Central antinociceptive effects of non‐steroidal anti‐inflammatory drugs and paracetarmol

Evaluation of the antinociceptive and anti-inflammatory effects of Essential oil of Nepeta pogonosperma Jamzad et Assadi in rats

“…The Tail flick test is one of the most appropriate techniques to assess the acute somatosensory pain transmission by stimulating thermoreceptors in experimental animal model [25]. King et al (1997) showed that this test is sensitive to centrally acting analgesics and supraspinal systems facilitated this tail flicking response which was inhibited by a low dose of morphine [26].…”

Mechanism of Action of Nonsteroidal Anti-Inflammatory Drugs

“…This is atributed to disruption of synthesis of central prostaglandins and other modulators in the nociceptive pathway. Arguments in favor of central activity stem from studies showing the inhibitory efect of NSAIDs on N-methyl-D-aspartate (NMDA) receptor activation-induced prostaglandin expression in cerebrospinal luid [26] and antinociceptive efect of spinally administered ibuprofen [27] among others. A classic study by Hunskaar [28] showed overlapping time-efect relationship for aspirin and morphine in the irst phase of formalin-induced pain response; a feature highly indicative of central activity.…”

Effect of Rectal Paracetamol on BIS Guided Intraoperative Sedation and Postoperative Pain in Infertile Women Undergoing IVF Treatment, A Randomized Clinical Trial

“…There is insufficient information on the efficacy of paracetamol on the outcome of the IVF treatment. On the other hand the analgesic effect of preoperative paracetamol may reduce drug consumption and enhanced sedation during anesthesia [3].…”

“…Non-steroidal Anti-Inflammatory Drugs (NSAIDs), which have peripheral and central analgesic actions, have been shown to be effective analgesics when administered after surgery [3].…”