Central administration of phosphatidylserine attenuates isolation stress-induced behavior in chicks

Koutoku, Tomoyuki; Takahashi, Hirokazu; Tomonaga, Shozo; Oikawa, Daichi; Saito, Shin; Tachibana, Tetsuya; Han, Liang; Hayamizu, Kohsuke; Denbow, D. Michael; Furuse, Mitsuhiro

doi:10.1016/j.neuint.2005.03.006

Cited by 51 publications

(33 citation statements)

References 31 publications

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“…In brief, chicks (5 days old) were intracerebroventricularly injected either with 1 μmol/10 μl of the above-mentioned amino acids or, for the control, with the same volume of saline. This injection method is not stress-causing (Furuse et al, 1999;Koutoku et al, 2005).…”

Section: Experimental Designmentioning

confidence: 94%

Oral Administration of L-Citrulline, but not L-Arginine or L-Ornithine, Acts as a Hypothermic Agent in Chicks

et al. 2015

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Some amino acids are important regulators of key metabolic pathways and necessary for several physiological functions. However, little is know about thermoregulatory functions of amino acids. In this study, therefore chicks were either centrally or orally administered with L-citrulline (L-Cit), L-arginine (L-Arg) or L-ornithine (L-Orn) to monitor changes in rectal temperature. In Experiment 1, the amino acids (L-Cit, L-Arg and L-Orn) were administered into the left ventricle of the chicks by intracerebroventricular (i.c.v.) injection at a dose of 1 μmol/10 μl to monitor the effects of these amino acids on rectal temperature during 120 min of the experimental period. In Experiment 2, chicks received the same amino acids by oral administration at a dose of 15 mmol/10 ml/kg body weight. In Experiment 3, chicks received three doses of L-Cit (3.75, 7.5 or 15 mmol/10 ml/kg body weight) by oral administration. I.c.v. injection with any of the amino acids studied did not alter body temperature, but oral administration of L-Cit significantly reduced body temperature. Importantly, the highest does effectively reduced body temperature. These results suggest that peripheral L-Cit has a hypothermic function in chicks, which may be a new candidate to minimize high body temperature in poultry during summer heat stress.

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Section: Experimental Designmentioning

confidence: 94%

Oral Administration of L-Citrulline, but not L-Arginine or L-Ornithine, Acts as a Hypothermic Agent in Chicks

et al. 2015

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“…The i.c.v. injection was performed using a microsyringe according to the method of Davis et al (1979) and Koutoku et al (2005). The stress and pain suffered by this method is minimal, as described elsewhere (Koutoku et al, 2005).…”

Section: Animals and Foodmentioning

confidence: 99%

Central Administration of Glucose Modifies Brain Amino Acid Metabolism in Neonatal Chicks

et al. 2015

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Intracerebroventricular injection of glucose can induce a sedative effect in chicks under social isolation stress. In addition, central injection of glucose improves memory formation in chicks in the passive avoidance task. In the present study, we confirmed that intracerebroventricular injection of glucose modified aspartate, arginine, glutamate, β-alanine, glycine and serine-ortho-phosphate levels of the telencephalon which are known to induce sedative effects in chicks. In addition, not only glutamate in the telenephalon, one of whose receptors is involved in the formation of memory in chicks, but also its metabolite glutamine was affected. These results suggest that some types of amino acid metabolism may be linked to the functions of glucose in the brain, attenuate the stress response and improve memory formation in chicks.

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“…Therefore, we thought that the difference in the values of control group in spontaneous activity and distress vocalization was not serious. In addition, the stress and pain suffered by this method is minimal as described elsewhere (Koutoku et al, 2005), so the values between non-injected and saline-injected chicks were not different. We recently reported the effects of i.c.v.…”

Section: Discussionmentioning

confidence: 94%

“…injections were in a volume of 10 μl using a microsyringe according to the method of Davis et al (1979). The stress and pain suffered by this method are minimal as described elsewhere (Koutoku et al, 2005). The molality and volume applied were determined by a previous study (Tsuneyoshi et al, 2007).…”

Section: Preparation Of Drugsmentioning

confidence: 99%

Reverse structure of carnosine-induced sedative and hypnotic effects in the chick under acute stress

et al. 2008

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Central administration of phosphatidylserine attenuates isolation stress-induced behavior in chicks

Cited by 51 publications

References 31 publications

Oral Administration of L-Citrulline, but not L-Arginine or L-Ornithine, Acts as a Hypothermic Agent in Chicks

Oral Administration of L-Citrulline, but not L-Arginine or L-Ornithine, Acts as a Hypothermic Agent in Chicks

Central Administration of Glucose Modifies Brain Amino Acid Metabolism in Neonatal Chicks

Reverse structure of carnosine-induced sedative and hypnotic effects in the chick under acute stress

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