2002
DOI: 10.1016/s0014-2999(02)01502-9
|View full text |Cite
|
Sign up to set email alerts
|

Central effects of 1,4-butanediol are mediated by GABAB receptors via its conversion into γ-hydroxybutyric acid

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

6
41
0
2

Year Published

2003
2003
2014
2014

Publication Types

Select...
6
1
1

Relationship

1
7

Authors

Journals

citations
Cited by 62 publications
(49 citation statements)
references
References 30 publications
6
41
0
2
Order By: Relevance
“…These results are in close agreement with previous data demonstrating the lack of any effect, or even a potentiation, of pretreatment with NCS-382 on hypomotility, sedation / hypnosis, and lethality induced by GHB and/ or 1,4-BD (7,18,19,27). Taken together, these results suggest that the specific-GHB binding site contributes minimally to the above effects of GHB and its precursors.…”
Section: Discussionsupporting
confidence: 93%
See 2 more Smart Citations
“…These results are in close agreement with previous data demonstrating the lack of any effect, or even a potentiation, of pretreatment with NCS-382 on hypomotility, sedation / hypnosis, and lethality induced by GHB and/ or 1,4-BD (7,18,19,27). Taken together, these results suggest that the specific-GHB binding site contributes minimally to the above effects of GHB and its precursors.…”
Section: Discussionsupporting
confidence: 93%
“…These doses of SCH 50911 were chosen on the basis of previous experiments demonstrating that they completely protected against lethality induced by GHB (19) and 1,4-BD (8). At 1,2,3,4,5,6,7,8,9,12,18, and 24 h after GBL administration, the presence of vital signs (such as respiratory movements) was monitored.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…The rank-order potency was as follows: diazepam ϭ baclofen Ͼ GBL Ͼ 1,4-BDL ϭ GHB. The finding that the GHB precursor GBL (and to a lesser extent 1,4-BDL) is more potent than GHB in suppressing simple schedulecontrolled behavior is in agreement with other studies that have reported greater potency of GHB precursors than GHB when sleep time (Carai et al, 2002b) and discriminative stimulus effects (Carter et al, 2003) were measured. Greater potency of GHB precursors compared with GHB may be due to more complete penetration of the brain by the precursors; GBL and 1,4-BDL are less polar than GHB, do not bind to GHB or GABA receptors (Carter et al, 2002), and are stoichiometrically converted to GHB in vivo.…”
Section: Discussionsupporting
confidence: 91%
“…Recent publications have demonstrated that the cardiovascular and behavioral responses elicited by BDL require its metabolism to GHB via alcohol and aldehyde dehydrogenase (9,16). Like GHB, the dose-response relationships for BDL and MAP and heart rate are nearly identical following parenteral administration of BDL (0.18 to 1.0 g/kg, i.p.…”
Section: Discussionmentioning
confidence: 99%