Central artery stiffness is related to cerebral oxygenation hemodynamics during executive function tasks in healthy middle-aged and older adults

Hamasaki, Ai; Akazawa, Nobuhiko; Yoshikawa, Toru; Myoenzono, Kanae; Tagawa, Kaname; Sawano, Yuriko; Nishimura, Makoto; Maeda, Seiji

doi:10.1016/j.exger.2018.10.022

Cited by 4 publications

(3 citation statements)

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“…Furthermore, pulse pressure and PWV have also been associated with cognitive decline [32]. Recently, we found that carotid arterial stiffness was correlated with executive function, which was evaluated using the Stroop interference time, similar to the present study [8]. Taniguchi et al [33] found that higher baPWV was related to cognitive decline in patients with hypertension using the mini-mental state examination.…”

Section: Discussionsupporting

confidence: 87%

“…Increases in central arterial stiffness are correlated with cerebral arterial lesions and decreased cognitive function, including memory and executive processes in older individuals [6,7]. Recently, we reported that arterial stiffness is associated with executive function in middle-aged and older adults [8]. Moreover, postmenopausal depletion of sex hormones was found to contribute to a higher risk of dementia and accelerate the increase in arterial stiffness [9].…”

Section: Introductionmentioning

confidence: 96%

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The Association between Homocysteine, Arterial Stiffness and Executive Function Middle-age and Older Women

Shindo-Hamasaki¹,

Akazawa²,

Momma³

et al. 2020

Artery Res

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 96%

The Association between Homocysteine, Arterial Stiffness and Executive Function Middle-age and Older Women

Shindo-Hamasaki¹,

Akazawa²,

Momma³

et al. 2020

Artery Res

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“…Indeed, a myriad of large cohort studies (n = 205-3207) have consistently demonstrated that large elastic artery stiffening, as measured by aortic PWV, is inversely associated with cognitive function [32,[43][44][45]. In addition to aortic PWV, aortic stiffness as assessed by carotid artery stiffening, is inversely related to cognitive function in ML/O adults [46][47][48][49]. Importantly, large elastic artery stiffening has emerged as an independent predictor of future cognitive impairment in ML/O adults [50].…”

Section: Relation Between Peripheral Vascular Function and Brain Healthmentioning

confidence: 99%

Peripheral vascular dysfunction and the aging brain

Wahl,

Clayton

2024

Aging

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Aging is the greatest non-modifiable risk factor for most diseases, including cardiovascular diseases (CVD), which remain the leading cause of mortality worldwide. Robust evidence indicates that CVD are a strong determinant for reduced brain health and all-cause dementia with advancing age. CVD are also closely linked with peripheral and cerebral vascular dysfunction, common contributors to the development and progression of all types of dementia, that are largely driven by excessive levels of oxidative stress (e.g., reactive oxygen species [ROS]). Emerging evidence suggests that several fundamental aging mechanisms (e.g., "hallmarks" of aging), including chronic lowgrade inflammation, mitochondrial dysfunction, cellular senescence and deregulated nutrient sensing contribute to excessive ROS production and are common to both peripheral and cerebral vascular dysfunction. Therefore, targeting these mechanisms to reduce ROS-related oxidative stress and improve peripheral and/or cerebral vascular function may be a promising strategy to reduce dementia risk with aging. Investigating how certain lifestyle strategies (e.g., aerobic exercise and diet modulation) and/or select pharmacological agents (natural and synthetic) intersect with aging "hallmarks" to promote peripheral and/or cerebral vascular health represent a viable option for reducing dementia risk with aging. Therefore, the primary purpose of this review is to explore mechanistic links among peripheral vascular dysfunction, cerebral vascular dysfunction, and reduced brain health with aging. Such insight and assessments of non-invasive measures of peripheral and cerebral vascular health with aging might provide a new approach for assessing dementia risk in older adults.

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Carotid Artery Stiffness is Associated With Cognitive Performance in Former Smokers With and Without Chronic Obstructive Pulmonary Disease

Hoth

Moreau

Weinberger

et al. 2020

JAHA

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Background Heavy smokers perform worse on neuropsychological assessment than age‐matched peers. However, traditional pulmonary measures of airflow limitation and hypoxemia explain only a modest amount of variance in cognition. The current objective was to determine whether carotid artery stiffness is associated with cognition in former smokers beyond the effects of amount of smoking and pulmonary function. Methods and Results Eighty‐four former smokers including individuals across a spectrum of airflow limitation severity were included: 30 without chronic obstructive pulmonary disease (Global Initiative for Chronic Obstructive Lung Disease [GOLD] 0 with normal spirometry and lung computed tomography), 31 with mild‐moderate chronic obstructive pulmonary disease ( GOLD 1–2), and 23 with severe‐very severe chronic obstructive pulmonary disease ( GOLD 3–4). Participants completed questionnaires, spirometry, carotid ultrasonography, and neuropsychological testing. Multiple linear regression was used to determine whether carotid artery stiffness is associated with neuropsychological performance in 4 cognitive domains after adjusting for age, sex, pack‐years of smoking, estimated premorbid intellectual functioning, and airflow limitation. Higher carotid artery β‐stiffness index was associated with reduced executive functioning‐processing speed in the fully adjusted model (β=−0.49, SE =0.14; P =0.001). Lower premorbid intellectual function, male sex, and presence of airflow limitation ( GOLD 1 or 2 and GOLD 3 or 4) were also associated with worse executive functioning‐processing speed. β‐Stiffness index was not significantly associated with performance in other cognitive domains. Conclusions Carotid artery stiffness is associated with worse performance on executive functioning‐processing speed in former smokers beyond the effects of aging, amount of past smoking, severity of airflow limitation, and hypoxemia. Future research should examine whether carotid stiffness can be used to identify former smokers at risk for subsequent cognitive impairment.

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Central artery stiffness is related to cerebral oxygenation hemodynamics during executive function tasks in healthy middle-aged and older adults

Cited by 4 publications

References 46 publications

The Association between Homocysteine, Arterial Stiffness and Executive Function Middle-age and Older Women

The Association between Homocysteine, Arterial Stiffness and Executive Function Middle-age and Older Women

Peripheral vascular dysfunction and the aging brain

Carotid Artery Stiffness is Associated With Cognitive Performance in Former Smokers With and Without Chronic Obstructive Pulmonary Disease

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