Central administration of l- and d-aspartate attenuates stress behaviors by social isolation and CRF in neonatal chicks

Erwan, Edi; Tomonaga, Shozo; Yoshida, Junki; Nagasawa, Mao; Ogino, Yoichiro; Denbow, D. Michael; Furuse, Mitsuhiro

doi:10.1007/s00726-012-1272-4

Cited by 22 publications

(34 citation statements)

References 36 publications

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“…The results showed that some amino acids were modified only in the telencephalon. Above all, aspartate (L-aspartate and Daspartate in Erwan et al (2012)), arginine (L-arginine in Suenaga et al (2008a)), glutamate (L-glutamate in Yamane et al (2009a)), β-alanine (Tomonaga et al, 2004), glycine and SOP (L-SOP in Asechi et al (2006)) are known to have sedative and/or hypnotic effects when administered by i.c.v. in neonatal chicks.…”

Section: Discussionmentioning

confidence: 99%

Central Administration of Glucose Modifies Brain Amino Acid Metabolism in Neonatal Chicks

et al. 2015

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Intracerebroventricular injection of glucose can induce a sedative effect in chicks under social isolation stress. In addition, central injection of glucose improves memory formation in chicks in the passive avoidance task. In the present study, we confirmed that intracerebroventricular injection of glucose modified aspartate, arginine, glutamate, β-alanine, glycine and serine-ortho-phosphate levels of the telencephalon which are known to induce sedative effects in chicks. In addition, not only glutamate in the telenephalon, one of whose receptors is involved in the formation of memory in chicks, but also its metabolite glutamine was affected. These results suggest that some types of amino acid metabolism may be linked to the functions of glucose in the brain, attenuate the stress response and improve memory formation in chicks.

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Section: Discussionmentioning

confidence: 99%

Central Administration of Glucose Modifies Brain Amino Acid Metabolism in Neonatal Chicks

et al. 2015

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“…However, in addition to essential amino acids, non-essential amino acids may also reduce the effects of psychological and physiological stress in chicks (Erwan et al, 2012(Erwan et al, , 2014a, since their levels have been found to be modified under heat stress Ito et al, 2014). Recently, we reported that D-aspartate showed the potential to reduce body temperature under both thermoneutral temperature (control) and HT conditions in chicks (Erwan et al, 2014b).…”

Section: Introductionmentioning

confidence: 99%

Oral Administration of L-Citrulline, but not L-Arginine or L-Ornithine, Acts as a Hypothermic Agent in Chicks

et al. 2015

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Some amino acids are important regulators of key metabolic pathways and necessary for several physiological functions. However, little is know about thermoregulatory functions of amino acids. In this study, therefore chicks were either centrally or orally administered with L-citrulline (L-Cit), L-arginine (L-Arg) or L-ornithine (L-Orn) to monitor changes in rectal temperature. In Experiment 1, the amino acids (L-Cit, L-Arg and L-Orn) were administered into the left ventricle of the chicks by intracerebroventricular (i.c.v.) injection at a dose of 1 μmol/10 μl to monitor the effects of these amino acids on rectal temperature during 120 min of the experimental period. In Experiment 2, chicks received the same amino acids by oral administration at a dose of 15 mmol/10 ml/kg body weight. In Experiment 3, chicks received three doses of L-Cit (3.75, 7.5 or 15 mmol/10 ml/kg body weight) by oral administration. I.c.v. injection with any of the amino acids studied did not alter body temperature, but oral administration of L-Cit significantly reduced body temperature. Importantly, the highest does effectively reduced body temperature. These results suggest that peripheral L-Cit has a hypothermic function in chicks, which may be a new candidate to minimize high body temperature in poultry during summer heat stress.

