2019
DOI: 10.3389/fphys.2019.00491
|View full text |Cite
|
Sign up to set email alerts
|

Central Inhibition of Tumor Necrosis Factor Alpha Reduces Hypertension by Attenuating Oxidative Stress in the Rostral Ventrolateral Medulla in Renovascular Hypertensive Rats

Abstract: Inflammation in the central nervous system is being considered a key player linked to neurogenic hypertension. Using combined in vivo and in vitro approaches, we investigated the effects of central inhibition of TNF-α on blood pressure, sympathetic tone, baroreflex sensitivity, and oxidative stress in the rostral ventrolateral medulla (RVLM) of rats with 2-kidney-1-clip (2K1C) renovascular hypertension. Continuous infusion of pentoxifylline, a TNF-α inhibitor, into… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

1
16
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
6

Relationship

0
6

Authors

Journals

citations
Cited by 17 publications
(17 citation statements)
references
References 43 publications
1
16
0
Order By: Relevance
“…Indeed, upregulation of the brain ADAM17 was associated with elevated TNF-α implicating that attenuation of TNF-α-related mechanisms could be mediating part of the phenotype observed in mice lacking hypothalamic ADAM17. Numerous reports suggest elevation of TNF-α and activation of inflammatory cells (microglia) within certain brain regions triggers hypertensive responses [97][98][99]. Therefore, future studies are expected to clarify whether TNF-α plays a regulatory role in ACE2 activity and other RAS components.…”
Section: Advances On the Protective Arm Of The Brain Rasmentioning
confidence: 99%
“…Indeed, upregulation of the brain ADAM17 was associated with elevated TNF-α implicating that attenuation of TNF-α-related mechanisms could be mediating part of the phenotype observed in mice lacking hypothalamic ADAM17. Numerous reports suggest elevation of TNF-α and activation of inflammatory cells (microglia) within certain brain regions triggers hypertensive responses [97][98][99]. Therefore, future studies are expected to clarify whether TNF-α plays a regulatory role in ACE2 activity and other RAS components.…”
Section: Advances On the Protective Arm Of The Brain Rasmentioning
confidence: 99%
“…In addition, it has been recorded that oxidative stress in areas such as CVO, hypothalamus, and brainstem can trigger cardiovascular problems. 86 , 88 Hypertension caused by ANG-II elevates the level of ROS, but hypertension induced by norepinephrine does not infer this parameter, indicating a characteristic effect of ANG-II. 86 , 88 …”
Section: Introductionmentioning
confidence: 99%
“… 86 , 88 Hypertension caused by ANG-II elevates the level of ROS, but hypertension induced by norepinephrine does not infer this parameter, indicating a characteristic effect of ANG-II. 86 , 88 …”
Section: Introductionmentioning
confidence: 99%
See 2 more Smart Citations