Central breathing abnormalities in children with trisomy 21: Effect of age, sex, and concomitant OSA

Naime, Samira; Weiss, Miriam; Lew, Jenny; Aziz, Julia; Pan, Qi; Allen, Michelle; Xuchen, Xilei; Weinstock, Jered; Niño, Gustavo

doi:10.1002/ppul.25157

Cited by 9 publications

(27 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There were two studies that evaluated the relationship between age and the central apnoea index (CAI) [22,30]. CHAMSEDDIN et al [22] did not find a difference between older and younger children when comparing mean CAI.…”

Section: Agementioning

confidence: 99%

“…CHAMSEDDIN et al [22] did not find a difference between older and younger children when comparing mean CAI. NAIME et al [30] reported that a higher percentage of children aged <2 years had a diagnosis of CSA, when compared to children in the 3-10 years and >10 years age groups.…”

Section: Agementioning

confidence: 99%

“…ANAND, 2021 [16] AUSTENG, 2014 [17] BANJAR, 2013 [18] BASIL, 2016 [19] BRESLIN, 2014 [20] BROOKS, 2015 [21] CHAMSEDDIN, 2019 [22] DURHAN, 2019 [23] DYKEN, 2003 [9] ELSHARKAWI, 2017 [24] FRIEDMAN, 2018 [25] JAYARATNE, 2017 [26] LEE, 2020 [27] MARIS, 2016 [28] MARIS, 2016 [29] DE MIGUEL-DÍEZ, 2003 [4] NAIME, 2021 [30] NEHME, 2017 [8] POSADA, 2019 [31] RICHARD, 2020 [32] ROSEN, 2020 [33] SHIRES, 2010 [34] SKOTKO, 2017 [35] WATERS, 2020 [36] Bias…”

Section: Agementioning

confidence: 99%

“…CHAMSEDDIN [22], SKOTKO [35] # (d= −0.74) ROSEN [33], NEHME [8] (OR=1.14) MARIS [29] (r= −0.199), WATERS [36] (Chi-squared=12.87) NEHME [8], MARIS [29] NAIME [30] CHAMSEDDIN [22] RICHARD [32] Male sex DE MIGUEL-DÍEZ [4] (OR=3.32)…”

Section: No Associationmentioning

confidence: 99%

“…BROOKS [21] SKOTKO [35], SHIRES [34], AUSTENG [17], BRESLIN [20] (OR=0.22), LEE [27] Maris [29], ROSEN [33] NAIME [30] # NAIME [30] #…”

Section: No Associationmentioning

confidence: 99%

See 4 more Smart Citations

Predictors of sleep disordered breathing in children with Down syndrome: a systematic review and meta-analysis

Hanna

Blinder

et al. 2022

Eur Respir Rev

View full text Add to dashboard Cite

Children with Down syndrome are at increased risk of sleep disordered breathing (SDB). SDB is associated with significant morbidity including neurocognitive impairment, cardiometabolic disease and systemic inflammation. The identification of clinical markers that may predict SDB is critical in facilitating early diagnosis and treatment, and ultimately, preventing morbidity. The objective of this systematic review was to identify predictors of SDB in patients with Down syndrome. A search was conducted using MEDLINE, Embase, the Cochrane Central Register of Controlled Trials and the Cumulative Index to Nursing and Allied Health Literature. A meta-analysis was performed according to the Meta-analyses of Observational Studies in Epidemiology checklist. Our review of the literature identified inconsistent associations between a variety of variables and SDB in children with Down syndrome, although the quality of evidence was poor. Meta-analysis of age and sex identified that children with OSA were older than those without OSA, and there was a similar risk of OSA in males and females, although risk favoured males. Currently, the American Academy of Pediatrics guidelines recommend that children with Down syndrome undergo polysomnography by the age of 4 years. Our review supports the recommendation for routine screening of children with Down syndrome. However, results from our meta-analysis suggest a need for longitudinal screening to diagnose children who may develop SDB as they get older.

