CENPA functions as a transcriptional regulator to promote hepatocellular carcinoma progression via cooperating with YY1

Liao, Jingyu; Chen, Zeyu; Chang, Ruizhi; Yuan, Tong; Li, Ganxun; Zhu, Chang; Wen, Jingyuan; Wei, Yi; Huang, Zhao; Ding, Zeyang; Chu, Liang; Liang, Junnan; Zhang, Bixiang

doi:10.7150/ijbs.85656

Cited by 14 publications

(2 citation statements)

References 48 publications

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“…Further details of the role of Nrp2 in cancer have been described in other malignancies [ 91 , 100 , 101 , 102 , 103 , 104 ]. Nrp2 enhances cancer cell survival through the regulation of autophagy and endocytic trafficking, a function distinct from its role as a co-receptor [ 105 ].…”

Section: Neuropilin-2 In Benign and Malignant Lung Processesmentioning

confidence: 99%

Orchestrating Resilience: How Neuropilin-2 and Macrophages Contribute to Cardiothoracic Disease

Dhupar,

Powers,

Eisenberg

et al. 2024

JCM

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Immunity has evolved to balance the destructive nature of inflammation with wound healing to overcome trauma, infection, environmental insults, and rogue malignant cells. The inflammatory response is marked by overlapping phases of initiation, resolution, and post-resolution remodeling. However, the disruption of these events can lead to prolonged tissue damage and organ dysfunction, resulting long-term disease states. Macrophages are the archetypic phagocytes present within all tissues and are important contributors to these processes. Pleiotropic and highly plastic in their responses, macrophages support tissue homeostasis, repair, and regeneration, all while balancing immunologic self-tolerance with the clearance of noxious stimuli, pathogens, and malignant threats. Neuropilin-2 (Nrp2), a promiscuous co-receptor for growth factors, semaphorins, and integrins, has increasingly been recognized for its unique role in tissue homeostasis and immune regulation. Notably, recent studies have begun to elucidate the role of Nrp2 in both non-hematopoietic cells and macrophages with cardiothoracic disease. Herein, we describe the unique role of Nrp2 in diseases of the heart and lung, with an emphasis on Nrp2 in macrophages, and explore the potential to target Nrp2 as a therapeutic intervention.

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Section: Neuropilin-2 In Benign and Malignant Lung Processesmentioning

confidence: 99%

Orchestrating Resilience: How Neuropilin-2 and Macrophages Contribute to Cardiothoracic Disease

Dhupar,

Powers,

Eisenberg

et al. 2024

JCM

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“…Liao and colleagues discovered that CENPA was markedly increased in HCC, and its high expression was associated with a worse prognosis in HCC patients. CENPA was shown to be lactylated at lysine 124 (K124) [128]. Chen showed that MRE11, an important protein involved in homologous recombination (HR), is modified by lactylation at K673 by the CBP acetyltransferase in reaction to DNA damage, and this process relies on ATM phosphorylation [129].…”

Section: Modification Sites Of Lactylationmentioning

confidence: 99%

Lactylation Modification in Cardiometabolic Disorders: Function and Mechanism

Li,

Cai,

Tang

et al. 2024

Metabolites

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Cardiovascular disease (CVD) is recognized as the primary cause of mortality and morbidity on a global scale, and developing a clear treatment is an important tool for improving it. Cardiometabolic disorder (CMD) is a syndrome resulting from the combination of cardiovascular, endocrine, pro-thrombotic, and inflammatory health hazards. Due to their complex pathological mechanisms, there is a lack of effective diagnostic and treatment methods for cardiac metabolic disorders. Lactylation is a type of post-translational modification (PTM) that plays a regulatory role in various cellular physiological processes by inducing changes in the spatial conformation of proteins. Numerous studies have reported that lactylation modification plays a crucial role in post-translational modifications and is closely related to cardiac metabolic diseases. This article discusses the molecular biology of lactylation modifications and outlines the roles and mechanisms of lactylation modifications in cardiometabolic disorders, offering valuable insights for the diagnosis and treatment of such conditions.

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DSN1 Interaction With Centromere‐Associated Proteins Promotes Chromosomal Instability in Hepatocellular Carcinoma

Zhou,

Zhang,

Lian

et al. 2024

Molecular Carcinogenesis

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Hepatocellular carcinoma (HCC) is the most prevalent type of liver cancer. Dosage suppressor of NNF1 (DSN1), a component of the MIS12 kinetochore complex, encodes a kinetochore protein crucial for proper mitotic assembly. The role of DSN1 in HCC remains to be elucidated. In this study, we utilized The Cancer Genome Atlas, the Hepatocellular carcinoma Cell Database, and other databases to analyze DSN1 expression and prognosis in samples from patients with HCC. We investigated the signaling pathways regulated by DSN1 and their implications in HCC. Additionally, we engineered siRNAsiRNA/shRNA/shRNA and overexpression vectors for DSN1 and assessed the specific mechanisms of regulatory pathways of DSN1 in hepatoma cell lines and subcutaneous tumor xenograft model. Our findings revealed that DSN1 expression was significantly upregulated in patients with HCC, correlating with decreased survival rates. Elevated DSN1 expression led to the overproduction of cell cycle‐related proteins through direct interaction with Centromere Protein T. This interaction contributes to chromosomal instability in patients with HCC, resulting in an aberrant cell cycle and fostering the development and progression of HCC. Increased DSN1 expression is pivotal in HCC initiation and progression. Investigating DSN1 offers valuable insights into the pathogenesis, treatment, and prevention of HCC.

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CENPA functions as a transcriptional regulator to promote hepatocellular carcinoma progression via cooperating with YY1

Cited by 14 publications

References 48 publications

Orchestrating Resilience: How Neuropilin-2 and Macrophages Contribute to Cardiothoracic Disease

Orchestrating Resilience: How Neuropilin-2 and Macrophages Contribute to Cardiothoracic Disease

Lactylation Modification in Cardiometabolic Disorders: Function and Mechanism

DSN1 Interaction With Centromere‐Associated Proteins Promotes Chromosomal Instability in Hepatocellular Carcinoma

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