Central ANP attenuates pressor responses to central AVP in WKY and SHR

Stepniakowski, K; Budzikowski, Adam S.; Lon, S.; Szczepañska‐Sadowska, Ewa

doi:10.1016/0361-9230(91)90076-v

Cited by 15 publications

(5 citation statements)

References 17 publications

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“…administration ( 47 ). Numerous studies found no change in BP upon central administration of ANP ( 48 – 52 ) or BNP ( 53 ). However, there are reports describing a decrease in vasopressin secretion following central ANP infusion, suggesting that ANP and vasopressin may interact to attenuate the central pressor effects of vasopressin ( 49 , 51 – 54 ).…”

Section: Natriuretic Peptidesmentioning

confidence: 99%

Natriuretic Hormones in Brain Function

Hodes

Lichtstein

2014

Front. Endocrinol.

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Natriuretic hormones (NH) include three groups of compounds: the natriuretic peptides (ANP, BNP and CNP), the gastrointestinal peptides (guanylin and uroguanylin), and endogenous cardiac steroids. These substances induce the kidney to excrete sodium and therefore participate in the regulation of sodium and water homeostasis, blood volume, and blood pressure (BP). In addition to their peripheral functions, these hormones act as neurotransmitters or neuromodulators in the brain. In this review, the established information on the biosynthesis, release and function of NH is discussed, with particular focus on their role in brain function. The available literature on the expression patterns of each of the NH and their receptors in the brain is summarized, followed by the evidence for their roles in modulating brain function. Although numerous open questions exist regarding this issue, the available data support the notion that NH participate in the central regulation of BP, neuroprotection, satiety, and various psychiatric conditions, including anxiety, addiction, and depressive disorders. In addition, the interactions between the different NH in the periphery and the brain are discussed.

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Section: Natriuretic Peptidesmentioning

confidence: 99%

Natriuretic Hormones in Brain Function

Hodes

Lichtstein

2014

Front. Endocrinol.

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“…Their hypotensive effect was demonstrated on SHR and on rats with DOXA salt hypertension. In studies on cell culture its effect by decreasing of the sympathetic neurons activity was shown [15,16]. BNP is believed to realize its effects through the NPR-A (natriuretic peptide receptor type A) receptors.…”

Section: Discussionmentioning

confidence: 99%

Comparative characteristic of the brain natriuretic peptide and angiotensin II expression index in the structure of locus coeruleus of brain stem in rats with arterial hypertension of various origins

2019

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The aim of our study was to determine the characteristics of the BNP and AT II expression in the LC structure of rat brain stem with experimental (genetically determined essential and secondary endocrine-salt) arterial hypertension and to give a comparative description of the expression pattern of these peptides in etiologically different types of arterial hypertension. Materials and methods.The study was carried out on adult 30 male rats. 20 Wistar animals were divided into two groupscontrol (10 rats) and 10 rats with simulated endocrine-salt AH (ESAH) and 10 rats of SHR line with essential AH (EAH). The expression parameters of neuropeptides, such as the content, concentration, and relative area of the immunoreactive material, were studied using an immunohistochemical method.Results. It was found that from all BNP expression parameters in the locus coeruleus structure, only relative area increased significantly in both groups. The concentration did not significantly change, and the content of immunoreactive material increased significantly only in animals with ESAH. At the same time, all parameters of angiotensin II expression increased significantly in both experimental groups. Thus, in rats with experimental arterial hypertension in the locus coeruleus structure, more pronounced changes in expression parameters are characteristic for angiotensin II, rather than for BNP. There is a discrepancy between levels of pressor angiotensin II expression and depressor BNP expression in the direction of angiotensin II expression increasing during the arterial hypertension formation. The nature and peculiarities of these neuropeptides expression in the LC structure depend on the key link of the pathogenesis of the modeled arterial hypertension. Conclusions.In rats of the control group with normal blood pressure in LC structure, AT II is more represented. The content and concentration of IRM to AT II are 2.32 and 2.19 times higher than the corresponding BNP values. Prevalence of AT II in the LC structure of the brainstem remains even when arterial hypertension is formed, regardless of its etiology. However, the etiopathogenetic mechanisms of arterial hypertension development impose their own characteristics. In EAH, the content and concentration of AT II is higher than BNP by 4.58 and 3.59 times; in ESAH -by 2.16 and 2.83 times. In the pathogenesis of essential arterial hypertension formation an important role is played by a change in the central control of blood pressure regulation. It is characterized by a significant predominance of the pressor component AT II over the depressor BNP in the brainstem LC structure.Порівняльна характеристика показників експресії мозкового натрійуретичного пептиду та ангіотензину ІІ у структурі блакитної плями стовбура мозку щурів при артеріальній гіпертензії різного ґенезу М. В. Данукало, О. В. Ганчева, Є. В. Каджарян Мета роботи -встановити особливості показників експресії мозкового натрійуретичного пептиду (BNP) та ангіотензину ІІ (АТ ІІ) у структурі блакитної плями (БП) стовбура мозку щ...

