanomaterials. Cellulosic nanowhiskers are a cost-effective and green alternative to chemical non-viral gene delivery systems. Cellulose nanowhiskers are commonly extracted from plant sources, and they are generally prepared by sulfuric and hydrochloric acid hydrolysis of plant cellulose. In this review, the topic of cellulose nanowhiskers as green biocompatible materials for gene and drug delivery is discussed with several practical examples.

Nanomaterials Modulating the Fate of Dental-Derived Mesenchymal Stem Cells Involved in Oral Tissue Reconstruction: A Systematic Review

“…International Journal of Nanomedicine 2023:18 5398 nanomaterials are particularly suitable for drug and DNA delivery, eg, cellulose, a readily available biomolecule, is often used as a green alternative to chemical nonviral gene delivery systems. 208 The goal of reconstructive surgery is to restore form and function, and commonly used methods such as microvascular free flap transfers often result in severe pain, sensory nerve disorders, or concomitant scar formation. On the other hand, tissue engineering techniques based on stem cell research can promote the regeneration of hard and soft tissues and induce the reconstruction of defective areas, promising an alternative to current surgical repair techniques.…”

“…Studies have shown that green nanomaterials are particularly suitable for drug and DNA delivery, eg, cellulose, a readily available biomolecule, is often used as a green alternative to chemical nonviral gene delivery systems. 208 …”

Resveratrol nanocrystals-based dissolving microneedles for rheumatoid arthritis

“…Therefore, there is an urgent need to develop a new mode of drug delivery for the treatment of RA, and the emergence of transdermal drug delivery systems has brought new hope to researchers [6][7][8] . Nanocrystals (NC), also known as nanosuspensions are nanostates (1 ~ 1000 nm) in which the drug is stably dispersed with the help of a small amount of surfactant or in the presence of polymeric materials, and contain close to 100% of the drug [9,10] . Nanocrystalline drugs can increase the solubility of insoluble drugs and improve their bioavailability by reducing the particle size and increasing the speci c surface area of drug particles [11][12][13] .…”

Resveratrol nanocrystals based dissolving microneedles with highly efficient for rheumatoid arthritis

“…Therefore, there is an urgent need to develop a new mode of drug delivery for the treatment of RA, and the emergence of transdermal drug delivery systems has brought new hope to researchers [6][7][8] . Nanocrystals (NC), also known as nanosuspensions are nanostates (1 ~ 1000 nm) in which the drug is stably dispersed with the help of a small amount of surfactant or in the presence of polymeric materials, and contain close to 100% of the drug [9,10] . Nanocrystalline drugs can increase the solubility of insoluble drugs and improve their bioavailability by reducing the particle size and increasing the speci c surface area of drug particles [11][12][13] .…”