2024
DOI: 10.1038/s41467-024-49828-3
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Central amygdala CRF+ neurons promote heightened threat reactivity following early life adversity in mice

Camila Demaestri,
Margaux Pisciotta,
Naira Altunkeser
et al.

Abstract: Failure to appropriately predict and titrate reactivity to threat is a core feature of fear and anxiety-related disorders and is common following early life adversity (ELA). A population of neurons in the lateral central amygdala (CeAL) expressing corticotropin releasing factor (CRF) have been proposed to be key in processing threat of different intensities to mediate active fear expression. Here, we use in vivo fiber photometry to show that ELA results in sex-specific changes in the activity of CeAL CRF+ neur… Show more

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