1982
DOI: 10.1016/0031-9384(82)90334-1
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Central, as well as peripheral naloxone administration suppresses feeding in food-deprived sprague-dawley and genetically obese (Zucker) rats

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Cited by 39 publications
(10 citation statements)
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“…A similar pattern was also seen when rats were given free access to food pellets. This finding may seem to contradict previous reports showing increased sensitivity to opioid antagonists in obese Zucker rats ( Thornhill et al 1982;Mclaughlin and Baile 1984;Mclaughlin et al 1986). However, direct comparisons are problematic because of a number of important differences in experimental parameters between the present and past studies which include the sex of animals, duration of food intake measures and types of food presented during food intake tests.…”
Section: Discussioncontrasting
confidence: 82%
See 1 more Smart Citation
“…A similar pattern was also seen when rats were given free access to food pellets. This finding may seem to contradict previous reports showing increased sensitivity to opioid antagonists in obese Zucker rats ( Thornhill et al 1982;Mclaughlin and Baile 1984;Mclaughlin et al 1986). However, direct comparisons are problematic because of a number of important differences in experimental parameters between the present and past studies which include the sex of animals, duration of food intake measures and types of food presented during food intake tests.…”
Section: Discussioncontrasting
confidence: 82%
“…Notably, opioid agonists and antagonists have been effective in suppressing food intake when infused into hypothalamic sites (Gosnell et al 1986;Koch et al 1995), implicated in the etiology of experimental obesity syndromes (Bray and York 1979). Early evidence indicated that obese Zucker rats may be more sensitive to the anorectic effects of opioid antagonists when compared to their lean litter mates (Thornhill et al 1982;Mclaughlin and Baile 1984;Mclaughlin et al 1986), suggesting that the opioid system may mediate hyperphagia in obese Zucker rats. The behavioral mechanisms by which opioid antagonists affect food intake in obese rats are unclear, and the second aim of our studies was to investigate the effect of the opioid antagonist naloxone on motivation for food.…”
Section: Introductionmentioning
confidence: 97%
“…Systemic administration of naloxone has been shown to suppress food and water intakes both in ad-lib fed (BRANDS et al, 1979) and in food and water deprived animals (BRANDS et a!., 1979;CAREY et a!., 1981;THORNHILL et a!.,1982). Thus the endogenous opioid system may have a strong modulating effect on feeding and drinking activity.…”
Section: Discussionmentioning
confidence: 99%
“…Elevated levels of the opioid peptide b-endorphin have been found in the pituitary of both genetically obese fa/fa rats and ob/ob mice (Margules, Moisset, Lewis, Shibuya, & Pert, 1978), and food intake has been shown to be reduced in response to naloxone. Preclinical studies indicate that opioid antagonists decrease intake of food and water (Beczkowska, Bowen, & Bodnar, 1992;Brown & Holtzman, 1981;Thornhill, Taylor, Marshall, & Parent, 1982) as well as sweet solutions and high-fat foods (Beczkowska et al, 1992;Islam & Bodnar, 1990). Although studies in human subjects indicate that naltrexone alters eating behavior and reduces intake of food and caloric intake, the influence of naltrexone on weight in normal and obese patients remains equivocal (see de Zwaan & Mitchell, 1992, for review).…”
Section: Introductionmentioning
confidence: 97%