Central giant cell granuloma of the jaws: A clinical, radiologic, and histopathologic study of 26 cases

Kruse‐Lösler, Birgit; Diallo, Raihanatou; Gaertner, Christoph; Mischke, K L; Joos, Ulrich; Kleinheinz, Johannes

doi:10.1016/j.tripleo.2005.02.060

Cited by 178 publications

(216 citation statements)

References 40 publications

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“…In the present study, PGCGs appeared more common in males, which is in contrast to the proved thesis that de-scribes predilection for female patients 3,9,11,[14][15][16] .Murat et al's also reported male predilection (56%) which was slightly higher than our results 17 . A mandible predominance (58.7%) was identified in our series, and is in agreement with other studies 4,9,14,17 . Similar to our results, previous studies 4,9,14,18 ,have been stated that molar and premolarareas of mandible were more often affected by CGCGs than the anterior parts.…”

Section: Resultscontrasting

confidence: 99%

“…The majority of studies agree that there is a female predominance for CGCG lesions 3,9,11,14,15 which is in agreement with our results. In the present study, PGCGs appeared more common in males, which is in contrast to the proved thesis that de-scribes predilection for female patients 3,9,11,[14][15][16] .Murat et al's also reported male predilection (56%) which was slightly higher than our results 17 .…”

Section: Resultssupporting

confidence: 92%

“…A total 1019 cases were evaluated, andepidemiologic findings were compared with previous studies. It is important to mention that we evaluated 1019 lesions in a 38-year period,whereas small number of cases consid ered in previous series 1,6,9,[11][12][13] . CGCGs occur more often in patients younger than 30 years of age 9,14,15 .In our study, a peak of occurrence was in the second decade of life, corresponding to the findings of other authors 11 .Although it has been shown that PGCGs occur more frequent in the fifth and sixth decades 3 the first decade was the most frequent age in the current study.In some studies patients were aged between four and seven decades, whereas most of our patients with PGCG were under 40 years old 1 .…”

Section: Resultsmentioning

confidence: 99%

“…It is more common in the mandible 3,6 . CGCG and PGCG are virtually identical histologically, beingcharacterized by the presence of osteoclast-like giant cells scattered in a cellular fibrovascularstroma.However, despitetheir similarity, distinct clinical behavior is observed for these lesions.CGCGs are benign aggressivedestructive osteolytic lesionwith rapid growth,pain, root resorptionand tendency to recur after excision, whereas low recurrence rate and rare bone or tooth resorption are seen in PGCGs [7][8][9] . There is considerable variation in the clinical behavior of CGCG.…”

Section: Introductionmentioning

confidence: 99%

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A 38-year demographic study of central and peripheral giant cell granulomas of the jaws

Saghafi

Zare-Mahmoodabadi

Ghazi

et al. 2016

Bangladesh J Med Sci

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Abstract:Objective: The purpose of this study was to retrospectively analyze the demographic characteristics of patients with central giant cell granulomas (CGCGs) and peripheral giant cell granulomas (PGCGs) in Iranian population. Methods: The data were obtained from records of 1019 patients with CGCG and PGCG of the jaws referred to our department between 1972 and 2010. This 38-year retrospective study was based on existing data. Information regarding age distribution, gender, location of the lesion and clinical signs and symptoms was documented. Results: A total of 1019 patients were affected GCGLs including 435 CGCGs and 584 PGCGs during the study. The mean age was 28.91 ± 18.16. PGCGs and CGCGs had a peak of occurrence in the first and second decade of life respectively. A female predominance was shown in CGCG cases (57.70%), whereas PGCGs were more frequent in males (50.85%). Five hundred and ninety-eight cases of all giant cell lesions (58.7 %) occurred in the mandible. Posterior mandible was the most frequent site for both CGCG and PGCG cases. The second most common site for PGCG was posterior maxilla (21%), whereas anterior mandible was involved in CGCG (19.45%). The majority of patients were asymptomatic. Conclusions: In contrast to most of previous studies PGCGs occur more common in the first decade and also more frequently in male patients. Although the CGCGs share some histopathologic similarities with PGCGs, differences in demographic features may be observed in different populations which may help in the diagnosis and management of these lesions.

