Central composite design–based optimization, fabrication, and pharmacodynamic assessment of sulfasalazine-loaded lipoidal nanoparticle-based hydrogel for the management of rheumatoid arthritis

Mishra, Ritu; Jain, Nidhi; Kaul, Shreya; Nagaich, Upendra

doi:10.1007/s13346-022-01260-0

Cited by 8 publications

(4 citation statements)

References 40 publications

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“…It is more simplified than orthogonal test and more comprehensive than uniform design ( Fang et al, 2021 ). It has fewer test times and higher test accuracy, and is suitable for multi-factor and multi-level test ( Mishra et al, 2023 ). Most importantly, it can also predict the results of unperformed tests ( Liu et al, 2023a , Liu et al, 2023b ).…”

Section: Discussionmentioning

confidence: 99%

Preparing a novel baicalin-loaded microemulsion-based gel for transdermal delivery and testing its anti-gout effect

Wang,

Liu,

et al. 2024

Saudi Pharmaceutical Journal

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Section: Discussionmentioning

confidence: 99%

Preparing a novel baicalin-loaded microemulsion-based gel for transdermal delivery and testing its anti-gout effect

Wang,

Liu,

et al. 2024

Saudi Pharmaceutical Journal

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“…Improved topical delivery systems have also been developed for psoriasis and rheumatoid arthritis treatments. A composite hydrogel made of Carbopol ® , incorporating tacrolimusloaded polymeric nanocarriers has shown enhanced skin delivery and treatment efficacy in psoriasis models [60], while a sulfasalazine-loaded solid lipid nanoparticle-based hydrogel optimized for rheumatoid arthritis management significantly reduces paw thickness and pro-inflammatory cytokines [88]. For osteoarthritis, a colchicine mesoporous silica nanoparticles/hydrogel composite applied to cotton patches has enhanced drug flux and permeation, with its therapeutic efficacy validated in rat models [64].…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

Hydrogel Composites for Multifunctional Biomedical Applications

Omidian,

Akhzarmehr,

Dey Chowdhury

2024

J. Compos. Sci.

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Hydrogel composites are pivotal in biomedical research, showing promise across various applications. This review aims to thoroughly examine their significance and versatile roles in regenerative medicine, tissue engineering, and drug delivery systems. Key areas of investigation include integrating growth factor delivery systems, overcoming structural limitations in tissue engineering, exploring innovations in clinical applications, and addressing challenges in achieving bioactivity and biomechanical compatibility. Furthermore, the review will discuss controlled release mechanisms for drug delivery, advancements in biocompatibility and mechanical stability, recent progress in tissue regeneration and wound healing, and future prospects such as smart hydrogels, personalized treatments, and integration with wearable technology. Ultimately, the goal is to provide a comprehensive understanding of how hydrogel composites impact biomedical research and clinical practice.

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“…The Central Composite design comprises a thorough factorial layout involving central points and a sequence of axial points, facilitating the computation of curvature. The impact of independent factors such as Drug lipid ratio (A) and Gelucire 44/14 concentration (B) on dependent factors like particle size (Y1) and entrapment e ciency (Y2) was assessed [27]. Thirteen formulations were prepared, and their effects on the responses were evaluated.…”

Section: Optimization Of Aspm-loaded Nlcs Using the Central Composite...mentioning

confidence: 99%

Tailoring Nanostructured Lipid Carriers for Efficient Delivery of Asenapine Maleate in Antipsychotic Treatment

Rao,

Jamadar

2024

Preprint

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Asenapine Maleate (ASPM), is the atypical antipsychotic agent used for treating various psychological disorders such as schizophrenia and acute mania associated with bipolar disorder. However, the drug's therapeutic potential is intricately linked to its solubility, bioavailability, stability, and ability to be delivered specifically to the central nervous system. The aim of the study was to design, develop, and optimize Nanostructured Lipid Carriers (NLCs) encapsulating Asenapine maleate to improve the therapeutic efficacy. The development utilized a systematic approach; various formulation parameters such as lipid composition, surfactant concentration, and entrapment efficiency were meticulously optimized by employing quality-by-design principles. The optimized ASPM-loaded NLCs demonstrated a particle size of 97.6 ± 2.48 nm, zeta potential of −20mV, and entrapment efficiency of 96.74%, respectively. ASPM-loaded NLC showed initially rapid release (20%) accompanied by sustained release (75%) over 24 hr with 22-fold improvement in oral bioavailability with significantly reduced locomotor count induced by L-DOPA-carbidopa in comparison with the pure drug in Sprague-Dawley rats. Furthermore, in-vitro and in-vivo results underscored the enhanced permeability through the blood-brain barrier with superior pharmacokinetics for the NLC. Collectively, this research elucidates the potential of optimized NLCs as robust drug delivery system for asenapine maleate, offering a promising avenue for advancing therapeutic results in the management of psychosis.

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Central composite design–based optimization, fabrication, and pharmacodynamic assessment of sulfasalazine-loaded lipoidal nanoparticle-based hydrogel for the management of rheumatoid arthritis

Cited by 8 publications

References 40 publications

Preparing a novel baicalin-loaded microemulsion-based gel for transdermal delivery and testing its anti-gout effect

Preparing a novel baicalin-loaded microemulsion-based gel for transdermal delivery and testing its anti-gout effect

Hydrogel Composites for Multifunctional Biomedical Applications

Tailoring Nanostructured Lipid Carriers for Efficient Delivery of Asenapine Maleate in Antipsychotic Treatment

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