Central Aminergic Function and its Disturbance by Hepatic Disease: The Current Status of L-valine Pharmacotherapy in Metabolic Coma

Riederer, Peter; Kruzik, P.; Kienzl, E.; Kleinberger, G; Jellinger, K. A.; Wesemann, W.

doi:10.1007/978-1-349-05932-4_13

Cited by 4 publications

(2 citation statements)

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“…TRP levels were shown to alter in infarct, hepatic failure, and schizophrenia (Curzon et al. 1973; Riederer et al. 1981; Jellinger and Riederer 1983; Korpi et al.…”

Section: Discussionmentioning

confidence: 99%

“…Still not all proteins degrade in similar manner (Omalu et al 2005), therefore scientist should test such factors ahead. TRP levels were shown to alter in infarct, hepatic failure, and schizophrenia (Curzon et al 1973;Riederer et al 1981;Jellinger and Riederer 1983;Korpi et al 1987). Although we found no influence of pathological factors on TRP, any study of protein/enzymes should be critical.…”

Section: Discussionmentioning

confidence: 99%

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Tryptophan is a marker of human postmortem brain tissue quality

Grünblatt¹,

Monoranu²,

Apfelbacher³

et al. 2009

Journal of Neurochemistry

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Postmortem human brain tissue is widely used in neuroscience research, but use of tissue originating from different brain bank centers is considered inaccurate because of possible heterogeneity in sample quality. There is thus a need for well-characterized markers to assess the quality of postmortem brain tissue. Toward this aim, we determined tryptophan (TRP) concentrations, phosphofructokinase-1 and glutamate decarboxylase activities in 119 brain tissue samples. These neurochemical parameters were tested in samples from autopsied individuals, including control and pathological cases provided by 10 different brain bank centers. Parameters were assessed for correlation with agonal state, postmortem interval, age and gender, brain region, preservation and freezing methods, storage conditions and storage time, RNA integrity, and tissue pH value. TRP concentrations were elevated significantly (p = 0.045) with increased postmortem interval; which might indicate increased protein degradation. Therefore, TRP concentration might be one useful and convenient marker for estimating the quality of human postmortem brain tissue.

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“…TRP levels were shown to alter in infarct, hepatic failure, and schizophrenia (Curzon et al. 1973; Riederer et al. 1981; Jellinger and Riederer 1983; Korpi et al.…”

Section: Discussionmentioning

confidence: 99%