Central dexmedetomidine attenuates cardiac dysfunction in a rodent model of intracranial hypertension

Hall, Sean; Wang, Louie; Milne, Brian; Hong, Murray

doi:10.1007/bf03018493

Cited by 16 publications

(10 citation statements)

References 34 publications

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“…Hall et al studied on model where intracranial hypertension was created to rodents, they injected intracisternal dexmedetomidine and observed that the left ventricular function was well protected and they thought this result was due to prevention of increased catecholamine release by dexmedetomidine which results in decreased free oxygen radical formation in heart tissue. In this study also the MDA levels in the dexmedetomidine group was lower than that in the control group [33]. In a recent study where the effect of dexmedetomidine was searched to decrease I/R injury due to tourniquet application for upper limb surgery, the MDA values in the dexmedetomidine group was significantly lower in respect to control group during the reperfusion phase [34].…”

Section: Discussionsupporting

confidence: 47%

The Effect of Dexmedetomidine and Propofol on Oxidative Stress and Antioxidizing System Studied on Liver Ischemia-reperfusion Model on Rats

Urfalıoğlu¹,

Cantürk²,

Akçaboy³

et al. 2013

J Anesthe Clinic Res

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Surgical procedureAnesthesia was induced with Ketamine to rats, (Ketalar flk, Eczacıbaşı) with a dose of 90 mg/kg. Under sterile cover, laporatomy was performed via midline incision. Hepatoduodenal ligament was Materials and methods: 24 rats were randomly divided into four groups. Following anesthesia laparotomy was done and hepatoduodenal ligament was explorated. Tissue samples were taken for both biochemical (MDA, SOD, GPx) and histological study.Results: MDA level was hisghest in Group II and was significantly lower in Group III and Group IV. GPx level was lowest in Group II, the level of GPx was higher in Group III and Group IV with respect to Group II. SOD level was lowest in Group II and was highest in Group IV. SOD levels in Group II and Group III did not show statistical significance. In the histopathological study, in Group I the liver parenchyme and membrane integrity was protected; in Group II the hepatocyte cellular membrane integrity was distorted, microvesicule number increased and the liver sinusoids were shrunken; in Group III the hepatocyte membrane and nucleus was near normal and well protected; and in Group IV the cellular component structures were protected, hepatocyte cell membrane was protected in normal thickness. Discussion:The results show that dexmedetomidine and propofol decrease the level of MDA in similarly; the effect of dexmedetomidine on GPx level was slightly lower than propofol and its effect on SOD level was lower than propofol. As a result, we believe that either propofol or dexmedetomidine can be effective in protecting hepatocytes from I/R injury especially in log term procedures but the former drug having dominance in this protective role.

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Section: Discussionsupporting

confidence: 47%

The Effect of Dexmedetomidine and Propofol on Oxidative Stress and Antioxidizing System Studied on Liver Ischemia-reperfusion Model on Rats

Urfalıoğlu¹,

Cantürk²,

Akçaboy³

et al. 2013

J Anesthe Clinic Res

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“…Another possibility suggested is that by decreasing plasma catecholamines and tissue MDA in the heart, dexmedetomidine attenuates cardiac ischemia. 28 Dexmedetomidine is a lipophilic phenyl imidazole derivative with a higher affinity for ␣ 2 -adrenoceptors than that of the prototype drug clonidine. 29 Clonidine produces the membranotropic and membrano-stabilizing effects, which are associated with high lipophilic activity.…”

Section: Discussionmentioning

confidence: 99%

Dexmedetomidine Reduces the Ischemia-Reperfusion Injury Markers During Upper Extremity Surgery With Tourniquet

Yağmurdur

Özcan²,

Dokumaci³

et al. 2008

The Journal of Hand Surgery

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“…[22] have also shown that neonatal rats (7 days old) are more sensitive to dexmedetomidine than older pups (15-29 days old). Intracisternal administration of dexmedetomidine has prevented the rise of plasma norepinephrine, blocked the electrocardiographic abnormalities and preserved cardiac function in a rat model of intracranial hypertension [23]. Dexmedetomidine also exerts direct protective effect on left ventricular dysfunction caused by hypoxia-reoxygenation in rats [24] and decreases airway reactivity [25].…”

Section: Discussionmentioning

confidence: 99%

Effects of Subchronic versus Acute in utero Exposure to Dexmedetomidine on Foetal Developments in Rats

Tariq

Černý

Elfaki

et al. 2008

Basic Clin Pharma Tox

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Dexmedetomidine is a highly selective and specific α -2 adrenergic agonist with sedative, analgesic and sympathetic activities. This study was undertaken to investigate the effects of in utero exposure of dexmedetomidine on foetal development and postnatal behaviour in the offspring. Pregnant Sprague-Dawley rats were chronically treated with dexmedetomidine (0, 5, 10 and 20 µ g/kg, subcutaneously) daily from gestation day 7 to day 19. Another group of animals received only a single acute dose of dexmedetomidine (20 µ g/kg) on gestational day 19 to mimic a model for systemic analgesia during labour. Administration of dexmedetomidine did not affect the frequency of implantations. Chronic administration of 10 and 20 µ g/kg of dexmedetomidine significantly reduced the body weight and crown-rump length of pups, whereas a single acute dose (20 µ g/kg) did not affect these parameters. None of the pups exhibited any external malformations or skeletal abnormalities irrespective of treatment assigned. All the pups showed a normal postnatal weight gain during the developmental phase. No significant differences were observed among any of the groups with respect to behavioural performances of offspring in beam balance, grip strength and inclined plane tests as well as motor activity. In conclusion, acute exposure to dexmedetomidine at the anticipated delivery time does not exert any adverse effects on perinatal morphology of pups, their birth weight, crown-rump length, physical growth and postnatal behavioural performances. Since this study was conducted in rats, its clinical relevance in human beings remains to be unclear and warrants further studies.

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Central dexmedetomidine attenuates cardiac dysfunction in a rodent model of intracranial hypertension

Abstract: The results demonstrate that dexmedetomidine attenuates cardiac dysfunction associated with ICH. Our results provide evidence for the role of central sympathetic hyperactivity in the development of cardiac dysfunction associated with ICH.

Cited by 16 publications

References 34 publications

The Effect of Dexmedetomidine and Propofol on Oxidative Stress and Antioxidizing System Studied on Liver Ischemia-reperfusion Model on Rats

The Effect of Dexmedetomidine and Propofol on Oxidative Stress and Antioxidizing System Studied on Liver Ischemia-reperfusion Model on Rats

Dexmedetomidine Reduces the Ischemia-Reperfusion Injury Markers During Upper Extremity Surgery With Tourniquet

Effects of Subchronic versus Acute in utero Exposure to Dexmedetomidine on Foetal Developments in Rats

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