Central Corneal Thickness and its Associations With Ocular and Systemic Factors: The Singapore Malay Eye Study

Su, Daniel; Wong, Tien Yin; Foster, Paul J.; Tay, Wan-Ting; Saw, Seang‐Mei; Aung, Tin

doi:10.1016/j.ajo.2008.10.013

Cited by 87 publications

(88 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…4 In addition, Singapore Malay Eye Study reported CCT was 547.7 μm in 40s and 532.3 μm in 70-80 years, applying that CCT decreased with age by 5.1 μm per decade. 12 In aspect with refractive error, more myopia and steeper corneal curvature were correlated with a higher IOP measurement. 4 Therefore, these uncorrected factors could possibly influence on IOP distribution with age.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, our study enrolled only healthy screening subjects, therefore older participants who had hypertension, high cholesterol, and cardiovascular disease, which were highly associated with high IOP in previous literature, were selectively excluded. 8,11,12,21 In this study, IOP was not corrected for corneal thickness and refractive error. Generally, eyes with thinner mean central corneal thickness (CCT) was known to be associated with lower IOP measurement.…”

Section: Discussionmentioning

confidence: 99%

“…4 In addition, IOP was also associated with other medical problems including metabolic syndrome and chronic kidney disease in previous reports. 11,12 Previous reports about age and IOP mostly employed the cross-sectional population design. Analyzing changes in IOP by aging using longitudinal analysis is a more appropriate method.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Longitudinal analysis of age-related changes in intraocular pressure in South Korea

Baek

Kee

Suh

2015

Eye

View full text Add to dashboard Cite

Purpose To assess the changes in intraocular pressure (IOP) with age in South Korea Methods Subjects aged 20-79 who had been receiving health examinations at a university hospital were enrolled. They completed physical and ophthalmic examinations. Subjects with ocular disease that could possibly affect their IOP were excluded. The relationships between IOP and age, blood pressure, heart rate, body mass index, blood chemistry, and electrolyte were analyzed using a linear mixed model. Results Of the 33 712 subjects, 31 857 participants were enrolled. In a cross-sectional analysis, IOP also showed a negative correlation in all age groups (respectively, Po0.001). In particular, patients in their 60s~80s had a less steep decreasing slope of IOP with age than patients in their 20s~30s (correlation coefficient − 0.260 and − 0.168, respectively). In longitudinal analysis, negative trend was shown in the slope of tendency in total subjects. When analyzing the effect of gender on the relationship between age and IOP, females had a less steep decreasing slope of IOP with age than males by 0.05 mm Hg. With regard to systemic parameters, systolic blood pressure and heart rate were positively correlated with IOP (Po0.001). Conclusion IOP was significantly decreased with age, although the amount of change was small. In women and older age groups, IOP was less decreased than that of men and young age groups. In addition, IOP was positively associated with systolic blood pressure and heart rate.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Longitudinal analysis of age-related changes in intraocular pressure in South Korea

Baek

Kee

Suh

2015

Eye

View full text Add to dashboard Cite

show abstract

“…Hence, it can be concluded that there is a definite relationship between MS and elevated IOP. Multitude of studies reported that CCT was greater in individuals with diabetes and MS. 12,35 The reason for this association is unknown but is believed to be related to the dysfunction of the corneal endothelial physiology and increased corneal hydration.…”

mentioning

confidence: 99%

“…[10][11][12] Hence, this study intended to compare the CCT of the patients to determine its association between MS and IOP.…”

mentioning

confidence: 99%

Association between components of metabolic syndrome and elevated intraocular pressure

Krishnamoorthy

Kaliaperumal

et al. 2017

Int J Res Med Sci

View full text Add to dashboard Cite

Background: Glaucoma is a group of eye diseases which result in damage to the optic nerve and ultimately vision loss. Elevated intraocular pressure (IOP) remains as the one major known risk factor for both the development and progression of glaucoma. Metabolic syndrome (MS) have been found to relate to elevated IOP. The aim of the study is to examine the association between MS and IOP by comparing central corneal thicknesses (CCT).Methods: The study was carried out with 169 subjects consists of 94 were clinically diagnosed MS patients and 75 are healthy controls. Serum fasting glucose, triglyceride and HDL cholesterol levels were measured, and waist circumference, body mass index and blood pressure of all patients were recorded. Ophthalmological examinations, including IOP and CCT measurements were done on everyone.Results: Higher IOP was observed in subjects with MS than those without MS. There was significant difference in the CCT values between the groups with and without MS (p<0.05). Most of the MS components were associated with IOP and CCT (p<0.05).Conclusions: The study concludes that components of MS have strong association with IOP and CCT. The prevalence of MS is increasing rapidly in developing countries and the main cause for MS is sedentary lifestyle. Since there is relationship between MS and IOP, lifestyle intervention might have therapeutic potential to reduce IOP. Further studies are warranted to bring about the possible underlying relationship between components of MS and IOP.

show abstract

Effect of Corneal Arcus on Central Corneal Thickness, Intraocular Pressure, and Primary Open-angle Glaucoma

Wu¹

2010

Arch Ophthalmol

View full text Add to dashboard Cite

To examine the association of corneal arcus with central corneal thickness (CCT), intraocular pressure (IOP), and the prevalence of primary open-angle glaucoma. Methods: This was a population-based cross-sectional study of Malay participants aged 40 to 80 years living in Singapore. Participants underwent a standardized interview and systemic and ocular examinations, including CCT, IOP, and corneal curvature radius measurements. Corneal arcus, assessed using a slitlamp, was defined as graywhite or yellow opacity located near the periphery of the cornea but separated from the limbus by a clear zone. Results: Corneal arcus was found in right eyes among 1747 (57.9%) of 3015 participants. After adjusting for age, sex, and systemic factors, IOP was higher (15.87 vs 14.86 mm Hg, PϽ.001) and CCT was thinner (540.6 vs 543.4 µm, P=.03) in eyes with vs without corneal arcus. In multiple linear regression models, eyes with corneal arcus had on average 1.14 mm Hg higher IOP than eyes without corneal arcus. In the presence of corneal arcus, the linear correlations of CCT ϫ IOP and of corneal curvature radiusϫIOP were altered. The prevalence of ocular hypertension, but not primary open-angle glaucoma, was significantly higher among participants with corneal arcus than among participants without corneal arcus (P=.02). Conclusions: Corneal arcus was associated with higher IOP and lower CCT independent of age, sex, and systemic and ocular factors. Further research is required to investigate the clinical implications of these findings for IOP assessment in eyes with corneal arcus.

show abstract

Central Corneal Thickness and its Associations With Ocular and Systemic Factors: The Singapore Malay Eye Study

Cited by 87 publications

References 41 publications

Longitudinal analysis of age-related changes in intraocular pressure in South Korea

Longitudinal analysis of age-related changes in intraocular pressure in South Korea

Association between components of metabolic syndrome and elevated intraocular pressure

Effect of Corneal Arcus on Central Corneal Thickness, Intraocular Pressure, and Primary Open-angle Glaucoma

Contact Info

Product

Resources

About