Central giant cell granuloma of the head &amp; neck: A case report and systematic review

Richardson, Jarrett W.; Stanbouly, Dani; Litman, Eric; Lee, Kevin C.; Philipone, Elizabeth

doi:10.1016/j.jormas.2021.08.004

Cited by 12 publications

(12 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has been a while since clinical behavior and treatment prognosis of different lesions are determined according to their histological findings. Several studies have shown that CGCG's clinical behavior and its histological features are associated too(Melo-Muniz et al, 2020).In the present study, incidence rate of CGCG lesions was not different between two genders Richardson et al (2022). study's data is similar to the current study findings.…”

supporting

confidence: 89%

See 1 more Smart Citation

Evaluation of the relationship between the expression of AgNOR and Ki67 with the recurrence rate in central granulomatous giant cell lesions: A case‐control

Dareh,

Andisheh‐Tadbir,

Aghakouchakzadeh

2024

Clinical & Exp Dental Res

View full text Add to dashboard Cite

ObjectivesGiant cell granuloma is a local nonneoplastic lesion that is divided into two categories, based on its site of occurrence: Central and peripheral giant cell granuloma. Central giant cell granuloma is an intraosseous lesion that has a tendency to recure even in surgically treated cases. Several studies have proven that there is an association between different lesions clinical behavior and their histological features. The aim of this study was to evaluate the expression of AgNOR and Ki67 in lesions with and without recurrency.Material and MethodsFiles and records of 35 patients who had been histologically diagnosed with central giant cell granuloma were investigated. Histological features were studied after performing AgNOR staining and Ki67 marker. The data were analyzed by chi‐square, Fisher, and T‐test.ResultsAcquired data indicated that the count of AgNOR staining and Ki67 marker was significantly higher in lesions with recurrency than the lesions with no recurrency. The same results were attained from Ki67 intensity.ConclusionThe current study indicated that AgNOR staining and Ki67 marker have prognostic value in predicting recurrency of central giant cell granuloma lesions.

show abstract

supporting

confidence: 89%

“…CGCG's tendency for recurrence is still a challenge (Richardson et al, 2022). Recurrence rate of CGCG can be different in aggressive and nonaggressive types and in lesions with more aggressive behavior, it is seen to be up to 70% (De Cidrac et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the relationship between the expression of AgNOR and Ki67 with the recurrence rate in central granulomatous giant cell lesions: A case‐control

Dareh,

Andisheh‐Tadbir,

Aghakouchakzadeh

2024

Clinical & Exp Dental Res

View full text Add to dashboard Cite

show abstract

“…it was found that GCGs are commonly occur in the second or third decades of life [ 19 ]. In the systematic review by Jordan Richardson et.al, out of 55 cases of GCG, the mean age of the patients was under 30 years [ 20 ]. These results are consistent with the findings in our study with an age of 11 years old boy.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have states that they are three times more likely to be afflicted than males [ 19 , 21 ]. Jordan Richardson et.al reported an even sex distribution in a study of 55 cases of CGCG [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Central giant cell granuloma in the posterior region of mandible mimicking a fibro-osseous lesion and hemangioma: a case report

Tabatabaei,

Paknahad,

Garmabi

et al. 2024

J Med Case Reports

View full text Add to dashboard Cite

Background A central giant cell granuloma (CGCG) is a benign, proliferative, intraosseous, and non-odontogenic lesion occurring primarily in children and young adults. On the histological level, it is characterized by numerous multinucleated giant cells scattered randomly throughout a sea of spindle-shaped mesenchymal stromal cells which are dispersed throughout the fibrovascular connective tissue stroma containing areas of haemorrhage. When it comes to radiographic features, CGCG can have an array of variations, ranging from well-defined expansile lesions to ill-defined and destructive lesions, with or without expansion. Case presentation This case report reviews an 11-year-old Caucasian patient with a chief complaint of slow-growing swelling involving the right posterior mandibular region. The cone beam computed tomography (CBCT) revealed an ill-defined mixed lesion mimicking both fibro-osseous lesion and hemangioma. However, microscopic examination revealed multinucleated giant cells in a fibrous stroma suggestive of central giant cell granuloma. Conclusion Our intent in reporting this case is to highlight the importance of thorough clinical, radiographical and histopathological examination for accurate diagnosis and therapeutic interventions as well as to emphasize the importance of taking different possibilities into consideration when examining bony swellings in the head and neck region.

show abstract

“…Another pharmacological treatment method for non-aggressive forms of CGCG recommended by some authors include the use of calcitonin intranasally or by subcutaneous injection [ 26 , 27 , 34 , 35 , 36 ]. The function of calcitonin is to inhibit the activity of osteoclasts and thus limit the destruction of bone tissue.…”

Section: Introductionmentioning

confidence: 99%

Bony Canal Method of Dexamethasone Injections in Aggressive Form of Central Giant Cell Granuloma—Case Series

et al. 2023

View full text Add to dashboard Cite

Central Giant Cell Granuloma constitutes approximately 7% of benign tumors of the jaws. The aggressive form of CGCG clinically behaves like a classic semi-malignant neoplasm. In the literature, the suggested method of treatment of aggressive forms of CGCG is curettage or resection with the margin of 0.5 cm. Surgical treatment, especially in the developmental age, entails disturbances in the growth and differentiation of tissues and deforms and disturbs the functioning of the stomatognathic system. Alternative treatment methods of the CGCG presented in this article lead to the patient avoiding a mutilating procedure and improve their quality of life. The aim was to present alternative method of treatment of aggressive forms of Central Giant Cell Lesion of the jaws—injections of dexamethasone into the tumor mass through drilled bony canals. Here, we present the three cases of aggressive forms of CGCG of jaws treated with dexamethasone injections into the tumor mass. Two cases resulted in regression of the tumor, which was confirmed in histologic evaluation after remodeling surgery. Those two patients were uneventful and showed no signs of tumor recurrence at 8 and 9 years of thorough follow-up, respectively. The third patient was qualified for the mandible resection due to the enlargement of the lesion and destruction of the cortical bone. According to our observations, if the proper patient discipline, and thorough, careful clinical and radiological examinations are provided, the dexamethasone injections could be a recommended method of treatment of intraosseous giant cell granuloma. The indication is restricted to the cases with preserved bony borders despite deformation. Additionally, leaving vital teeth in the lesion is also possible.

show abstract

Central giant cell granuloma of the head & neck: A case report and systematic review

Cited by 12 publications

References 41 publications

Evaluation of the relationship between the expression of AgNOR and Ki67 with the recurrence rate in central granulomatous giant cell lesions: A case‐control

Evaluation of the relationship between the expression of AgNOR and Ki67 with the recurrence rate in central granulomatous giant cell lesions: A case‐control

Central giant cell granuloma in the posterior region of mandible mimicking a fibro-osseous lesion and hemangioma: a case report

Bony Canal Method of Dexamethasone Injections in Aggressive Form of Central Giant Cell Granuloma—Case Series

Contact Info

Product

Resources

About