Central corneal thickness in Iranian congenital glaucoma patients

Abstract

Purpose:To compare central corneal thickness (CCT) in subjects with controlled primary congenital glaucoma (PCG) and nonglaucomatous subjects and to investigate the correlation between CCT and intraocular pressure (IOP) in the study population.Materials and Methods:Twenty-three consecutive PCG cases with controlled IOP and no clinical evidence of corneal edema comprised the Study Group. There was an interval of at least 2 months between last intraocular surgery and inclusion in the study. Twenty-one subjects with strabismus or lacrimal drainage insufficiency who did not have glaucoma or any history of intraocular surgery or ocular trauma comprised the control group. The Control Group was age and sex-matched. Data from ultrasonic pachymetry and applanation tonometry were analyzed for differences between groups. Correlation of the study parameters was investigated. A P-value less than 0.05 was statistically significant.Results:Data from both eyes of subjects in the Study Group and Control Group were included in the original analysis. Mean CCT was statistically significantly higher in the Study Group compared to the Control Group (589.42 ± 53.44 μm vs. 556.14 ± 30.51 μm, respectively; P=0.001). There was a significant correlation between CCT and IOP (r=0.63; P<0.0001). Similar statistically significant outcomes were observed when only one eye per subject was used in a reanalysis of the data for the Study and Control Groups.Conclusion:Patients with PCG who had controlled IOP have statistically significantly thicker corneas than nonglaucomatous age and sex-matched subjects The thicker cornea could significantly alter IOP measurement with applanation tonometry. Pachymetry should be considered an essential part of the evaluation for PCG.

Ultrasound biomicroscopy as a diagnostic tool in infants with primary congenital glaucoma

“…On the other hand, other studies reported significantly thicker CCT in patients with PCG 8,22,23. Corneal thickening in congenital glaucoma could be an inherent component of the pathophysiology and related to racial and genetic background.…”

“…Corneal thickening in congenital glaucoma could be an inherent component of the pathophysiology and related to racial and genetic background. Alternately, the thicker cornea could be due to the presence of subclinical corneal edema as a result of endothelial dysfunction and long-lasting IOP elevation 23. Oberacher-Velten et al22 concluded that even apparently clear corneas under high IOP in congenital glaucoma might have subclinical edema.…”

Corneal profile in primary congenital glaucoma

“…Daneshvar et al. () reported thicker corneas in patients with PCG and suggested the cause to be corneal oedema or endothelial dysfunction. Most other studies have reported significant corneal thinning in PCG as compared to control eyes (Henriques et al.…”

Features of measurement of intraocular pressure in children

“…Большинство авторов, отмечая это обстоятельство, вместе с тем сообщают, что еди-ное мнение по поводу динамики центральной тол-щины роговицы при врождённой глаукоме пока отсутствует [13,16,25,26,30,36,40,44,54,56,57]. Более подробно эти сведения рассмотре-ны ниже.…”

“…Так, H. Amini et al (2012) определили, что у детей с первичной врождённой глаукомой (при условии нормализации ВГД) определяется даже несколько более «толстая» роговица, чем у здоровых детей аналогичного возраста и пола (589,42 ± 53,44 и 556,14 ± 30,51 мкм соответ-ственно) [13]. Кроме того, K.W.…”