Central giant cell granuloma of the jaw: a review of the literature with emphasis on therapy options

Lange, Jan de; Akker, Hans P. van den; Berg, Henk van den

doi:10.1016/j.tripleo.2007.04.003

Cited by 273 publications

(336 citation statements)

References 101 publications

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“…In addition, the patient was treated with intralesional injections of corticosteroids [2]. This was supported by immunoreactivity of the lesional cells (both mononuclear and multinuclear giant) for corticosteroid receptors [7].…”

Section: Diagnosis and Discussionmentioning

confidence: 86%

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Clinico-Pathologic Conference AAOMP/IAOP 2008: Case 3

Vered

Bello

Salo

et al. 2008

Head and Neck Pathol

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Section: Diagnosis and Discussionmentioning

confidence: 86%

“…Cherubism is classically manifested as bi-lateral lesions in the posterior jawbones [2]. This long-time known observation has been recently explained on the basis of a spatio-temporal association between cherubism and the failure of development of the second and third permanent mandibular molars [3].…”

Section: Diagnosis and Discussionmentioning

confidence: 99%

Clinico-Pathologic Conference AAOMP/IAOP 2008: Case 3

Vered

Bello

Salo

et al. 2008

Head and Neck Pathol

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“…The interpretation of CBCT images must be carefully performed, always considering lesion location, size and development and relation to the adjacent structures as well as enlargement or disruption of the cortical bone (1)(2)(3)(4). With the introduction of CBCT, bone lesions have been more effectively assessed in comparison with conventional radiography, which does not provide details of the lesion and also produces superimposition of images (5)(6)(7)(8)(9)(10)(11). Nevertheless, the use of CBCT is still in discussion, since the radiation dose is higher than for the conventional radiographs.…”

Section: Introductionmentioning

confidence: 99%

Clinical and imagiological findings of central giant cell lesion and cherubism

Pinheiro

Júnior

et al. 2013

Braz. Dent. J.

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Cone beam computed tomography (CBCT) is the best examination for bone lesions of the maxilla, allowing the dentist to evaluate precisely the behavior and components of the lesion and their relationship to the surrounding structures. Central giant cell lesion and cherubism are histologically very similar lesions. Therefore clinical and radiological examinations are fundamentally important for the diagnosis. The aim of this paper is to report two cases diagnosed as central giant cell lesions and cherubism using CBCT. This imaging modality was very important for the diagnosis of the lesions presented in the current study. It also allowed observing precisely the limits of the lesions, the components, the behavior and the exact relationship to adjacent structures.

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“…The giant cells are usually clustered in areas of hemorrhage and hemosiderin deposition, while trabeculae of woven bone are seen in the periphery or in fibrous septae traversing the stroma. Central giant cell lesions can be seen in hyperparathyroidism (''brown tumors''), cherubism, Noonan syndrome and neurofibromatosis type 1 [6]. In the last two, this association may be coincidental.…”

Section: Introductionmentioning

confidence: 99%