Central Corneal Endothelial Cell Counts in Children

Hiles, David A.; Biglan, Albert W.; Fetherolf, Edward

doi:10.1016/s0146-2776(79)80078-6

Cited by 40 publications

(9 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In adults, a trend towards stabilisation of losses to physiologically normal levels has been reported at 3 years postoperatively18; however, long-term data on the effect of these lenses on the corneal endothelium in adults and children are awaited. A higher natural rate of endothelial cell losses has also been reported in children compared to the adult population, as high as 500 cells/mm 2 per year in some studies 19 20. We have assumed that, in the long term, endothelial cell failure may occur in a proportion of these patients, and all patients in this study were counselled about this risk.…”

Section: Discussionmentioning

confidence: 85%

Artisan iris-claw lenses for the correction of aphakia in children following lensectomy for ectopia lentis

Cleary

Lanigan²,

O'Keeffe³

2011

Br J Ophthalmol

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 85%

Artisan iris-claw lenses for the correction of aphakia in children following lensectomy for ectopia lentis

Cleary

Lanigan²,

O'Keeffe³

2011

Br J Ophthalmol

View full text Add to dashboard Cite

show abstract

“…No significant differences in cell density were found between the right or left eyes or between male or female subjects of similar subjects (Laule et al 1978). Present data indicates that corneal cell density in a normal eye remains unchanged from the ages of five to twenty (Hiles, Biglan, and Fetherolf 1979). Therefore, changes in the corneal endothelium, can be thought of or described as a function of age (Laing et al 1976).…”

Section: Introductionmentioning

confidence: 58%

Gene-Set Enrichment Analysis of Differentially Expressed Genes in the Transcriptome of the Human Corneal Endothelium in Association with Age Effecta

Saha¹,

Barmon²

2018

Preprint

View full text Add to dashboard Cite

The eyes are the sense organs through we view the world around us, and the cornea is the transparent layer which covers the outer, visible part of the eye. It is known that the gene expression of corneal endothelium depends on age. And the expressed genes of the endothelium of cornea for pediatric samples is different than that of the adult samples. The purpose or objective of this study was to characterize human corneal endothelial cell (HCEnC) gene expression and differential gene expression and to detect the expressed genes mapped to chromosomal loci associated with some corneal endothelial dystrophies. Both upregulated and downregulated genes were analyzed. For this purpose, total RNA was isolated from ex vivo corneal endothelium taken from six pediatric and five adult corneas. The complementary DNA was hybridized to the Affymetrix GeneChip 1.1 ST array. The data analysis was performed using the Enrichr software for both upregulated and downregulated genes. These are described in more detail in the results and discussion section. This study uses bioinformatics tools to identify and analyse gene sets present in the transcriptome of the corneal endothelium, and tries to find out and observe the relation of the aging effect on the corneal endothelium gene expression. The human subjects had participated voluntarily and informed consent was obtained from all before carrying out any testing procedure. Proper guidelines from the hospital ethical committee were also followed and no harmful chemicals were used on the participants. This study simply aims to raise some awareness of the given topic among the local people so that they are better able to take informed choices about their health in the near future, and also so that they seek medical help when necessary and have no inhibitions in doing so.

show abstract

“…During one's lifetime the density of CE cells can drop from an average of 5500 cells/mm 2 at birth to as low as 400-700 cell/mm 2 without diminishing corneal transparency [38, 39]. CE cells do not undergo mitosis in vivo [40].…”

Section: Sac Expression In the Eyementioning

confidence: 99%

Soluble adenylyl cyclase in the eye

Lee

Marmorstein

2014

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

View full text Add to dashboard Cite

Adenylyl cyclases (AC) are a family of enzymes which convert ATP to cAMP an essential intermediate in many signal transduction pathways. Of the 10 AC genes in man, 9 fall into the category of transmembrane ACs (tmAC), which associate with G-protein coupled receptors (GPCRs) and are activated by forskolin. The 10th AC, termed soluble AC (sAC) is neither activated by forskolin nor does it interact with GPCRs. Rather, sAC can be found in many compartments within the cell and is activated by bicarbonate. As such, sAC is considered a major sensor of bicarbonate in many tissues. The pathways involving sAC vary in different tissues and organ systems, and are as diverse as facilitating sperm capacitation and regulating pressure in the eye. The role of sAC in the eye has only recently begun to receive significant attention. Here we summarize what is known about the roles of sAC in the eye.

show abstract

Central Corneal Endothelial Cell Counts in Children

Cited by 40 publications

References 18 publications

Artisan iris-claw lenses for the correction of aphakia in children following lensectomy for ectopia lentis

Artisan iris-claw lenses for the correction of aphakia in children following lensectomy for ectopia lentis

Gene-Set Enrichment Analysis of Differentially Expressed Genes in the Transcriptome of the Human Corneal Endothelium in Association with Age Effecta

Soluble adenylyl cyclase in the eye

Contact Info

Product

Resources

About