Centile Curves for Velocity-Time Integral Times Heart Rate as a Function of Ventricular Length: The Use of Minute Distance Is Advantageous to Enhance Clinical Reliability in Children

Solinski, A.; Klusmeier, E.; Horst, J; Körperich, Hermann; Haas, Nikolaus A.; Kececioglu, Deniz; Laser, Kai Thorsten

doi:10.1016/j.echo.2017.09.011

Cited by 11 publications

(12 citation statements)

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“…Both in adults and children, TVI monitoring is recommended in several pathologies [39]. In a reference paper, normal values for TVI are proposed [40]. In our study TVI baseline values were within normal range and after AC-based therapy the values decreased (p<0.001), suggesting that TVI is a sensitive and independent predictor for CIC, as Schmitt et al previous founded [41].…”

Section: Discussionsupporting

confidence: 73%

Cardiotoxicity evaluation in pediatric patients with acute lymphoblastic leukemia – results of prospective study

et al. 2019

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Aim: The chemotherapy protocol for acute lymphoblastic leukemia (ALL) uses low doses of anthracyclines (AC), generally associated with subclinical cardiotoxicity. The aim of our study was to evaluate the serum biomarkers and echocardiography parameters in children with ALL treated with AC in order to determine the most useful element for early detection of cardiotoxicity.Material and methods: In this prospective study, troponin I (TnI) and heart-type fatty acid binding protein (HFABP) were assessed five times during the first year after the onset of ALL. Serial Tissue Doppler Imaging and conventional cardiac echography were performed by two pediatric cardiologists (intraclass correlation coefficient over 0.85 for all measurements) in three periods during the study protocol.Results: We evaluated 48 children with ALL. TnI increased during therapy, without returning to baseline values one year after diagnosis. HFABP did not show significant changes during the study protocol. Left ventricle outflow tract time-velocity integral and peak systolic septal mitral annulus velocity decreased during chemotherapy and returned to baseline levels at one year after diagnosis, while peak systolic tricuspid annulus velocity and excursion, maintained a descending tendency. Early filling transmitral flow velocity and E/A ratio were also transiently influenced by chemotherapy.Conclusions: The study showed signs of transient cardiotoxicity in the left ventricle and diastolic parameters after chemotherapy, compared to right ventricle parameters which maintained low values even one year after diagnosis. TnI proved to be directly proportional to chemotherapy doses but HFABP was not useful in this setting

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Section: Discussionsupporting

confidence: 73%

Cardiotoxicity evaluation in pediatric patients with acute lymphoblastic leukemia – results of prospective study

et al. 2019

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“…Lead positioning was epicardial and the device was placed abdominally in all three patients. Postnatal echocardiographic findings showed that cardiac output was adjusted to the circumstances with aortic velocity time integral (VTI) levels of about 24 cm, resembling values usually found in 7 years old children [4] (Table 1a).…”

Section: Resultsmentioning

confidence: 90%

First clinical experience with the Kora pacemaker system in congenital complete heart block in newborn infants

et al. 2019

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Background To report first clinical experience on three cases of congenital complete heart block and the use of a pacemaker system with a maximum lower rate interval of 95 beats per minute. Methods We retrospectively analyzed three patients treated with a pacemaker system with a maximum lower rate interval of 95 beats per minute suffering from congenital complete heart block. We report a follow up period of 2.9 years, focusing on the patients’ growth, development, and adverse events, as well as pacemaker function. Results In all three patients pacemaker function was impeccable, including minute ventilation sensor rate adaption. All patients showed limited growths as expected, adequate development, good feeding tolerability and circadiane heart rate adaption. One patient experienced skin traction and revision. All patients showed high aortic velocity time integral values after birth. Conclusion The use of a pacemaker system with a maximum lower rate interval of 95 beats per minute in infants suffering from congenital complete heart block and showing high aortic VTI values seems to be feasible and to result in limited growths but adequate development. Electronic supplementary material The online version of this article (10.1186/s12887-019-1494-7) contains supplementary material, which is available to authorized users.

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“…There were studies that suggested evaluating VTI in relation to HR because of strong negative correlations between VTI and HR [15][16][17]. In accordance with this, there was another study that showed a negative correlation, particularly in children <7 years of age [18]. This relationship is likely caused by a predominantly frequency-based regulation of CO and becomes less obvious in larger ventricles that are also able to vary their systolic volume using the Frank-Starling mechanism [19].…”

Section: Online Firstmentioning

confidence: 83%

“…This relationship is likely caused by a predominantly frequency-based regulation of CO and becomes less obvious in larger ventricles that are also able to vary their systolic volume using the Frank-Starling mechanism [19]. The product of VTI and HR (VTI×HR), also called MD, compensates for the fact that VTI values at low HRs will result in comparable CO with those of low VTI values at high HRs [18].…”

Section: Online Firstmentioning

confidence: 99%

Echocardiography of the right ventricle in infancy: Do early feeding practices make a difference?

Abul-Fadl¹,

Amer²,

Darwish³

et al. 2020

IJCH

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Centile Curves for Velocity-Time Integral Times Heart Rate as a Function of Ventricular Length: The Use of Minute Distance Is Advantageous to Enhance Clinical Reliability in Children

Abstract: These new reference values for VTI times heart rate as a function of ventricular length may be of specific clinical value to improve the assessment of cardiac function, therapeutic decision making, and follow-up in pediatric patients with heart disease.

Cited by 11 publications

References 46 publications

Cardiotoxicity evaluation in pediatric patients with acute lymphoblastic leukemia – results of prospective study

Cardiotoxicity evaluation in pediatric patients with acute lymphoblastic leukemia – results of prospective study

First clinical experience with the Kora pacemaker system in congenital complete heart block in newborn infants

Echocardiography of the right ventricle in infancy: Do early feeding practices make a difference?

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