The data revolution is fueled by advances in machine learning, databases, and hardware design. Programmable accelerators are making their way into each of these areas independently. As such, there is a void of solutions that enables hardware acceleration at the intersection of these disjoint fields. This paper sets out to be the initial step towards a unifying solution for in-Database Acceleration of Advanced Analytics (DAnA). Deploying specialized hardware, such as FPGAs, for in-database analytics currently requires hand-designing the hardware and manually routing the data. Instead, DAnA automatically maps a high-level specification of advanced analytics queries to an FPGA accelerator. The accelerator implementation is generated for a User Defined Function (UDF), expressed as a part of an SQL query using a Pythonembedded Domain-Specific Language (DSL). To realize an efficient in-database integration, DAnA accelerators contain a novel hardware structure, Striders, that directly interface with the buffer pool of the database. Striders extract, cleanse, and process the training data tuples that are consumed by a multi-threaded FPGA engine that executes the analytics algorithm. We integrate DAnA with PostgreSQL to generate hardware accelerators for a range of real-world and synthetic datasets running diverse ML algorithms. Results show that DAnA-enhanced PostgreSQL provides, on average, 8.3× end-to-end speedup for real datasets, with a maximum of 28.2×. Moreover, DAnA-enhanced PostgreSQL is, on average, 4.0× faster than the multi-threaded Apache MADLib running on Greenplum. DAnA provides these benefits while hiding the complexity of hardware design from data scientists and allowing them to express the algorithm in ≈30-60 lines of Python.