Central auditory processing during chronic tinnitus as indexed by topographical maps of the mismatch negativity obtained with the multi-feature paradigm

Mahmoudian, Saeid; Farhadi, Mohammad; Najafi-Koopaie, Mojtaba; Darestani-Farahani, Ehsan; Mohebbi, Mehrnaz; Dengler, Reinhard; Esser, Karl‐Heinz; Salamat, Behrouz; Danesh, Ali A.; Lenarz, Thomas

doi:10.1016/j.brainres.2013.06.019

Cited by 46 publications

(47 citation statements)

References 45 publications

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“…Although many studies using MMN in the evaluation of various pathologies 31,32 and symptoms such as tinnitus 33 report differences in MMN amplitudes, our findings showed no statistically significant differences in MMN amplitudes between the two groups. As withother assessments of the auditory system by means of evoked potentials where the amplitudes of the waves do not have associated standardized values (short latency and P300 for example), the findings of this research suggest that the wave amplitude in MMN is not a useful measure for the evaluation of tinnitus, at least within the context of the evaluation methods and equipment used.…”

contrasting

confidence: 53%

The mismatch negativity test in ears with and without tinnitus-a path to the objectification of tinnitus

Holdefer¹,

Oliveira²,

Venosa³

2013

The International Tinnitus Journal

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contrasting

confidence: 53%

The mismatch negativity test in ears with and without tinnitus-a path to the objectification of tinnitus

Holdefer¹,

Oliveira²,

Venosa³

2013

The International Tinnitus Journal

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“…Thus, it comes as no surprise that several, partly conflicting, neurobiological models exist that sketch the complex interplay between multiple cortical and subcortical human brain areas which may mediate the subjective experience of chronic tinnitus [6, 10–14]. These models agree in that they describe tinnitus as the unwanted result of an imbalance between inhibition and excitation of thalamocortical circuits [15]. According to this view, peripheral hearing loss caused by damage to hair cells in the inner ear results in deficient auditory information transfer to the auditory brain.…”

Section: Introductionmentioning

confidence: 99%

Disentangling Tinnitus Distress and Tinnitus Presence by Means of EEG Power Analysis

et al. 2014

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The present study investigated 24 individuals suffering from chronic tinnitus (TI) and 24 nonaffected controls (CO). We recorded resting-state EEG and collected psychometric data to obtain information about how chronic tinnitus experience affects the cognitive and emotional state of TI. The study was meant to disentangle TI with high distress from those who suffer less from persistent tinnitus based on both neurophysiological and behavioral data. A principal component analysis of psychometric data uncovers two distinct independent dimensions characterizing the individual tinnitus experience. These independent states are distress and presence, the latter is described as the perceived intensity of sound experience that increases with tinnitus duration devoid of any considerable emotional burden. Neuroplastic changes correlate with the two independent components. TI with high distress display increased EEG activity in the oscillatory range around 25 Hz (upper β-band) that agglomerates over frontal recording sites. TI with high presence show enhanced EEG signal strength in the δ-, α-, and lower γ-bands (30–40 Hz) over bilateral temporal and left perisylvian electrodes. Based on these differential patterns we suggest that the two dimensions, namely, distress and presence, should be considered as independent dimensions of chronic subjective tinnitus.

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“…Mahmoudian et al [2013] reported significantly smaller silent-gap MMN in patients with tinnitus as compared to that in the normal controls. We believe that in the present study, the difficulty in disengaging could have possibly contributed to the different results.…”

Section: Discussionmentioning

confidence: 99%

“…Previous MMN studies, in which stimuli in the nontinnitus frequency range were applied, reported potential deficits in the automated central auditory processing mechanisms in patients with decompensated tinnitus [Weisz et al, 2004;Mahmoudian et al, 2013;Yang et al, 2013]. The present study employed auditory signals within the tinnitus frequency range, for further characterization of attentional bias in patients with decompensated tinnitus.…”

Section: Introductionmentioning

confidence: 99%

“…For example, a study using the Stroop test conducted by Stevens et al [2007] found significantly worse behavioral performance (indexed by longer response time and lower accuracy) in patients with decompensated tinnitus, as compared to that in normal controls. Event-related potential (ERP) studies have also indicated that tinnitus patients suffer from a cognitive processing disorder at an early selective attention stage [Jacobson et al, 1996;Walpurger et al, 2003;Delb et al, 2008] or even at the preattention stage [Weisz et al, 2004;Mahmoudian et al, 2013;Yang et al, 2013].…”

Section: Introductionmentioning

confidence: 99%

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Attentional Bias in Patients with Decompensated Tinnitus: Prima Facie Evidence from Event-Related Potentials

Zeng

et al. 2016

Audiol Neurotol

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Tinnitus refers to the auditory perception of sound in the absence of external sound or electric stimuli. The influence of tinnitus on cognitive processing is at the cutting edge of ongoing tinnitus research. In this study, we adopted an objective indicator of attentional processing, i.e. the mismatch negativity (MMN), to assess the attentional bias in patients with decompensated tinnitus. Three kinds of pure tones, D₁ (8,000 Hz), S (8,500 Hz) and D₂ (9,000 Hz), were used to induce event-related potentials (ERPs) in the normal ear. Employing the oddball paradigm, the task was divided into two blocks in which D₁ and D₂ were set as deviation stimuli, respectively. Only D₂ induced a significant MMN in the tinnitus group, while neither D₁ nor D₂ was able to induce MMN in the control group. In addition, the ERPs in the left hemisphere, which were recorded within the time window of 90-150 ms (ERP_{90-150 ms}), were significantly higher than those in the right hemisphere in the tinnitus group, while no significant difference was observed in the control group. Lastly, the amplitude of ERP_{90-150 ms} in the tinnitus group was significantly higher than that in the control group. These findings suggest that patients with decompensated tinnitus showed automatic processing of acoustic stimuli, thereby indicating that these patients allocated more cognitive resources to acoustic stimulus processing. We suggest that the difficulty in disengaging or facilitated attention of patients might underlie this phenomenon. The limitations of the current study are discussed.

show abstract

Central auditory processing during chronic tinnitus as indexed by topographical maps of the mismatch negativity obtained with the multi-feature paradigm

Cited by 46 publications

References 45 publications

The mismatch negativity test in ears with and without tinnitus-a path to the objectification of tinnitus

The mismatch negativity test in ears with and without tinnitus-a path to the objectification of tinnitus

Disentangling Tinnitus Distress and Tinnitus Presence by Means of EEG Power Analysis

Attentional Bias in Patients with Decompensated Tinnitus: Prima Facie Evidence from Event-Related Potentials

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