Central activation of catecholamine-independent lipolysis drives the end-stage catabolism of all adipose tissues
Xiao Zhang,
Anurag Majumdar,
Clara Kim
et al.
Abstract:Several adipose depots, including constitutive bone marrow adipose tissue (cBMAT), resist conventional lipolytic cues, making them metabolically non-responsive. However, under starvation, wasting, or cachexia, the body can eventually catabolize these stable adipocytes through unknown mechanisms. To study this, we developed a mouse model of brain-evoked depletion of all fat, including cBMAT, independent of food intake. Genetic, surgical, and chemical approaches demonstrated that depletion of stable fat required… Show more
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