Central AMPK contributes to sleep homeostasis in mice

Chikahisa, Sachiko; Fujiki, Nobuhiro; Kitaoka, Katsuhiko; Shimizu, Noriyuki; Séi, Hiroyoshi

doi:10.1016/j.neuropharm.2009.07.015

Cited by 52 publications

(35 citation statements)

References 29 publications

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“…On a molecular level, adenosine is phosphorylated by adenosine kinase to produce AMP, which activates AMPK, a sensor of AMP/ATP intracellular levels 39 . AMPK is a master regulator of intracellular metabolism and is involved in glucose uptake, lipogenesis and fatty acid oxidation 40 ; sleep deprivation has been reported to lead to elevated levels of phosphorylated AMPK in the hypothalamus 41 . AMPK is both directly and indirectly linked with the circadian clock, demonstrating how interconnected these networks are.…”

Section: Metabolism Sleep and The Clockmentioning

confidence: 99%

The circadian clock: a framework linking metabolism, epigenetics and neuronal function

2012

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The circadian clock machinery is responsible for biological timekeeping on a systemic level. The central clock system controls peripheral clocks through a number of output cues that synchronize the system as a whole. There is growing evidence that changing cellular metabolic states have important effects on circadian rhythms and can thereby influence neuronal function and disease. Epigenetic control has also been implicated in the modulation of biological timekeeping, and cellular metabolism and epigenetic state seem to be closely linked. We discuss the idea that cellular metabolic state and epigenetic mechanisms may work through the circadian clock to potentially regulate neuronal function and to influence disease states.

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Section: Metabolism Sleep and The Clockmentioning

confidence: 99%

The circadian clock: a framework linking metabolism, epigenetics and neuronal function

2012

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“…This kinase is an activator of adenosine monophosphate (AMP)-activated protein kinase (AMPK), a sensor and central mediator of metabolic signals. Consequently, AMPK is phosphorylated, and p-AMPK is increased after SD [12] and hence leads to higher AMPK activity. Pharmacological treatment of mice with AMPK inhibitor and activator modulated EEG delta power indicating that AMPK is involved in the regulation of sleep depth and sleep homeostasis [12].…”

Section: Protein Kinases Sleep and Circadian Rhythmsmentioning

confidence: 99%

“…Consequently, AMPK is phosphorylated, and p-AMPK is increased after SD [12] and hence leads to higher AMPK activity. Pharmacological treatment of mice with AMPK inhibitor and activator modulated EEG delta power indicating that AMPK is involved in the regulation of sleep depth and sleep homeostasis [12]. Recent investigations also point to an involvement of AMPK in the regulation of the circadian oscillator.…”

Section: Protein Kinases Sleep and Circadian Rhythmsmentioning

confidence: 99%

Circadian rhythms and sleep—the metabolic connection

Albrecht

2011

Pflugers Arch - Eur J Physiol

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The circadian system coordinates mammalian physiology and behavior with the environmental light-dark cycle. It allocates sleep to the inactivity phase using various mechanisms involving neurotransmitters, nuclear receptors, and protein kinases. These pathways are related to metabolism, indicating that the circadian system and sleep are connected via metabolic parameters. This suggests that organs other than the brain may "sleep." A hypothetic view on this aspect is presented providing a different perspective on sleep regulation.

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“…AMPK phosphorylation in the brain is reduced during times of day when sleep predominates [34]. Enforced wake caused an increase in phosphorylated AMPK (pAMPK) [34, 39]. …”

Section: Ampk: a Metabolic Indicator For Cellular Energy Chargementioning

confidence: 99%

“…Indeed, AMPK does appear to affect sleep physiology. An AMPK inhibitor attenuated NREMS slow wave activity (SWA) during spontaneous sleep, while an activator enhanced it [39]. These data demonstrate that AMPK is a driver of sleep need.…”

Section: Ampk: a Metabolic Indicator For Cellular Energy Chargementioning

confidence: 99%

A metabolic–transcriptional network links sleep and cellular energetics in the brain

Wisor

2011

Pflugers Arch - Eur J Physiol

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This review proposes a mechanistic link between cellular metabolic status, transcriptional regulatory changes and sleep. Sleep loss is associated with changes in cellular metabolic status in the brain. Metabolic sensors responsive to cellular metabolic status regulate the circadian clock transcriptional network. Modifications of the transcriptional activity of circadian clock genes affect sleep/wake state changes. Changes in sleep state reverse sleep loss-induced changes in cellular metabolic status. It is thus proposed that the regulation of circadian clock genes by cellular metabolic sensors is a critical intermediate step in the link between cellular metabolic status and sleep. Studies of this regulatory relationship may offer insights into the function of sleep at the cellular level.

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Central AMPK contributes to sleep homeostasis in mice

Cited by 52 publications

References 29 publications

The circadian clock: a framework linking metabolism, epigenetics and neuronal function

The circadian clock: a framework linking metabolism, epigenetics and neuronal function

Circadian rhythms and sleep—the metabolic connection

A metabolic–transcriptional network links sleep and cellular energetics in the brain

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