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“…We have revealed the differences of L-Asp and D-Asp on stress response, feed intake and regulation of body temperature (Erwan et al, 2012(Erwan et al, , 2013a(Erwan et al, , 2013b(Erwan et al, , 2014. Further it was found that the mechanism of stress attenuating function of L-and D-Asp possibly occurs through different receptors (Erwan et al, 2012(Erwan et al, , 2014b. Koyuncuoğlu et al (1982b) demonstrated that rectal temperature significantly decreased when rats received DAsp or D-plus L-Asp in a 1:1 ratio.…”

Section: Discussionmentioning

confidence: 99%

“…We have previously shown that intracerebroventicular (i.c.v.) injection of either L-or D-Asp clearly attenuated stress responses in layer chicks (Yamane et al, 2009;Erwan et al, 2012Erwan et al, , 2014b and oral administration of D-Asp decreased feed intake, body temperature and altered some plasma metabolites in layer chicks (Erwan et al, 2013a(Erwan et al, , 2014a. Hence, L-or D-Asp may act as a modulator of important physiological functions in chicks.…”

Section: Introductionmentioning

confidence: 99%

“…For instance, suitable nutrients or drugs to reduce high body temperature when exposed to HT should be clarified. Nutrients, especially amino acids, are widely applied as anti-stress agents with regard to psychological and physiological stress (Yamane et al, 2009;Hamasu et al, 2010;Erwan et al, 2012Erwan et al, , 2014b. Amino acid in particular essential amino acids supplementation has been performed in order to overcome heat-stress problems in birds (Mendes et al, 1997;Brake et al, 1998;Willemsen et al, 2011;Dai et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Orally Administered D-Aspartate Depresses Rectal Temperature and Alters Plasma Triacylglycerol and Glucose Concentrations in Broiler Chicks

et al. 2017

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L-Aspartate (L-Asp), D-aspartate (D-Asp) or their chemical conjugates plays important physiological roles in regulating food intake, plasma metabolites and thermoregulation in animals. However, there are very few studies available in layers and no reports have been found in broilers. Broilers are very important commercial birds for meat production, so effects of L-or D-Asp in broilers would provide new physiological insight of this strain. Therefore, the purpose of this study was to determine the effect of oral administration of L-or D-Asp on feed intake, rectal temperature and some plasma metabolites in broiler chicks. Broiler chicks (5 days old) were orally administered with different doses (0, 3.75, 7.5 and 15 mmol/kg body weight) of L-or D-Asp. At 120 min after administration of L-or D-Asp, the blood was immediately collected through the jugular vein. The rectal temperature of chicks was measured at 30, 60 and 120 min after administration using a digital thermometer with an accuracy of ±0.1℃, by inserting the thermistor probe in the rectum to a depth of 2 cm. A repeated-measures two-way ANOVA was applied for the analysis of feed intake and rectal temperature. Plasma metabolites were statistically analyzed by one-way ANOVA and regression equations. The study showed that oral administration of both L-and D-Asp did not alter feed intake. However, D-Asp, but not L-Asp, dose-dependently decreased the rectal temperature in chicks. It was also found that DAsp increased plasma glucose and decreased triacylglycerol concentrations. The changes in plasma metabolites further indicate that D-Asp treatment modulates the energy metabolism in broiler chicks. In conclusion, D-Asp may be a beneficial nutrient not only for layers but also for broilers, since orally administered D-Asp lowered rectal temperature without reducing feed intake.

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Central administration of l- and d-aspartate attenuates stress behaviors by social isolation and CRF in neonatal chicks

Cited by 22 publications

References 36 publications

Central Administration of Glucose Modifies Brain Amino Acid Metabolism in Neonatal Chicks

Central Administration of Glucose Modifies Brain Amino Acid Metabolism in Neonatal Chicks

Oral Administration of L-Citrulline, but not L-Arginine or L-Ornithine, Acts as a Hypothermic Agent in Chicks

Orally Administered D-Aspartate Depresses Rectal Temperature and Alters Plasma Triacylglycerol and Glucose Concentrations in Broiler Chicks

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