Central corneal thickness and corneal volume changes in eyes with and without pseudoexfoliation after uneventful phacoemulsification

Asfuroğlu, Yonca; Kemer, Özlem Evren

doi:10.1007/s10792-017-0804-z

Cited by 9 publications

(5 citation statements)

References 28 publications

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“…In Lithuania, PEX prevalence was found to be 47.3% in 76–83-year-old age group, which is slightly higher than a population with similar characteristics in Iceland (40.6% of those who are 80 years old) [ 6 ]. PEX prevalence increased with age in all studies [ 9 , 12 , 13 , 23 , 26 – 29 ] and this is in agreement with our finding, as in our study PEX subjects were older than those without it (72.2 ± 8.1 years vs 68.6 ± 8.2 years, respectively). Similarly to our results, in Turkey the highest PEX rate was in the 80 years old patients (18.4%) with an increased odds ratio of 45.78 (p < 0.01) when compared to the 40–49 age-group [ 23 ].…”

Section: Discussionsupporting

confidence: 93%

Exploring association between pseudoexfoliation syndrome and ocular aging

et al. 2022

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Purpose Within a population-based follow-up study, to examine the 10-year incidence of pseudoexfoliation syndrome (PEX), possible risk factors for PEX and its association with ocular aging of the cornea, lens and retina. Methods The baseline examination was conducted in 2006 on a random sample of 1,033 adult participants from Kaunas city (Lithuania) population of whom 631 had ophthalmic examination data at attendance of the 10-year follow-up in 2016. Detailed examination of the anterior and posterior segment of the eye was carried out. After diagnostic mydriasis PEX was diagnosed by the presence of typical grayish-white exfoliation material on the anterior capsule surface of the lens. The participants were divided to PEX and non-PEX groups. Results PEX prevalence increased from 9.8 to 34.2% from baseline to 10-year follow-up. Nuclear cataract was common both in the PEX group (66.7%) and in those without PEX (72.2%), but this difference did not reach statistically significantly increased risk of developing cataract in those with PEX (OR 1.2; p = 0.61). Central corneal thickness (CCT) was thinner in the PEX group (529 ± 34 μm) and in the oldest group (525 ± 36 μm) (p < 0.001). Compared to baseline, corneal curvature (CC) became flatter in both groups (7.6 ± 0.27 vs 7.7 ± 0.26 mm; p < 0.001) during the follow-up, but the difference did not reach significance between groups. Corneal astigmatism was most commonly with-the-rule in both groups (37 (50.0%) vs 148 (68.5%); p > 0.05). Age, sex and PEX had no influence on age-related macular degeneration distribution. Conclusion The prevalence of PEX increased significantly with age in our population, with those with PEX having thinner and flatter corneae, but no difference in cataract and age-related macular degeneration characteristics.

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Section: Discussionsupporting

confidence: 93%

Exploring association between pseudoexfoliation syndrome and ocular aging

et al. 2022

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“…Parallel to these, in our study, we found an average increase of 13.1 μ m in the CCT at 1 minute, and we found that it returned to normal after 30 minutes. CCT and CV are used for corneal ectatic disease detection, before refractive surgery, and evaluation of the corneal status and corneal endothelial function [ 19 – 21 ]. Postoperative elevations of CCT and CV were observed in patients with long phacoemulsification, high power, and complicated cataract surgery, especially in patients with pseudoexfoliation syndrome, and the risk of corneal decompensation was high in these patients [ 22 – 24 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Proparacaine 0.375%-Sodium Fluorescein 0.25% Eye Drop Mixture and Fluorescein Strip on Anterior Segment Parameters