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“…Some neurotransmitters, including some of the classical ones (acetylcholine, noradrenaline, adrenaline, dopamine, serotonin, and histamine), are among them. Neuropeptides are also included, such as vasopressin, oxytocin, natriuretic peptides (NPs), corticotrophin, angiotensin, thyroxin, Y neuropeptide, leptin, endothelin, orexins, apelins, interleukin 1b, and tumor necrosis factor-α (TNF-α) as well as steroids such as mineralo- and glucocorticoids, estrogens, and testosterone [ 36 ]. Other substances involved are purines and gastric system transmitters (nitric oxide, hydrogen sulphide) [ 36 ].…”

Section: Similar Underlying Neuroendocrine Function In Psychiatricmentioning

confidence: 99%

“…The effect of neurotransmitters is usually of a short duration and can be stimulatory or inhibitory. In contrast, the effects of neuropeptides are long lasting and may contribute to the long-term modulation and restructuring of regulatory CV networks, whilst also having relevance in stress situations [ 36 ]. Since these neuroactive substances have direct effects upon the CV system and modulate this system through their actions on the CNS, they could have co-joint effects on CAD and SRD.…”

Section: Similar Underlying Neuroendocrine Function In Psychiatricmentioning

confidence: 99%

“…Besides the important cardio-renal function of NPs, they also have vasorelaxant effects and they inhibit the renin–angiotensin-aldosterone system (RAAS) and the sympathetic nervous system (SNS) [ 108 , 109 ]. Circulating ANP and vasopressin can interact to attenuate the central pressor effects of vasopressin [ 36 , 110 , 111 , 112 , 113 , 114 ], and brain natriuretic peptide (BNP) suppresses the secretion of vasopressin [ 104 ]. All of these brain regions participate in the regulation of mood and CV responses.…”

Section: Psychiatric and Cardiometabolic Mediators That Could Be Umentioning

confidence: 99%

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Epigenetic Programming of Synthesis, Release, and/or Receptor Expression of Common Mediators Participating in the Risk/Resilience for Comorbid Stress-Related Disorders and Coronary Artery Disease

Campo

Martínez-Rosas

Guarner-Lans

2018

IJMS

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Corticotrophin releasing factor, vasopressin, oxytocin, natriuretic hormones, angiotensin, neuregulins, some purinergic substances, and some cytokines contribute to the long-term modulation and restructuring of cardiovascular regulation networks and, at the same time, have relevance in situations of comorbid abnormal stress responses. The synthesis, release, and receptor expression of these mediators seem to be under epigenetic control since early stages of life, possibly underlying the comorbidity to coronary artery disease (CAD) and stress-related disorders (SRD). The exposure to environmental conditions, such as stress, during critical periods in early life may cause epigenetic programming modifying the development of pathways that lead to stable and long-lasting alterations in the functioning of these mediators during adulthood, determining the risk of or resilience to CAD and SRD. However, in contrast to genetic information, epigenetic marks may be dynamically altered throughout the lifespan. Therefore, epigenetics may be reprogrammed if the individual accepts the challenge to undertake changes in their lifestyle. Alternatively, epigenetics may remain fixed and/or even be inherited in the next generation. In this paper, we analyze some of the common neuroendocrine functions of these mediators in CAD and SRD and summarize the evidence indicating that they are under early programming to put forward the theoretical hypothesis that the comorbidity of these diseases might be epigenetically programmed and modified over the lifespan of the individual.

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Central ANP attenuates pressor responses to central AVP in WKY and SHR

Cited by 15 publications

References 17 publications

Natriuretic Hormones in Brain Function

Natriuretic Hormones in Brain Function

Comparative characteristic of the brain natriuretic peptide and angiotensin II expression index in the structure of locus coeruleus of brain stem in rats with arterial hypertension of various origins

Epigenetic Programming of Synthesis, Release, and/or Receptor Expression of Common Mediators Participating in the Risk/Resilience for Comorbid Stress-Related Disorders and Coronary Artery Disease

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