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Section: Resultscontrasting

confidence: 99%

Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A 38-year demographic study of central and peripheral giant cell granulomas of the jaws

Saghafi

Zare-Mahmoodabadi

Ghazi

et al. 2016

Bangladesh J Med Sci

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“…Cerrahi yöntem küretajdan rezeksiyona çeşitlilik gösterir. SDHG kalsitoninin sistemik olarak günlük uygulanması [8][9][10][11] , kortikosteroidlerin lezyon içine enjeksiyonu [12][13][14] , radyasyon 15 ve subkütanöz interferon enjeksiyonu 16 gibi konservatif metotlarla da tedavi edilebilir.…”

Section: Introductionunclassified

Santral Dev Hücreli̇ Granülomanin İli̇ak Greft Ve Hareketli̇ Yer Tutucu Aparey İle Rehabi̇li̇tasyonu: Olgu Sunumu

Damlar¹,

Altan²,

Yanık³

et al. 2015

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

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ÖZETAmaç: Santral dev hücreli granüloma sıklıkla mandibula ve maksillada lokalize olan, non-odontojenik patolojik bir lezyondur. Etiyolojisi tam olarak bilinmemektedir. Lezyonun cerrahi olarak uzaklaştırılması en çok uygulanan tedavi yöntemidir. Amacımız bu vakada santral dev hücreli granülomanın iliak greft ve hareketli yer tutucu aparey kullanılarak rehabilitasyonunu rapor etmektir. Vaka raporu: 10 yaşındaki erkek hasta kliniğimize mandibula anterior sol bölgede şişlik şikayetiyle başvurdu. Alınan anamnezde, şikayetin olduğu bölgeye yaklaşık 1 yıl önce cerrahi bir müdahale yapıldığı, fakat şişliğin altı ay önce tekrar oluştuğu öğrenildi. Genel anestezi altında lezyon çıkartıldı. Mandibular sol santral, lateral, kanin ve birinci premolar dişler çekildi. Mandibulada oluşan defekt iliak greftle onarıldı. Çıkarılan kitlenin histopatolojik incelemesi yapıldı ve santral dev hücreli granülom tanısı konuldu. Operasyon sonrası yapılan 12 aylık takipte herhangi bir problemle karşılaşılmadı. Daha sonra hastaya hareketli yer tutucu bir aparey yapıldı. Sonuç: Literatürde santral dev hücreli granülom gibi agresif lezyonların %72 rekürens oranı olduğu görül-mektedir. Rekürens gösteren vakalarda kortikostreoid enjeksiyonu, sistemik kalsitonin uygulaması gibi konservatif yöntemlerin başarısı kesin değildir. Cerrahi tedavi çene kemiklerinde major defektlere neden olabilir ve fasiyal konturu bozabilir. Böyle bir durumda defektin iliak greftle tamiri estetik problemleri çözecektir ve protezle rehabilitasyon imkanı sunacaktır. Anahtar kelimeler: santral dev hücreli granüloma, iliak greft, hareketli yer tutucu ABSTRACT Purpose: Central giant cell granuloma is a nonodontogenic pathological lesion that usually located in the mandible and maxilla. The aetiology of giant cell granuloma is undefined. Surgical removal is the most commonly applied therapy. Our aim was to report rehabilitation of central giant cell granuloma with iliac graft and removable space maintainer. Case Report: A 10-years-old child was referred to our clinic complaining of swelling in the mandibular anterior region. The parents of the patient were reported that a surgical operation was done in mandibular anterior region of the patient one year ago. They also reported that this lesion was recurred six months after first surgery. The recurred lesion was removed under general anesthesia, mandibular left central, lateral, canine and first premolar teeth were extracted. Iliac crest graft was harvested and fixed to the mandible. The histopathology report confirms the diagnosis of a central giant cell granuloma. The patient's postoperative 12 months follow-up exam was uneventful. The patient was referred for removable space maintainer. Conclusion: Aggressive lesions such as central giant cell granuloma observed 72% recurrence rate to the literature. Conservative methods such as corticosteroid injection, systemic calcitonin's success isn't definite on the recurred lesion. The surgical treatment may cause major defects in jaw bones and changes the facial contours, the repai...

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Interventions for central giant cell granuloma (CGCG) of the jaws

Suárez‐Roa

Revéiz

Rivera

et al. 2009

Cochrane Database of Systematic Reviews

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Central giant cell granuloma of the jaws: A clinical, radiologic, and histopathologic study of 26 cases

Cited by 178 publications

References 40 publications

A 38-year demographic study of central and peripheral giant cell granulomas of the jaws

A 38-year demographic study of central and peripheral giant cell granulomas of the jaws

Santral Dev Hücreli̇ Granülomanin İli̇ak Greft Ve Hareketli̇ Yer Tutucu Aparey İle Rehabi̇li̇tasyonu: Olgu Sunumu

Interventions for central giant cell granuloma (CGCG) of the jaws

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