Cemento-osseous dysplasia of the jaws in 54 Japanese patients

Kawai, Tohru; Hiranuma, Hiroko; Kishino, Mitsunobu; Jikko, Akitoshi; Sakuda, Masayoshi

doi:10.1016/s1079-2104(99)70303-3

Cited by 84 publications

(71 citation statements)

References 23 publications

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“…There is some evidence that OD arises from cells in the periodontal ligament tissue. 1,5,6 These three variants share some similar clinical, histopathologic, and radiographic features, except for location of the lesions and extension of maxillary involvement, with periapical OD occurring in the anterior mandible, focal OD in isolated areas except in the anterior mandible, and florid OD occurring multifocally, often in both the mandible and the maxilla. 5,7,8 First described by Melrose et al in 1976, 9 florid osseous dysplasia (FOD) is the most exuberant variant of OD.…”

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confidence: 99%

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Clinical, demographic, and radiographic analysis of 82 patients affected by florid osseous dysplasia: an international collaborative study

Pereira

Pires

Lopes

et al. 2016

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Objective. The aim of this study was to correlate the clinical, demographic, and radiographic aspects of 82 cases of florid osseous dysplasia (FOD) from four countries assessed by five reviewers. Study Design. Retrospective data of patients diagnosed with FOD were obtained from archives of five institutes and analyzed according to clinical and radiographic criteria. Results. A total of 82 cases of FOD were included in the study. In the majority (77.5%) of FOD cases, black women were affected. The disease mainly affected the mandible (100%), and the stage of the lesion was directly correlated with the age (P < .05). The rates of convergence showed confluence of assessment in the mandible (posterior), and the highest rate of divergence between the reviewers was in assessing involvement in the maxilla. There were no differences among the characteristics of the lesion provided by the five institutions, except for the variable proportion of black patients affected by the disease. Conclusions. FOD mostly affects the mandible of middle-aged black women, and its stage is correlated with patient age. Although panoramic radiography is used for diagnosis, the divergence in assessment of the maxilla might indicate that this method is not the most suitable to evaluate this area.

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confidence: 99%

“…1 It affects mainly black women in the fifth to sixth decades of life, although it is also seen in whites and Asians. [2][3][4] This group of dysplasia, which is subdivided into three variantsdfocal, periapical, and florid ODdaffects mainly the jaws in the tooth-bearing or edentulous alveolar ridges.…”

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confidence: 99%

Clinical, demographic, and radiographic analysis of 82 patients affected by florid osseous dysplasia: an international collaborative study

Pereira

Pires

Lopes

et al. 2016

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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“…Radiographically, the differential diagnosis includes periapical abscesses, focal sclerosing osteomyelitis, ossifying fibromas, granulomas, pulpal necrosis, and cysts [4][5][6][7]. The broad differential is in part due to the fact that FOD can appear differently based on the chronicity of the lesion [1,[3][4][5].…”

Section: Discussionmentioning

confidence: 99%

“…A key feature of FOD is its association with the periapex as well as previous extraction sites [2,[4][5][6]. And unlike ossifying fibromas, focal osseous dyplasia is not associated with expansion of the jaw nor displacement of the teeth [1,3,4,7].…”

Section: Discussionmentioning

confidence: 99%

Focal Osseous Dysplasia

Potochny

Huber

2011

Head and Neck Pathol

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Focal osseous dysplasia (FOD) is one of the benign fibro-osseous lesions of the jaw bones and the most commonly occuring benign fibro-osseous lesion. This entity occurs more commonly in females and has a predilection for African Americans. Radiographically, the lesion has a variable appearance depending on the duration but may appear as a radiolucent to radiopaque lesion that can be well to poorly defined. Hisotologically, when biopsied, there are fragments of bony trabeculae intermixed with fibrous stroma with incomplete stromal vasculature. The main differential diagnosis is with ossifying fibroma, which is neoplastic while FOD is considered a reactive process. Most patients with FOD may be followed clinically without surgical intervention.Keywords Osseous dysplasia Á Focal osseous dysplasia Á Focal cemento-osseous dysplasia Á Benign fibro-osseous lesions Á Jaw History A 43-year-old male had a history of an incidentally identified lesion in the posterior mandible. Over time, the lesion became more radiopaque, as observed during routine radiographic follow-up examinations. Radiographic FeaturesPanorex view of the oral cavity showed a non-expansile, mixed radiolucent-radiopaque, moderately well-defined lesion in the posterior mandible distal to the #18 tooth (Fig. 1). DiagnosisGrossly, the resected surgical specimen presented as multiple gritty fragments of tan-brown hemorrhagic tissue. Histologic examination on low magnification showed multiple fragments of curvilinear woven bone with intervening moderately cellular fibroblastic stroma in roughly equal proportions and scattered hemorrhagic foci (Fig. 2). Higher magnification revealed thick bony trabeculae without osteoblastic or cementoblastic rimming. There were no foci of inflammation. The stromal fibroblastic spindle cells were loosely arranged with oval nuclei and eosinophilic to clear cytoplasm (Fig. 3). DiscussionBenign fibro-osseous lesions of the jaw encompass a range of clinicopathologic entities, a select few of which can be differentiated by histopathology alone. Knowledge of clinical and radiographic information in conjunction with histopathology is exceedingly important for accurate distinction. As the name implies, fibro-osseous lesions are

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“…Deux formes sont décrites : la forme focale [1], qui touche une dent unique ou des dents adjacentes mais limitée à un seul quadrant et la forme floride [2] qui s'étend sur plus d'un quadrant [3][4][5].…”

Section: Introductionunclassified