Central Beneficial Effects of Trimetazidine on Psychomotor Performance in Normal Healthy Volunteers

Al-Kuraishy, Hayder M; Al-Gareeb, Ali I

doi:10.4103/2277-9175.190994

Cited by 16 publications

(10 citation statements)

References 20 publications

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“…Thus, a placebo may cause upgrading or deterioration of human cognitive function depending on specific expectations. Therefore, the effect of placebo may be revealed on human cognitive functions and reaction time during psychomotor performance, vigilance, and working memory testing depending on stereotype stimulations ( Al-Kuraishy, Al-Gareeb, & Ashor, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

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Citicoline Improves Human Vigilance and Visual Working Memory: The Role of Neuronal Activation and Oxidative Stress

Al-Kuraishy

Al-Gareeb

2020

Basic Clin. Neurosci. J.

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Introduction: Psychomotor performance task is used to assess the arousal and cognitive functions of the central nervous system. Alternatively, human visual working memory reflects the capability of the individual’s short-term memory. Psycho-mental stimuli are linked to the stimulation of Malondialdehyde (MDA) formations. Citicoline is a nootropic nucleotide agent with a favorable effect on the augmentation of human memory and cognitive function. Thus, the purpose of this study was to determine the effect of citicoline on human vigilance, visual working memory, and oxidative stress using healthy volunteers. Methods: 40 healthy volunteers were enrolled and divided into two groups: group A: 20 volunteers received 500mg/day starch capsule for two weeks and group B: 20 volunteers received 500mg/day citicoline capsule for two weeks. Human vigilance, visual working memory, and oxidative stress markers of each volunteer were assessed before and after citicoline and placebo intake. The obtained data were analyzed by SPSS regarding P<0.05 as statistically significant. Results: Placebo had no significant effect on human vigilance and visual working memory after two weeks of therapy (P>0.05), whereas citicoline improved most variables of psychomotor performances and working memory (P<0.01). Placebo significantly increased serum MDA levels from 19.44±2.11 to 29.66±3.28 nmol/mL (P=0.0001), while citicoline significantly decreased MDA serum levels from 19.11±2.66 to 15.63±1.33 nmol/mL (P=0.0001). Conclusion: Citicoline improves human psychomotor vigilance, arousal, and visual working memory with significant amelioration of oxidative stress compared with placebo.

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Section: Discussionmentioning

confidence: 99%

“…The range of fusion-flicker frequency was from zero to 60 Hz. Good values for CFFA should be more than 30 Hz and less than 30Hz for CFFD (CFFF= CFFA+CFFD/2) ( Al-kuraishy & Al-Gareeb, 2017 ; Angeli, Veres, Nagy & Schneider 2016 ).…”

Section: Methodsmentioning

confidence: 99%

Citicoline Improves Human Vigilance and Visual Working Memory: The Role of Neuronal Activation and Oxidative Stress

Al-Kuraishy

Al-Gareeb

2020

Basic Clin. Neurosci. J.

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“…Mice with orexin knockout are subjected to narcolepsy and excessive daytime sleepiness. [ 7 ] Alizamini et al . 's study showed that central administration of orexin leads to stimulation of locomotion, psychomotor performance, body temperature, and energy expenditure.…”

Section: Introductionmentioning

confidence: 99%

Involvement of orexinergic system in psychiatric and neurodegenerative disorders: A scoping review

et al. 2020

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Orexin is a neuropeptide secreted from lateral hypothalamus and pre-frontal cortex concerned in the wakefulness and excitement. This study aimed to review the possible neurobiological effect of orexin. A diversity of search strategies was adopted and assumed which included electronic database searches of Medline and PubMed using MeSH terms, keywords, and title words during the search. Orexin plays a vital role in activation of learning, memory acquisition, and consolidation through activation of monoaminergic system, which affect cognitive flexibility and cognitive function. Orexin stimulates adrenocorticotropin and corticosteroid secretions via activation of central corticotropin-releasing hormone. Cerebrospinal fluid (CSF) and serum orexin serum levels are reduced in depression, schizophrenia, and narcolepsy. However, high orexin serum levels are revealed in drug addictions. Regarding neurodegenerative brain diseases, CSF and serum orexin serum levels are reduced Parkinson disease, Alzheimer dementia, Huntington's disease, amyotrphic lateral sclerosis, and multiple sclerosis. Orexin antagonist leads to significant reduction of sympathetic over-activity during withdrawal syndrome. As well, orexin antagonist improves sleep pattern. Orexinergic system is involved in the different psychiatric and neurological disorders; therefore, targeting of this system could be possible novel pathway in the management of these disorders. In addition, measurement of CSF and serum orexin levels might predict the relapse and withdrawal of addict patients.

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“…In the RCT conducted by Al-Kuraishy et al, the authors showed that trimetazidine enhances psychomotor parameters in non-athletic volunteers. This work was published in 2017, three years after the WADA trimetazidine ban (51). Vitale et al demonstrated that trimetazidine improves exercise performance in patients with pe-ripheral arterial disease, but they did not examine healthy volunteers or athletes (52).…”

Section: Trimetazidinementioning

confidence: 99%

The Inclusion in WADA Prohibited List Is Not Always Supported by Scientific Evidence: A Narrative Review

Bezuglov

Talibov

Butovskiy³

et al. 2021

Asian J Sports Med

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Context: Our goal was to review the current literature regarding the ability of substances that have recently been included in the WADA prohibited list (i.e., meldonium, trimetazidine, xenon, and cobalt) or in the monitoring program (i.e., ecdysterone and bemethyl) to enhance performance in athletes or cause adverse effects. Evidence Acquisition: To find out which studies led to the prohibition of the substances mentioned, we searched the PubMed database using keywords including the substances’ or methods’ names, as well as phrases related to various aspects of sports activities and health assessments of athletes. Results: The results obtained during our systematic literature search clearly indicate that there is a lack of scientific evidence supporting the impact of several substances prohibited by WADA (i.e., meldonium, trimetazidine, xenon, and cobalt) on athletic performance or on health in athletes. Conclusions: There is insufficient evidence that the previously mentioned substances have any performance enhancing potential. If left on the list, meldonium may be classified as a “specified substance” because of its wide availability and due to the fact that this drug that can be easily bought over the counter without a prescription.

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Central Beneficial Effects of Trimetazidine on Psychomotor Performance in Normal Healthy Volunteers

Cited by 16 publications

References 20 publications

Citicoline Improves Human Vigilance and Visual Working Memory: The Role of Neuronal Activation and Oxidative Stress

Citicoline Improves Human Vigilance and Visual Working Memory: The Role of Neuronal Activation and Oxidative Stress

Involvement of orexinergic system in psychiatric and neurodegenerative disorders: A scoping review

The Inclusion in WADA Prohibited List Is Not Always Supported by Scientific Evidence: A Narrative Review

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