Celtis tournefortii LAM. Yaprak Özütüyle Gümüş Nanopartiküllerin Hızlı Biyosentezi; Antimikrobiyal ve Antikanser Aktivitelerinin İncelenmesi

Abstract

The usage of metallic nanoparticles are very common. Environmentally friendly approaches in obtaining nanoparticles attract a lot of attention because of their advantages. In this study, an easy and economical biosynthesis of silver nanoparticles (AgNPs) was made with the extract of Celtis tournefortii LAM. leaf. For the characterization of synthesized nanoparticles, Spectrophotometer (UV-vis), Transmission Electron Microscope (TEM), Field Emission Scan Electron Microscopy (FE-SEM), Atomic Power Microscopy (AFM), Electron Disperse X-ray (EDX) Fourier Transformation Infrared Spectroscopy (FT-IR), X-ray Diffraction (XRD), Thermogravimetric and Differential Thermal Analysis (TGA-DTA), Zeta Sizer and Zeta Potential Analysis data were used. As a result of the data analysis, it was determined that the AgNPs had a spherical appearance, an average size distribution of 4.8 nm, had a maximum absorbance at a wavelength of 482.13 nm, a crystal nanosize of 10.95 nm, and a surface charge of -21.6 mV. Inhibition activities of AgNPs on the growth of pathogenic strains were determined by the microdilution method. The results showed that the nanoparticles were effective even at low concentrations. The Minimum Inhibitory Concentration (MIC) value of the tested materials on the growth of the strains was found between 0.03-1.00 µg mL-1. Anticancer activity of AgNPs was investigated on CaCo-2, U118, Skov3 cancer cell lines and healthy cell line HDF by the MTT method.

A comprehensive account on ethnobotany, phytochemistry and pharmacological insights of genus Celtis

“…Silver nanoparticles were also effective against C. albicans growth at 0.03 g/mL, a significantly lower dosage than antibiotics. [ 34 ] Antiulcerogenic activity C. iguanaea Ethanolextract Leaves In vivo The activity was shown to protect from indomethacin, ethanol, and pyloric ligation-induced gastric ulcers in male Swiss mice. The hexane fraction of this extract reduced indomethacin-induced ulcers by suppressing the release of gastric acid, increasing pH, and decreasing acidity without interrupting intestinal motility through the anticholinergic mechanism.…”

“…Morever, low activity was detected against healthy cell line HDF. [ 34 ] Healing wounded C. australis Seeds Ethyl acetate extract In vivo In Sprague-Dawley rats, the wound healing rate was as same as the standard ointment rates. Madécassol® [ 141 ] Hepatoprotective C. tournefortii Fruits Aqueous, 25 % ethanol, and 75 % ethanol In vivo Activity was shown to protect against Cu-induced hepatic cell damage in Wistar Albino rats.…”

“…A wide range of biochemical activities have been revealed by preliminary biological and therapeutic assessments of extracts and secondary metabolites of Celtis species. These encompass anti-cancer, anti-inflammatory, antimicrobial, analgesic, antifungal, antidiabetic, and antioxidant features [ 25 , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] ].…”

Green-Synthesized Characterization, Antioxidant and Antibacterial Applications of CtAC/MNPs-Ag Nanocomposites

“…Dardagan, also known by its scientific name Celtis tournefortii , is a species of flowering plant belonging to the Cannabaceae family. Native to the Middle East, particularly Iran and Iraq, the Dardagan is a small to medium-sized species that can reach heights of up to 15 m. It is known for its distinctive appearance, with dark green, oval leaves and small, round fruits that turn purplish-black when ripe [ 31 , 32 ].…”