2014
DOI: 10.1016/j.brainres.2014.09.042
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Central inflammatory response to experimental stroke is inhibited by a neuroprotective dose of dietary soy

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Cited by 12 publications
(9 citation statements)
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“…Ovariectomised Sprague-Dawley mice were divided into two groups, one fed with a soy-free diet and another one with a diet containing high levels of soy PhyEs for 5 weeks. Soy intake was associated with a reduced inflammatory response in the cerebral cortex after transient middle cerebral artery occlusion (Shambayati et al, 2014). Among PhyEs, pterostilbene (PTER), a dimethylated analogue of resveratrol found in grapes and berries, exhibits a neuroprotective role in H 2 O 2 -treated SY5Y cells, mainly through ERα stimulation, which presumably involves a positive regulation of anti-apoptosis Bcl-2 expression and the activation of the MAPK/ERK and PI3K/AKT signaling pathways (Song et al, 2015).…”
Section: Natural Xenoestrogensmentioning
confidence: 99%
“…Ovariectomised Sprague-Dawley mice were divided into two groups, one fed with a soy-free diet and another one with a diet containing high levels of soy PhyEs for 5 weeks. Soy intake was associated with a reduced inflammatory response in the cerebral cortex after transient middle cerebral artery occlusion (Shambayati et al, 2014). Among PhyEs, pterostilbene (PTER), a dimethylated analogue of resveratrol found in grapes and berries, exhibits a neuroprotective role in H 2 O 2 -treated SY5Y cells, mainly through ERα stimulation, which presumably involves a positive regulation of anti-apoptosis Bcl-2 expression and the activation of the MAPK/ERK and PI3K/AKT signaling pathways (Song et al, 2015).…”
Section: Natural Xenoestrogensmentioning
confidence: 99%
“…In addition, coumestrol is a phytoestrogen compound which has potential benefits for either prevention or therapeutics use against cerebral ischemia in males (45). In another study, it has been demonstrated that Soy dietary may play a role in the brain injury (46). Soy prevents memory impairment and brain tissue oxidative damage caused by ischemia in OVX rats (47).…”
Section: Discussionmentioning
confidence: 99%
“…The neuroprotective effect of estrogen in TBI animals has been suggested in our previous studies [7][8][9], and our recent study demonstrated that a soy diet can be neuropreventive in TBI [21], and also the estrogenlike activity of soy isoflavones has been indicated [11,12]. Therefore in this research, the neuroprotective effect of genistein, as an isoflavone of soy, in diffuse and severe experimental TBI was assessed.…”
Section: Introductionmentioning
confidence: 88%
“…Soy phytoestrogens have been introduced as an alternative to hormone replacement therapy, due to the deleterious effects of estrogen [10]. Soy isoflavones, such as genistein and daidzein have phytoestrogen properties [11,12] and can act as an estrogen receptor modulator or act through a non-estrogen receptor pathway [13].…”
Section: Introductionmentioning
confidence: 99%