Doğan

Sabaner

Erol

2018

Journal of Ophthalmology

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Purpose To determine the effect of proparacaine 0.375%-sodium fluorescein 0.25% eye drop mixture and fluorescein strip on anterior segment parameters commonly used in routine ophthalmology practice. Methods 115 healthy volunteers without any systemic or ocular disease were divided into two groups. 57 volunteers were in the proparacaine 0.375%-sodium fluorescein 0.25% eye drop mixture group, and 58 volunteers were in the fluorescein strip group. Measurements (CCT (central corneal thickness), topographic pupil diameter, AD (aqueous depth), ACV (anterior chamber volume), ICA (iridocorneal angle), LLD (limbus-limbus distance), and CV (corneal volume)) were taken before and at 1, 5, 15, and 30 minutes after application. Results 59 (51.3%) participants were female, and 56 (48.7%) were male. The mean age of the drop application group was 26.88 ± 8.03, and the mean age of the strip application group was 26.33 ± 7.28. The mean CCT was 556 ± 32 μm before drop application and 569 ± 30 μm in the 1st minute, 560 ± 32 μm in the 5th minute, and 559 ± 31 μm in the 15th minute. The change was statistically significant (p < 0.001, p=0.005, and p=0.013, resp.). Before the strip application, mean CCT was 552 ± 36 μm, while it increased to 556 ± 36 μm at the 1st minute, and this change was statistically significant (p=0.002). The mean CV before dropping was 59.29 ± 3.53 mm3 and 60.62 ± 3.53 mm3 at the 1st minute and 59.66 ± 3.70 mm3 at the 5th minute, which was statistically significant (p < 0.001 and p=0.034). Mean topographic pupil diameters at the 1st, 5th, 15th, and 30th minute after application of drops and strips were not significantly changed compared to the preapplication values in the AD, ACV, ICA, and LLD measurements. Conclusions Proparacaine 0.375%-sodium fluorescein 0.25% eye drop mixture and fluorescein strip application lead to a temporary change in CCT and CV of the anterior segment parameters. Anterior segment measurements with the Scheimpflug camera have to be done before topical fluorescein application.

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“…On the contrary, Krysik found CCT thicker in PEX group [41]. Many authors report that there is no signi cant difference in CCT between PEX and no-PEX groups [7,37,38,[42][43][44][45].…”

Section: Discussionmentioning

confidence: 97%

Pseudoexfoliation Syndrome Association with Aging and Ocular Changes in Cornea, Lens, Retina

Rumelaitienė

Žaliūnienė

Špečkauskas

et al. 2021

Preprint

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Purpose: To examine the 10-year incidence of the pseudoexfoliation syndrome (PEX), possible risk factors of PEX, and its association with aging and ocular changes in cornea, lens, retina within a population-based follow-up study.Methods: The baseline examination was conducted in 2006 on a random sample of 1,033 adult participants from Kaunas city (Lithuania) population. Out of them 631 participants returned to the follow-up study in 2016. Ophthalmological examination included keratometry, central corneal pachymetry, after diagnostic mydriasis lens opacification was evaluated by LOCS III International classification, PEX was diagnosed by the presence of typical grayish-white exfoliation material on the anterior capsule surface of the lens.Results: During the 10 years follow-up, the prevalence of the PEX increased from 9.8% to 34.2%. Nuclear cataract was diagnosed the most both in the PEX-group and those without, however, there was no statistically significantly increased risk of developing cataract in those with PEX when compared to those without PEX (OR 1.2; p=0.61). Central corneal thickness (CCT) was thinner in PEX group (529±34μm) and in the eldest group (525±36μm) (p<0.001). Compared to baseline, corneal curvature (CC) became steeper both in the PEX and the no-PEX groups during the follow-up (p=0.013), but the difference didn’t reach significance between groups. The biggest part of corneal astigmatism was with-the-rule in no-PEX and PEX groups (37 vs 148; p>0.05). The age, sex and PEX had no influence to age related macular degeneration distribution.Conclusion: The prevalence of the PEX increased significantly with age. CCT was thinner in PEX group and in elder people. CC was flatter in PEX group.

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Central corneal thickness and corneal volume changes in eyes with and without pseudoexfoliation after uneventful phacoemulsification

Abstract: Eyes with and without PEX syndrome exhibit similar corneal features before and after phacoemulsification. A surgery in early stages of cataracts in PEX syndrome, not only provides a non-complicated surgery, but also leads to a less damaged cornea similar to eyes without PEX.

Cited by 9 publications

References 28 publications

Exploring association between pseudoexfoliation syndrome and ocular aging

Exploring association between pseudoexfoliation syndrome and ocular aging

Effect of Proparacaine 0.375%-Sodium Fluorescein 0.25% Eye Drop Mixture and Fluorescein Strip on Anterior Segment Parameters

Pseudoexfoliation Syndrome Association with Aging and Ocular Changes in Cornea, Lens, Retina

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