Cemento-ossifying fibroma of jaws—correlation of clinical and pathological findings

Abstract

Cemento-ossifying fibroma (COF) belongs to the group of bone-related lesions of the oral cavity. The aim of this study was refine its histologic features and to correlate histopathological picture and clinical behavior of the tumor. The quantity of bone spherules, their cellularity, the existence of hemorrhage, inflammation, and endochondral ossification in the stroma of the tumor were analyzed and correlated with patients main symptoms of ten patients with COF. All patients had swelling that lasted between 3 and 20 months (mean 10.4 months). Other clinical symptoms were facial asymmetry, eye bulb protrusion, and teeth displacement. The evolution of the tumor was longer in the mandible (12.3 months) than in maxilla (9.5 months). The main histomorphological diagnostic criterion for COF was psammoma-like structures. In lesions with longer case history, the number of "psammomatoid" bodies was greater. In lesions with shorter course of the disease, their number was lower and stromal hemorrhage and inflammation were presented. One patient had secondary superposition of aneurysmal bone cyst in the prime COF of mandible. Histological appearance of COF may be influenced by the tumor evolution. A siginificant correlation between the clinical course of the disease and histological parameters has been certified.

Central Cemento-Ossifying Fibroma: Clinical Imaging and Histopathological Diagnosis

“…Clinically, it generally shows as a volumetric asymptomatic increase of slow evolution which affects the region of premolars and molars in the mandible (Chang et al;Trijolet et al, 2011;White & Pharoah, 2014), while radiographically it manifests as a welldefined lesion with radiotransparent and or radiopaque areas which may be associated with divergences or root resorption (Agarwal et al, 2012;Abbas et al, 2017). Treatment consists of surgical removal with a mostly favorable prognosis (Shimamoto et al, 2011;Sopta et al, 2011). The following case report describes the clinical-imaging and histopathological diagnosis of a central cemento-ossifying fibroma.…”

Juvenile Psammomatoid Ossifying Fibroma of Maxillary Sinus: Case Report with Review of Literature

“…However maxillary lesions are more difficult to remove completely because of the quality of bone and larger size of the lesion at the time of presentation [16]. However in our case the lesion was well encapsulated and was completely shelled out from below the cribriform plate, the oropharynx, and nasopharynx without any remnant being left behind.…”

Secondary jaw aneurysmal bone cyst (JABC) – a possible misnomer? A review of literature on secondary JABCs, their pathogenesis and oncogenesis

“…The final compiled list, after excluding articles as per criteria, comprised of 113 articles reporting 250 JABCs. Of these, 23 articles dealt with benign pathology associated with 37 JABCs (Table ), yielding an incidence of 14.8% . Various lesions were found associated with JABCs, amongst which ossifying fibroma (27.1%) was the most common, followed by cement‐ossifying fibroma (21.6%), central giant cell granuloma (16.2%), fibrous dysplasia (16.2%), cementifying fibroma (5.4%), benign osteoblastoma (5.4%), non‐ossifying fibroma (2.7%), benign ameloblastoma (2.7%) and dentigerous cyst (2.7%).…”