Central Diabetes Insipidus in a Cat with Central Nervous System B Cell Lymphoma

Abstract

A 6-year-old male neutered cat presented with blindness, lethargy, polydipsia, hyposthenuria and severe hypernatraemia. Central diabetes insipidus was demonstrated by means of a low measured anti-diuretic hormone (ADH) concentration in the face of hypernatraemia, and clinical response to supplementation with desmopressin. Magnetic resonance imaging of the brain showed a discrete mass in the region of the hypothalamus. The cat was euthanased and post-mortem histological examination demonstrated B cell lymphoma involving the brain, optic nerves, urinary bladder wall and diaphragm. To the authors' knowledge, this case report is the first to describe central diabetes insipidus caused by central nervous system lymphoma in the cat.

PlasmaACTHPrecursors in Cats with Pituitary‐Dependent Hyperadrenocorticism

“…Plasma ACTH concentration was measured with an immunoluminometric assay (ILMA) previously used in cats . The reference interval used was 8–93 pg/mL.…”

“…Plasma ACTH concentration was measured with an immunoluminometric assay (ILMA) f previously used in cats. 7,36 The reference interval used was 8-93 pg/mL. We determined the POMC/pro-ACTH concentrations of plasma samples from cats with the OCTEIA POMC kit, g validated according to current procedures for bioanalytical analysis.…”

Lower Urinary Tract Cancer

“…[68][69][70][71][72][73][74] Like dogs, the most common lower urinary tract tumor is TCC. [75][76][77][78][79][80] Others include various sarcomas, 75,81,82 leiomyomas, 83 lipomas, 84 and lymphoma, either as part of multicentric disease or localized to the urinary bladder. 75,77,78,85,86 Patient Evaluation Overview Signalment Older cats (median age, 10-15 years) are predisposed to urinary bladder tumors in general, but lymphoma may be seen in cats as young as 1 year of age.…”

“…[75][76][77][78][79][80] Others include various sarcomas, 75,81,82 leiomyomas, 83 lipomas, 84 and lymphoma, either as part of multicentric disease or localized to the urinary bladder. 75,77,78,85,86 Patient Evaluation Overview Signalment Older cats (median age, 10-15 years) are predisposed to urinary bladder tumors in general, but lymphoma may be seen in cats as young as 1 year of age. 75,76,[78][79][80] A male predisposition has been seen in some studies but not others, 76,78,80 and there is no known breed predilection.…”

“…Although metastasis is not common (0%-27%) at diagnosis in TCC, 76,80 widespread disease can occur (lymph nodes and lungs are common sites), and complete abdominal ultrasound and thoracic radiographs should be performed. [76][77][78]86,90 Imaging Reported abnormalities on abdominal radiographs (plain or contrast studies) include bladder distension, thickened or calcified bladder wall, and presence of a mass. 78 Ultrasound has mostly superseded radiography for detection of lower urinary tract neoplasia.…”