show abstract

Section: Agementioning

confidence: 99%

Section: Agementioning

confidence: 99%

Section: Agementioning

confidence: 99%

Section: No Associationmentioning

confidence: 99%

“…BROOKS [21] SKOTKO [35], SHIRES [34], AUSTENG [17], BRESLIN [20] (OR=0.22), LEE [27] Maris [29], ROSEN [33] NAIME [30] # NAIME [30] #…”

Section: No Associationmentioning

confidence: 99%

See 3 more Smart Citations

Predictors of sleep disordered breathing in children with Down syndrome: a systematic review and meta-analysis

Hanna

Blinder

et al. 2022

Eur Respir Rev

View full text Add to dashboard Cite

show abstract

Pediatric pulmonary year in review 2021: Sleep medicine

Okorie

Afolabi‐Brown

Tapia

2022

Pediatric Pulmonology

View full text Add to dashboard Cite

Pediatric pulmonology publishes original research, review articles, and case reports on a wide variety of pediatric respiratory disorders. In this article, we summarized the past year's publications in sleep medicine and reviewed selected literature from other journals in this field. We focused on original research articles exploring aspects of sleep‐disordered breathing in patients with underlying conditions such as cystic fibrosis, asthma, and sickle cell disease. We also explored sleep‐disordered breathing risk factors, monitoring, diagnosis, and treatment; and included recent recommendations for drug‐induced sleep endoscopy and ways to monitor and improve PAP adherence remotely.

show abstract

Developmental changes in obstructive sleep apnea and sleep architecture in Down syndrome

Kahanowitch

Aguilar

Weiss

et al. 2023

Pediatric Pulmonology

Self Cite

View full text Add to dashboard Cite

Background Down syndrome (DS, also known as Trisomy 21) is a condition associated with abnormal neurodevelopment and a higher risk for sleep apnea. Our study sought to better understand and characterize the age‐related developmental differences in sleep architecture and obstructive sleep apnea (OSA) severity in children with DS compared to euploid individuals. Methods Retrospective review of polysomnograms in over 4151 infants, children, and adolescents in the pediatric sleep center at Children's National Hospital in Washington D.C. (0–18 years) including 218 individuals with DS. Results The primary findings of our study are that: (1) severe OSA (obstructive apnea‐hypopnea index ≥ 10/h) was more prevalent in the DS group (euploid 18% vs. DS 34%, p < 0.001) with the highest OSA severity being present in young children (<3 years old) and adolescents (>10 years old), (2) abnormalities in sleep architecture in children with DS were characterized by a prolonged rapid‐eye movement (REM) sleep onset latency (SOL) (euploid 119 min vs. DS 144 min, p < 0.001) and greater arousal indexes (euploid 10.7/h vs. DS 12.2/h, p < 0.001), (3) developmental changes in the amount of REM sleep or slow wave sleep were not different in DS individuals relative to euploid children, (4) multivariate analyses showed that OSA and REM sleep latency differences between DS and euploid individuals were still present after adjusting by age, biological sex, and body mass index. Conclusion Severe OSA is highly prevalent in children with DS and follows an age‐dependent “U” distribution with peaks in newborns/infants and children >10 years of age. Children with DS also have disturbances in sleep architecture characterized by a longer REM SOL and elevated arousal indexes. As sleep cycle generation and continuity play crucial roles in neuroplasticity and cognitive development, these findings offer clinically relevant insights to guide anticipatory guidance for infants, children, and adolescents with DS.

show abstract

Central breathing abnormalities in children with trisomy 21: Effect of age, sex, and concomitant OSA

Cited by 9 publications

References 28 publications

Predictors of sleep disordered breathing in children with Down syndrome: a systematic review and meta-analysis

Predictors of sleep disordered breathing in children with Down syndrome: a systematic review and meta-analysis

Pediatric pulmonary year in review 2021: Sleep medicine

Developmental changes in obstructive sleep apnea and sleep architecture in Down syndrome

Contact Info

Product

Resources

About