Central effects of cholinesterase inhibitors in Alzheimer’s disease: insights from advanced neuroimaging

Venneri, Annalena; Shanks, Michael F.

doi:10.2217/iim.13.51

Cited by 1 publication

(2 citation statements)

References 87 publications

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“…Although the study of CS in the presence of a diagnosis of AD is usually driven by an interest in the clinical efficacy of the treatment rather than in the understanding of the mechanisms that lead to positive changes, it is important to estimate at least the extent to which CS contributes to any improvements when CS is only one component of a multimodal treatment. The use of cholinergic treatment for AD is based on specific hypotheses and is associated to an extensive literature that has described the specific changes at a neural level in patients with AD [12][13][14]. In contrast, the mechanisms of CS are not fully known.…”

Section: Part 1: Cognitive Stimulation In the Presence Of A Diagnosismentioning

confidence: 99%

“…that activates in the absence of explicit mental tasks. Based on this, measures of neuroimaging might become an important marker of treatment effects of CS, similarly to the way they can track down the impact of pharmacological treatment [12][13][14]. Our objective was, therefore, to summarise the main experimental findings in this research field, with particular focus on the timeline of AD and on its neural involvement.…”

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confidence: 99%

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Cognitive stimulation of the default-mode network modulates functional connectivity in healthy aging

Marco

Meneghello

Duzzi

et al. 2016

Brain Research Bulletin

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A cognitive-stimulation tool was created to regulate functional connectivity within the brain Default-Mode Network (DMN). Computerized exercises were designed based on the hypothesis that repeated task-dependent coactivation of multiple DMN regions would translate into regulation of resting-state network connectivity. Forty seniors (mean age: 65.90 years; SD: 8.53) were recruited and assigned either to an experimental group (n=21) who received one month of intensive cognitive stimulation, or to a control group (n=19) who maintained a regime of daily-life activities explicitly focused on social interactions. An MRI protocol and a battery of neuropsychological tests were administered at baseline and at the end of the study. Changes in the DMN (measured via functional connectivity of posterior-cingulate seeds), in brain volumes, and in cognitive performance were measured with mixed models assessing group-by-timepoint interactions. Moreover, regression models were run to test gray-matter correlates of the various stimulation tasks. Significant associations were found between task performance and gray-matter volume of multiple DMN core regions. Training-dependent up-regulation of functional connectivity was found in the posterior DMN component. This interaction was driven by a pattern of increased connectivity in the training group, while little or no up-regulation was seen in the control group. Minimal changes in brain volumes were found, but there was no change in cognitive performance. The training-dependent regulation of functional connectivity within the posterior DMN component suggests that this stimulation program might exert a beneficial impact in the prevention and treatment of early AD neurodegeneration, in which this neurofunctional pathway is progressively affected by the disease.

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Section: Part 1: Cognitive Stimulation In the Presence Of A Diagnosismentioning

confidence: 99%

mentioning

confidence: 99%

Cognitive stimulation of the default-mode network modulates functional connectivity in healthy aging

Marco

Meneghello

Duzzi

et al. 2016

Brain Research Bulletin

Self Cite

View full text Add to dashboard Cite

show abstract

Central effects of cholinesterase inhibitors in Alzheimer’s disease: insights from advanced neuroimaging

Cited by 1 publication

References 87 publications

Cognitive stimulation of the default-mode network modulates functional connectivity in healthy aging

Cognitive stimulation of the default-mode network modulates functional connectivity in healthy aging

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