Central cholinergic activation induces greater thermoregulatory and cardiovascular responses in spontaneously hypertensive than in normotensive rats

Control of Body Temperature during Physical Exercise

“…7 This mechanism can be activated by central cholinergic stimulation via modulation of arterial baroreceptors by increasing the blood flow of the rat´s tail. 8,9 Additionally, vasodilation of the skin of the feet, the evaporation of saliva spread onto the body surface, the evaporation of water from the respiratory tract and even voluntary urination associated with urine spreading activity may also contribute to the total heat dissipation. 10…”

“…In SHR rats, for example, decreased baroreceptor sensitivity, sympathetic hyperactivity, which leads to increased peripheral resistance, and endothelial dysfunction may impair cutaneous vasodilation of the tail and, consequently, heat dissipation. 7,9…”