Central giant cell granuloma of posterior mandible: Report of a case

Abstract

Central giant cell granuloma (CGCG) is a benign intraosseous lesion of the jaws. The lesion is considered to be a reactive phenomenon, a developmental anomaly, or a benign neoplasm. The clinical behavior of the lesion varies from an asymptomatic osteolytic lesion that grows slowly without expansion (non-aggressive), to an aggressive, painful process. Radiographically, the lesions appear as unilocular or multilocular radiolucencies with well-delineated borders. The occurrence of CGCG in the posterior mandible is a rare incidence. The present case is that of a 28-year-old female patient with a complaint of slow growing posterior mandibular swelling. The rarity of CGCG in the mandibular body-ramus area creates a diagnostic challenge as ameloblastoma, aneurysmal bone cyst, and odontogenic myxoma present commonly in the posterior mandibular region. Diagnosis is critical as a conservative line of management can be followed in case of CGCG as compared to radical treatment required in other lesions. This report describes the unusual presentation, the differential diagnosis, radiographic features, and management of this lesion.

Management of central giant cell granuloma: A case series

“…2 The incidence of CGCG in the general population is estimated to be 0.0001%.Giant cell granulomas may be encountered in patients ranging from 2 to 80 years of age, 60% of cases occurring before the age of 30. 3 Giant cell granuloma is often confused with giant cell tumour. However, a giant cell tumour can be distinguished based on fact that it occurs commonly between the ages of 25 and 40yrs, usually involving the long bones and is more aggressive in nature, with frequent recurrence after curettage.…”