Centaurium erythraea extract reduces redox imbalance and improves insulin expression and secretion in pancreatic β-cells exposed to oxidative and nitrosative stress

Đorđević, Miloš; Grdović, Nevena; Mihailović, Mirjana; Jovanović, Jelena Arambašić; Uskoković, Aleksandra; Rajić, Jovana; Tolić, Anja; Mišić, Danijela; Šiler, Branislav; Poznanović, Goran; Vidaković, Melita; Dinić, Svetlana

doi:10.2298/abs200127005d

Cited by 7 publications

(1 citation statement)

References 41 publications

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“…The amount was expressed as μg of GSH/mg of protein. In samples, the GSHPx activity was measured by quantifying the rate of H2O2-induced oxidation of GSH to oxidized glutathione catalyzed by glutathione peroxidase (GSHPx) (Miloš et al 2020).…”

Section: Estimation Of Glutathione (Gsh)mentioning

confidence: 99%

Chemomodulatory Potential of n-Hexane Extract of Conyza bonariensis Against Skin Carcinogenesis in Mice Induced by Carcinogens: An in Vitro and in Vivo Study

Naseer,

Imran Aziz,

Asghar

et al. 2022

Phytopharmacological Com.

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Conyza bonariensis (CB) is a cosmopolitan herb, family Asteraceae (Compositeae), commonly known as mrich booti or gulava previously used to cure cancer in traditional medicine. In the present study, n-hexane fraction by CB's triterpenoid constituents was assessed for their cytotoxic property using the human skin carcinoma cell line (SCC-13) and human peripheral blood mononuclear cells (PBMC). The chemo modulatory potential of CB n-hexane was evaluated against skin carcinogenesis in mice induced by (7-12-dimethylbenz(a)antheracene) DMBA and Croton oil. CB n-hexane extract was orally administered at the doses of 3, 6, and 9 mg/kg/day, and 9 mg/kg was also applied locally on mice skin for 16 weeks. The results from cell lines revealed that CB induces cytotoxicity against the SCC-13 cells (IC50=7.5 µM). It was found to be 4.05 times more selective in exerting cytotoxicity against SCC-13 than the PBMC (IC50=30.4 µM). The results from the mice model of skin carcinogenesis have shown that whole plant n-hexane extract administered via oral and topical routes, both reduced the number of precancerous skin papillomas and their incidence. At these concentrations, CB n-hexane also augmented the actions of catalase and superoxide dismutase, glutathione content and reduced the skin lipid peroxidation levels. These outcomes presented the cytotoxic and antioxidative effects of CB n-hexane whole plant extract and also authenticates the traditional assertions and strengthen the technical base of its chemopreventive activity.

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Section: Estimation Of Glutathione (Gsh)mentioning

confidence: 99%

Chemomodulatory Potential of n-Hexane Extract of Conyza bonariensis Against Skin Carcinogenesis in Mice Induced by Carcinogens: An in Vitro and in Vivo Study

Naseer,

Imran Aziz,

Asghar

et al. 2022

Phytopharmacological Com.

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Phytochemical properties, biological activities and medicinal use of Centaurium erythraea Rafn

Menyiy

Guaouguaou

Baaboua

et al. 2021

Journal of Ethnopharmacology

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Antidiabetic effects of polyherbal mixture made of Centaurium erythraea, Cichorium intybus and Potentilla erecta

Petrović

Madić

Stojanović

et al. 2024

Journal of Ethnopharmacology

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Centaurium erythraea extract reduces redox imbalance and improves insulin expression and secretion in pancreatic β-cells exposed to oxidative and nitrosative stress

Abstract: erythraea extract reduces redox imbalance and improves insulin expression and secretion in pancreatic β-cells exposed to oxidative and nitrosative stress.

Cited by 7 publications

References 41 publications

Chemomodulatory Potential of n-Hexane Extract of Conyza bonariensis Against Skin Carcinogenesis in Mice Induced by Carcinogens: An in Vitro and in Vivo Study

Chemomodulatory Potential of n-Hexane Extract of Conyza bonariensis Against Skin Carcinogenesis in Mice Induced by Carcinogens: An in Vitro and in Vivo Study

Phytochemical properties, biological activities and medicinal use of Centaurium erythraea Rafn

Antidiabetic effects of polyherbal mixture made of Centaurium erythraea, Cichorium intybus and Potentilla erecta

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